Metabolic products from Spicaria divaricataNRRI 5771.

Jiu, James; Mizuba, Seth

doi:10.7164/antibiotics.27.760

Cited by 17 publications

(8 citation statements)

References 4 publications

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“…Byssochlamys lagunculariae produces the same overall extrolite profile as B. nivea , except that patulin has not been detected in the former species. Byssochlamys spectabilis and isolates with only anamorphs ( P. variotii ) consistently produced viriditoxin, which was earlier reported from an isolate identified as Spicaria divaricata (Jiu & Mizuba 1974). Other unique extrolites were also produced but the structures of these have not yet been elucidated.…”

Section: Resultssupporting

confidence: 61%

“…Only the ex-type culture of B. zollerniae was available for study and some unique unknown extrolites were found in this isolate. In this study, we could not confirm viriditoxin production in P. divaricatus and assume that the strain studied by Jiu & Mizuba (1974) was probably a B. spectabilis isolate.…”

Section: Resultsmentioning

confidence: 71%

“…also produces mycotoxins (Scott 1965), such as patulin (Escoula 1975a, b), sphingofungin E and F (Frommer et al 1992) and viriditoxin, reported originally from an isolate named Spicaria divaricata (Jiu & Mizuba 1974). Apart from being reported as being a potential mycotoxin, viriditoxin has also been reported to be a candidate for treatment of antibiotic resistant bacteria (Wang et al 2003).…”

Section: Discussionmentioning

confidence: 99%

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Polyphasic taxonomy of the heat resistant ascomycete genus Byssochlamys and its Paecilomyces anamorphs

Samson¹,

Houbraken²,

Varga³

et al. 2009

Pers - Int Mycol J

135

123

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Byssochlamys and related Paecilomyces strains are often heat resistant and may produce mycotoxins in contaminated pasteurised foodstuffs. A comparative study of all Byssochlamys species was carried out using a polyphasic approach to find characters that differentiate species and to establish accurate data on potential mycotoxin production by each species. Phylogenetic analysis of the ITS region, parts of the β-tubulin and calmodulin genes, macro- and micromorphological examinations and analysis of extrolite profiles were applied. Phylogenetic analyses revealed that the genus Byssochlamys includes nine species, five of which form a teleomorph, i.e. B. fulva, B. lagunculariae, B. nivea, B. spectabilis and B. zollerniae, while four are asexual, namely P. brunneolus, P. divaricatus, P. formosus and P. saturatus. Among these, B. nivea produces the mycotoxins patulin and byssochlamic acid and the immunosuppressant mycophenolic acid. Byssochlamys lagunculariae produces byssochlamic acid and mycophenolic acid and thus chemically resembles B. nivea. Some strains of P. saturatus produce patulin and brefeldin A, while B. spectabilis (anamorph P. variotii s.s.) produces viriditoxin. Some micro- and macromorphological characters are valuable for identification purposes, including the shape and size of conidia and ascospores, presence and ornamentation of chlamydospores, growth rates on MEA and CYA and acid production on CREA. A dichotomous key is provided for species identification based on phenotypical characters.

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Section: Resultssupporting

confidence: 61%

Section: Resultsmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Polyphasic taxonomy of the heat resistant ascomycete genus Byssochlamys and its Paecilomyces anamorphs

Samson¹,

Houbraken²,

Varga³

et al. 2009

Pers - Int Mycol J

135

123

View full text Add to dashboard Cite

show abstract

“…69 Viriditoxin 38 shows activity against a range of bacterial pathogens including methicillin-resistant and methicillin-sensitive strains of Staphylococcus aureus (MIC 4-8 mg mL À1 ) and vancomycin-resistant and vancomycin-sensitive Enterococcus faecalis and Enterococcus faecium (MIC 2-16 mg mL À1 ). SC-28763 40 and SC-30532 41 were isolated from Spicaria divaricata, 65,71 along with the related metabolite SC-28762 that is structurally identical to viriditoxin 38. It is phytotoxic to Cucumis sativus (cucumber), weakly antibacterial and antifungal and is lethal to Artemia salina shrimp at 0.1 mM.…”

Section: Toralactone-based Naphthopyranonesmentioning

confidence: 99%

Naphthopyranones – isolation, bioactivity, biosynthesis and synthesis

Donner

2015

Nat. Prod. Rep.

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The 1H-naphtho[2,3-c]pyran-1-one (naphthopyranone) moiety forms the structural framework of a group of secondary metabolites that have been isolated from a range of organisms including fungi, bacteria, lichen and plants. This review documents the known naturally occurring naphthopyranones - their isolation, biosynthesis and biological activity. A survey of methods reported for the synthesis of naphthopyranone natural products is presented.

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“…18,19 Viriditoxin (2) was first isolated from Aspergillus viridinutans as a mycotoxin, whereas it was later also obtained from Aspergillus brevipes, Aspergillus fumigatus, Paecilomyces variotii and Spicaria divaricata. [18][19][20] Details on the isolation and structure elucidation of 1, its biological activity and the plausible biogenesis of the isolated compounds are reported herein.…”

Section: Introductionmentioning

confidence: 99%

Cladosporinone, a new viriditoxin derivative from the hypersaline lake derived fungus Cladosporium cladosporioides

et al. 2016

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A new cytotoxic viriditoxin derivative, cladosporinone (1), along with the known viriditoxin (2) and two viriditoxin derivatives (3 and 4) were obtained from the fungus Cladosporium cladosporioides isolated from the sediment of a hypersaline lake in Egypt. The structure of the new compound (1) was determined by 1D and 2D NMR measurements as well as by high-resolution ESIMS and electronic circular dichroism spectroscopy. All isolated compounds were studied for their cytotoxicity against the murine lymphoma cell line L5187Y and for their antibiotic activity against several pathogenic bacteria. Viriditoxin (2) was the most active compound in both bioassays. Compound 1 also exhibited strong cytotoxicity against the murine lymphoma cell line L5187Y with an IC50 value of 0.88 μm, whereas its antibiotic activity was weak.

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Metabolic products from Spicaria divaricataNRRI 5771.

Cited by 17 publications

References 4 publications

Polyphasic taxonomy of the heat resistant ascomycete genus <I>Byssochlamys</I> and its <I>Paecilomyces</I> anamorphs

Polyphasic taxonomy of the heat resistant ascomycete genus <I>Byssochlamys</I> and its <I>Paecilomyces</I> anamorphs

Naphthopyranones – isolation, bioactivity, biosynthesis and synthesis

Cladosporinone, a new viriditoxin derivative from the hypersaline lake derived fungus Cladosporium cladosporioides

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