Metabolic Profile and Cardiovascular Risk in a Population of Renal Transplant Recipients

Gonçalves, Maria Conceição Rodrigues; Vieira, Pedro; Resende, Luís; Durães, José; Rosa, Nuno Guimarães; Teixeira, José Antônio Caldas; Silva, G.

doi:10.1016/j.transproceed.2015.03.031

Cited by 5 publications

(9 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While the prevalence of hypertension is between 21% and 26% in the general population, this rate varies between 67% and 86% in patients with ESRD. This is similar to our study data [16,18,19,24].…”

Section: Discussionsupporting

confidence: 93%

“…The age of kidney transplant in patients with ESRD varies between 43-50 years, and 58% -61% of these patients consist of male patients [15][16][17][18][19]. The age of the patients included in our study was found as 49 years in accordance with the literature, and 55% of them were male.…”

Section: Discussionsupporting

confidence: 80%

“…In this patient group, another important cardiovascular risk factor is smoking. Studies reveal that active smoking or the history of smoking is associated with the development of cardiovascular complications in the post-transplant period [19,22,23]. Gonçalves et al [19] reported that the 7-year all-cause mortality risk was higher than 10% in kidney transplant individuals who were smoking actively or who smoked in the past.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Cardiovascular diseases and risk factors in kidney transplant candidates

Kocabaş

2021

The European Research Journal

View full text Add to dashboard Cite

Objectives: Cardiovascular diseases and risk factors are associated with adverse cardiac events following kidney transplant. Therefore, pre-transplant evaluation of cardiovascular diseases and risk factors is important for determining the cardiac risk. The objective of this study is to determine the prevalence of cardiovascular diseases and risk factors in kidney transplant candidates. Methods: This is a single-center and observational study which includes 174 end-stage renal disease patients (male: 55.2% and mean age: 49 ± 13 years) who underwent kidney transplant. Preoperative clinical characteristics, cardiovascular diseases and risk factors of the patients were examined retrospectively. Results: The study population had multiple cardiovascular risk factors such as hypertension (66.7%), diabetes (28.2%), dyslipidemia (29.9%) and smoking (30.5%) in the evaluation conducted prior to kidney transplant. The most common cardiovascular diseases were detected as congestive heart failure (10.9%) and coronary artery disease (8.6%). The rate of the patients who underwent myocardial revascularization (percutaneous coronary intervention or coronary artery bypass grafting) before kidney transplant was 6.9%. The patients' mean left ventricular mass index was 114 ± 32 g/m2, and 55.5% of the study population had left ventricular hypertrophy. Conclusions: In our study, the prevalence of cardiovascular diseases and risk factors in the patients who underwent kidney transplant was found to be high.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cardiovascular diseases and risk factors in kidney transplant candidates

Kocabaş

2021

The European Research Journal

View full text Add to dashboard Cite

show abstract

“…Previously, a significant relation was found between cardiovascular risk, which increased similarly to that shown in our study, age, male sex, diabetes mellitus, and smoking habits before and after transplant. 15 We also observed that those who smoked for a long time were more likely to smoke after their surgical procedure.…”

Section: Discussionmentioning

confidence: 51%

Untitled

2016

Exp Clin Transplant

View full text Add to dashboard Cite

Objectives: Smoking is the most important remediable risk factor for the progression of renal diseases. Smoking has serious adverse effects, such as cardiovascular disease, kidney function impairment, and cancer in kidney transplant recipients who are already at high risk for these diseases. In this study, our objective was to evaluate descriptive characteristics and smoking status of renal transplant recipients. Materials and Methods: We evaluated 113 patients who underwent renal transplant at Baskent University Hospital between 1990 and 2015. The medical records of all patients were retrospectively reviewed. Patient demographics, cause of renal diseases, mortality status, smoking status, and amount of smoking were recorded. Results: In our study, 82 patients (72.7%) were male and 31 were female. The mean age was 38.50 ± 12.94 years. Causes of renal failure were as follows: 15.9% from hypertension, 12.4% from diabetes mellitus (all types), 8% from glomerulonephritis, 8% from vesicoureteral reflux, 6.2% from polycystic kidney disease, 17.6% other, and 31.9% unknown. Comorbid systemic disease was found in 57.6% of the patients. Fifty patients (44.2%) were current smokers, and 63 patients (55.8%) were nonsmokers. Mean age of smokers was 44.68 ± 10.60 years, with most being male patients (92.0%). There was a statistically significant difference between smoking status and sex (P < .001). The presence of comorbid diseases was significantly different between smokers and nonsmokers (P = .001). The smoking status of patients with hypertension (28.2%) was significantly different (P = .032) than others. Conclusions:Smoking cessation is associated with substantial health benefits for all smokers. For kidney transplant recipients, cigarette smoking has many adverse effects, causing cardiovascular disease and other comorbid diseases. Therefore, every attempt should be made to encourage kidney transplant candidates to stop smoking. Key words: Renal diseases, Smoking, Transplantation IntroductionSmoking is the most important risk factor in the progression of the renal diseases that can be corrected. In chronic renal diseases, cutting down on smoking is the most important factor in decreasing kidney malfunction. 1 Renal transplant recipients have a higher death rate related to diseases of cardiovascular origin than healthy individuals. 2 Smoking itself can be the main reason for cardiovascular mortality in renal transplant patients. Although chronic smoking increases proteinuria, it decreases renal plasma flow. 3 Although many argue that the nephrotoxic effects of smoking also affect renal transplant recipients, studies are scarce regarding the relation between smoking history and smoking habits and the smoking behaviors of patients on renal transplant wait lists. 2 The effect of smoking on the lifespan of renal transplant recipients has been evaluated by a limited number of studies. Because of cardiovascular diseases due to smoking, transplant recipients who smoke have a shorter lifespan. It is known that smoking befor...

show abstract

“…Pretransplant risk factors for CVEs include conventional demographic (and nonmodifiable) factors, such as age (young age in kidney transplantation and older age in liver transplantation), sex, race, preexisting conditions, such as diabetes, ischemic heart disease, duration of dialysis for kidney transplant recipients, smoking and general patient health (Figure 12). 289,292,313,314 Posttransplant risk factors for CVEs include NODAT, hypertension, impaired glucose tolerance, 288,289,292,315 impaired kidney function 295,316 and posttransplant hyperglycemia (Table 11 and Figure 12). 317,318 In clinical trials and registry studies in kidney transplantation, hypertension shows a strong association with major adverse cardiovascular event (MACE), as well as graft failure and mortality 289 ; increased systolic and pulse pressuremarkers of vascular stiffness-are specifically associated with cardiac death and stroke.…”

Section: Risk Factors For Cves In Kidney and Liver Transplant Recipientsmentioning

confidence: 99%

Practical Recommendations for Long-term Management of Modifiable Risks in Kidney and Liver Transplant Recipients

et al. 2017

View full text Add to dashboard Cite

Short-term patient and graft outcomes continue to improve after kidney and liver transplantation, with 1-year survival rates over 80%; however, improving longer-term outcomes remains a challenge. Improving the function of grafts and health of recipients would not only enhance quality and length of life, but would also reduce the need for retransplantation, and thus increase the number of organs available for transplant. The clinical transplant community needs to identify and manage those patient modifiable factors, to decrease the risk of graft failure, and improve longer-term outcomes. COMMIT was formed in 2015 and is composed of 20 leading kidney and liver transplant specialists from 9 countries across Europe. The group's remit is to provide expert guidance for the long-term management of kidney and liver transplant patients, with the aim of improving outcomes by minimizing modifiable risks associated with poor graft and patient survival posttransplant. The objective of this supplement is to provide specific, practical recommendations, through the discussion of current evidence and best practice, for the management of modifiable risks in those kidney and liver transplant patients who have survived the first postoperative year. In addition, the provision of a checklist increases the clinical utility and accessibility of these recommendations, by offering a systematic and efficient way to implement screening and monitoring of modifiable risks in the clinical setting. 12 Department of Gastroenterology and Hepatology, Erasmus MC, University Hospital Rotterdam, the Netherlands. 13 Department of Gastroenterology and Hepatology, University Hospitals KU Leuven, Belgium.14 Abdominal Transplant Surgery, Microbiology and Immunology Department, University Hospitals KU Leuven, Belgium. 15 Department of Hepatology and Liver Transplantation, Reina Sofía University Hospital, IMIBIC, CIBERehd, Spain. www.transplantjournal.com S1 S olid organ transplantation has evolved from an experimental procedure to an established treatment option for many types of end-stage organ failure. Both patient and graft outcomes are continuing to improve, and 1-year patient and graft survival currently exceed 80%.1,2 However, survival rates gradually decline over the long term. In kidney transplant, 5-and 10-year graft survival rates in Europe are 77% and 56%, and for liver transplant, 64% and 54% (Figures 1 and 2). 3,4 Although most European countries have seen an increase in both living and deceased donation, transplantation is not available to all who would benefit from the procedure, and there is considerable morbidity and mortality for those listed for transplant.6 Therefore, maximizing long-term graft survival and reducing the need for retransplantation is paramount, not only in improving outcomes for the recipients but also for those awaiting a graft. The improvement in outcomes is predominantly due to reduction in (Transplantation. 2017;101:S1-S41). The authors were approached by Astellas to discuss the practical implementation o...

show abstract

Metabolic Profile and Cardiovascular Risk in a Population of Renal Transplant Recipients

Cited by 5 publications

References 11 publications

Cardiovascular diseases and risk factors in kidney transplant candidates

Cardiovascular diseases and risk factors in kidney transplant candidates

Untitled

Practical Recommendations for Long-term Management of Modifiable Risks in Kidney and Liver Transplant Recipients

Contact Info

Product

Resources

About