Metabolic profiling reveals therapeutic biomarkers of processed Aconitum Carmichaeli Debx in treating hydrocortisone induced Kidney-Yang deficiency syndrome rats

Tan, Yong; Liu, Xinru; Lü, Cheng; He, Xiaojuan; Li, Jian; Xiao, Cheng; Jiang, Miao; Yang, Jing; Zhou, Ke; Zhang, Zhongxiao; Zhang, Weidong; Lü, Aiping

doi:10.1016/j.jep.2014.02.011

Cited by 42 publications

(19 citation statements)

References 63 publications

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“…[15][16][17][18][19][20][21] It is a more effective approach by computational integration of different knowledge sources and unprecedent opportunities are provided by plentiful metabolomic data for drug target identification. 22 The core idea of metabolomics is to determine the metabolites of relatively low molecular weight, then to transform the data of metabolic profiles into useful information by pattern recognition tools, and to reveal the essence of diseases and assess therapeutic effects of drug. [23][24][25][26] In the current study, we performed a urinary metabolomics study on MG treatment for hyperlipidemia rats with multivariate statistics by ultraperformance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry (UPLC-ESI-QTOF-MS), and then identified the reliable biomarkers of hyperlipidemia.…”

Section: Introductionmentioning

confidence: 99%

A high-throughput metabolomic approach to explore the regulatory effect of mangiferin on metabolic network disturbances of hyperlipidemia rats

Cheng-yan

et al. 2015

Mol. BioSyst.

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This paper was designed to study metabolomic characters of the high-fat diet (HFD)-induced hyperlipidemia and the intervention effects of Mangiferin (MG). In this study, we aimed to investigate the intervention of MG on rats with hyperlipidemia induced by HFD and explore the possible mechanisms of hyperlipidemia. Urine metabolic profiles were analyzed using ultra-performance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry (UPLC-ESI-QTOF-MS) coupled with the principal component analysis (PCA) and partial least squares-discriminate analysis (PLS-DA) models, Heatmap and metabolism pathway analysis. PCA was applied to study the trajectory of the urinary metabolic phenotype of hyperlipidemia rat after administration of MG. The VIP-plot of orthogonal PLS-DA was used for discovering potential biomarkers to clarify the mechanism of MG. Biochemical analyses indicate that MG can alleviate the hyperlipidemia damage. Twenty significantly changed metabolites (potential biomarkers) were found to be reasonable in explaining the action mechanism of MG. The effectiveness of MG on hyperlipidemia is proved using the established metabolomic method and the regulated metabolic pathways involve the TCA cycle, taurine and hypotaurine metabolism, glyoxylate and dicarboxylate metabolism, glycine and serine and threonine metabolism, glycerophospholipid metabolism, primary bile acid biosynthesis etc. The results indicated that MG has a favourable protective effect on HFD-induced hyperlipidemia by adjusting the metabolic disorders. It also suggests that the metabolomic technology is a powerful approach for elucidation of the action mechanisms of MG.

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Section: Introductionmentioning

confidence: 99%

A high-throughput metabolomic approach to explore the regulatory effect of mangiferin on metabolic network disturbances of hyperlipidemia rats

Cheng-yan

et al. 2015

Mol. BioSyst.

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“…Based on TCM theory, yang deficiency is associated with signs of chronic, weak, hypofunction, hypometabolism, degenerative symptoms, and extremely common to be observed in late or severe stage of many diseases [48]. The metabolism pattern in CHF patients with yang deficiency and water retention syndrome demonstrated the decrease in glucose metabolism and the increase in lactate, alanine, and pyruvate, suggesting that the disorder of carbohydrate and energy metabolism in patients is more serious.…”

Section: Yang Deficiency and Water Retention Syndromementioning

confidence: 99%

Application of Metabolomics for the Diagnosis and Traditional Chinese Medicine Syndrome Differentiation of Chronic Heart Failure

Wang¹,

Chen²,

Zhao³

et al. 2016

Metabolomics - Fundamentals and Applications

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Chronic heart failure CHF was characterized by the failure of enough blood supply from the heart to meet the body's metabolic demands, and the prevalence of CHF continuously increases globally. The personalized diagnosis of Traditional Chinese Medicine TCM classiies CHF into several diferent syndrome types, and integrating Western and TCM to treat CHF has proved a validated therapeutic approach. Over the last few years, there has been a rapidly growing number of metabolomics applications aimed at inding biomarkers that could assist diagnosis, provide therapy guidance, and evaluate response to therapy for individualized intervention of CHF. Thus, in this review, particular atention will be paid to the past successes in applications of state-ofthe-art technology on metabolomics to contribute to biomarker discovery in CHF research.Keywords: metabolomics, chronic heart failure, Chinese Medicine . IntroductionChronic heart failure CHF , a progressive clinical syndrome characterized by the inability of the heart to adequately pump blood to meet metabolic demands of the body, represents the inal common ground of pathogenesis wherein various causes of heart damage converge [ ].© 2016 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.© 2016 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Despite a substantial improvement in the survival rate after the onset of CHF due to increasing use of pharmacological interventions, mortality of patients sufering from CHF remains high. Since it has been well recognized that the incidence and prevalence of CHF are expected to further increase with the aging of the population, beter strategy for the prevention and treatment of CHF patients is still needed. . . Epidemiology of CHFCHF, in recent years, has been a major cause of morbidity and mortality in the general population [ ]. "oth the increasing age of the population and success in the treatment of patients with acute myocardial infarction raise the prevalence and thus the economic expenditures of chronic heart failure [ ]. Heart failure is not only a common, costly, disabling, and potentially fatal condition but also the leading cause of hospitalization in people older than [ ]. In developing countries, % of the population sufers from heart failure, but in people from to years old, it occurs in % [ ]. In developed countries, around % of adults sufer from heart failure, but in people older than , this increases to % [ ]. . . Personalized intervention of CHF based on Traditional Chinese Medicine TCM syndromeWith progress being made in bioinformatics and m...

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“…Five therapeutic biomarkers (phosphate, betaine, (4-hydroxyphenyl) acetaldehyde, 5-hydroxyindol-3-acetic acid, and 5 0 -phosphoribosyl-N-formylglycinamide) and two corresponding canonical pathways (amino acid metabolism and purine nucleotide metabolism) were identified to be involved in the therapeutic mechanism of BFP treating the kidney-yang deficiency syndrome (KYDS) (Tan et al, 2014b).…”

Section: Functional Genomics and Metabolomicsmentioning

confidence: 99%

Chemical and biological studies of Aconitum pharmaceutical resources

Hao¹,

Gu²,

Xiao³

2015

Medicinal Plants

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Metabolic profiling reveals therapeutic biomarkers of processed Aconitum Carmichaeli Debx in treating hydrocortisone induced Kidney-Yang deficiency syndrome rats

Cited by 42 publications

References 63 publications

A high-throughput metabolomic approach to explore the regulatory effect of mangiferin on metabolic network disturbances of hyperlipidemia rats

A high-throughput metabolomic approach to explore the regulatory effect of mangiferin on metabolic network disturbances of hyperlipidemia rats

Application of Metabolomics for the Diagnosis and Traditional Chinese Medicine Syndrome Differentiation of Chronic Heart Failure

Chemical and biological studies of Aconitum pharmaceutical resources

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