1959
DOI: 10.1016/0006-3002(59)90460-3
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Metabolic pools and the synthesis of macromolecules

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Cited by 126 publications
(37 citation statements)
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“…Uptake of 5-FC-2-,JC in C. albicans, distribution of radioactivity in the expandable pool, internal pool (as defined by C ow ie and M cC lure [1]; Kempner [7]), and RNA (see 'Materials and Methods'), as well as incor poration of the drug into rRNA and tRNA, were investigated as influenced by Ade, Urd or Cyt, which had exhibited the strongest -and, as far as Ade is concerned, most surprising -antagonism against 5-FC in the reversal experiments reported before [14], The uptake and distribution of radiolabelled 5-FC were first checked in the stationary growth phase of the yeast, i.e., at the same time as the fungistatic and antagonistic effects described in our previous paper [ 14]. By uptake, we mean the total radio active compond(s) found in the yeast cells after the particular period of incubation.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Uptake of 5-FC-2-,JC in C. albicans, distribution of radioactivity in the expandable pool, internal pool (as defined by C ow ie and M cC lure [1]; Kempner [7]), and RNA (see 'Materials and Methods'), as well as incor poration of the drug into rRNA and tRNA, were investigated as influenced by Ade, Urd or Cyt, which had exhibited the strongest -and, as far as Ade is concerned, most surprising -antagonism against 5-FC in the reversal experiments reported before [14], The uptake and distribution of radiolabelled 5-FC were first checked in the stationary growth phase of the yeast, i.e., at the same time as the fungistatic and antagonistic effects described in our previous paper [ 14]. By uptake, we mean the total radio active compond(s) found in the yeast cells after the particular period of incubation.…”
Section: Discussionmentioning
confidence: 99%
“…Further samples of the C. albicans cells were consecutively processed for the extraction of (1) the expandable pool, (2) the internal pool [1,7], and (3) the 'RNA fraction' = cold TCA insoluble fraction (see below): They were (1) extracted with water and (2) with cold 5% TCA. Both liquids were evaporated in the vacuum oven and the residue was redissolved in 2.0 ml distilled water, 0.5-ml aliquots of which were pipetted on ash-free filter tablets (Schleicher & Schiill).…”
Section: Uptake and Distribution Of S-fc-2-4cmentioning
confidence: 99%
“…Nous en sommes ainsi venus à nous demander si les vacuoles emmagasinent des acides aminés. L'existence de «pools» de stockage et de «pools» métaboliques d'acides aminés a été postulée plusieurs fois par l'analyse de données cinétiques à l'aide de marquages radioactifs (Cowie et McClure, 1959).…”
Section: * **unclassified
“…Various kinetic studies have well-documented the concept of metabolic pools within an organism, although their location within the cell is by no means positively established (Zalokar, 1961 ;Steward & Bidwell, 1962;Oaks, 1965). Two amino acid pools are generally recognized, an 'expandable' pool into which exogenous amino acids are accumulated and an 'internal' pool closely associated with protein synthesis (Cowie & McClure, 1959). Dawson (1965), experimenting with Candidu utilis, has shown that the second pool was not related to the amount of protein synthesis within the cell and has envisaged a pool of 'activated' amino acids.…”
Section: Integration Into Cellular Metabolismmentioning
confidence: 99%