Metabolic products of p,p′-DDT in the rat

Peterson, James E.; Robison, Wm.H.

doi:10.1016/0041-008x(64)90073-0

Cited by 167 publications

(33 citation statements)

References 2 publications

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“…Datta (1970) has suggested a pathway for pp'DDE metabolism in the rat similar to that postulated for pp'DDD metabolism (Peterson & Robison 1964). Perfusion studies by Nelson (1970) indicate possible involvement of the kidney in pp'DDE metabolism.…”

Section: Discussionmentioning

confidence: 99%

Failure of ethanol and phenobarbitone to reduce organochlorine pesticide residues in sheep

Ferry

McQueen

Owen

1973

New Zealand Journal of Agricultural Research

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Section: Discussionmentioning

confidence: 99%

Failure of ethanol and phenobarbitone to reduce organochlorine pesticide residues in sheep

Ferry

McQueen

Owen

1973

New Zealand Journal of Agricultural Research

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“…The possibility that DDT itself is the mutagenic agent is supported by the fact that treatment with DDT induced genetic effects in species as distant as mice and D. melanogaster. While the metabolism of DDT in these two species is distinctly different (Peterson and Robinson 1964;Fukuto and Metcalf 1969), and DDT remains the common factor in the assays, it is probably appropriate to suggest that DDT is the principle mutagen. However, the work of Vogel (1972) has shown that DDA, a metabolite of DDT, is weakly mutagenic in D. melanogaster.…”

Section: Discussionmentioning

confidence: 99%

Mutagenicity of DDT in Mice, Drosophila melanogaster and Neurospora crassa

Clark¹

1974

Aust. Jnl. Of Bio. Sci.

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The pesticide DDT was examined for possible mutagenicity in mice, D. melanogaster and N. crassa. Through the use of the dominant-lethal assay it was found that acute oral doses of DDT (2 x 150 mg/kg body weight) in male mice induced dominant lethal mutations in early spermatid and spermatocyte stages. Chronic oral doses of DDT (2 x 100 mg/kg body weight per week for 10 weeks) in male mice caused a persistent increase in the number of dominant lethal mutations. Histological sections showed that chronic treatment of mice with DDT caused changes in seminiferous tubule morphology and degeneration of B-type spermatogonia. Acute treatment of mice with DDT caused an increase in spermatocyte chromosome breakage, stickiness and precocious separation of the X and Y bivalent.Oral treatment of male Canton-S D. melanogaster with DDT caused an increase in dominant lethality in early spermatid and spermatocyte stages. DDT also caused non-disjunction of the X and Y chromosomes at the spermatocyte stage in treated male y/R(1)2,vj/B s yy+ D. melanogaster. The shift in sex ratio is discussed in terms of breakage of the ring-X chromosome. Treatment of a population of Canton-S D. melanogaster with DDT for eight months did not cause any increase in frequency of second-chromosome recessive lethal mutations.In tests for the induction of recessive lethal mutations in the ad-3 region of an N. crassa heterokaryon the results were inconclusive. However, in the host-mediated assay with N. crassa and mice as the host, DDT did not appear to be mutagenic.The results show that DDT has a deleterious effect on reproduction in mice and is a weak mutagen in both mice and D. melanogaster.

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“…In rats and humans, DDT is initially metabolized into DDE and DDD, and then DDE is slowly converted into 1-chloro-2,2-bis(pchlorophenyl)ethene (DDMU), while DDD is rapidly converted into DDMU (Morgan and Roan, 1971;Peterson and Robison, 1964). In mice and hamsters, DDT is initially metabolized exclusively to DDD, but no DDE is detected among metabolic products Brunk, 1982, 1983).…”

Section: Cyp5013c2 Is Involved In the Degradation Of Ddt To Dddmentioning

confidence: 99%

“…Reductive metabolism of DDT has been studied in several insects and mammalian species (Chiu et al, 2008;Brunk, 1982, 1983;Morgan and Roan, 1971;Peterson and Robison, 1964). In rats, cytochrome P450 monooxygenases (P450s) play important roles in the reductive dechlorination of DDT to DDD (Kitamura et al, 2002).…”

Section: Introductionmentioning

confidence: 99%