Abstract:It is generally agreed that the metabolic pathway of a drug and its thera peutic activity are relatcd1 2. Some years ag03 metabolic studi e s on the two tuberculostatics 4-pyridyl-oxadiazolone5 and isoniazid, showed that both substances gave in the rat three identical metabolites. This fact was considered sufficient evidence to draw the conc1usion that 4-pyridyl oxadiazolone was metabolised in the body via isoniazid, which latter would be responsible for the tuberculostasis. The two drugs would be therefore cl… Show more
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