Metabolic Profile of Clinically Severe Obese Patients

Abstract

The clinically severe obese patients showed low BMR levels when adjusted per kilogram per body weight. Body composition may influence BMR. The use of the MSJE formula may be helpful in those cases where it is impossible to use IC.

Intragastric balloon therapy leads to normalization of brain magnetic resonance spectroscopic markers of diabetes in morbidly obese patients

“…However, it should be noted that weight loss in general is associated with metabolic slowing exemplified by decrease in resting metabolic rate . Slowing of the metabolism results in slower weight loss and a risk of weight regain . Therefore, it is possible that (in general) patients with less slowing of metabolism have more weight loss and increases in tNAA/tCr, whereas patients with more pronounced slowing of metabolism experience less weight loss and decrease of tNAA/tCr.…”

The pathogenesis of obesity

“…Historically, it was believed that obesity was associated with "slow metabolism" due to lower RMR, AEE, and/or DIT contributing to a positive energy balance and subsequent weight gain [30]. Nonetheless, studies conducted over the past three decades have reported that absolute EE in obese individuals is in fact higher compared to their lean counterparts [43][44][45][46][47][48][49].…”

“…RMR is positively associated with weight [43][44][45][46][47][48]50,51] with reported differences up to 800 kcal/day when comparing individuals with a BMI N50 (RMR = 2157 kcal/day) to lean individuals (RMR = 1331 kcal/day) [47]. In obesity, increases in fat mass occur concurrently with increases in FFM [45].…”

Changes in resting metabolic rate and body composition due to intragastric balloon therapy

“…The mechanism of action likely involves stimulation of gastric mechanoreceptors triggering short-acting vagal signals to brain regions implicated in satiety [5]. Resting metabolic rate (RMR) is elevated among obese individuals; compared with healthyweight individuals it was shown to decrease with weight loss induced by dietary and/or physical activity interventions [6][7][8][9][10][11][12]. However, increases in RMR of individual patients were reported [13].…”

“…However, increases in RMR of individual patients were reported [13]. RMR divided by current weight (RMR/mass) [10,14] is lower among obese individuals, compared with individuals who are overweight or at normal weight [12]. After diet-restriction therapies accompanied by vigorous physical exercise, RMR/mass was reported to decrease [9] or increase (in an extreme case of 35% loss of initial weight) [7].…”