Metabolic partitioning in the brain and its hijacking by glioblastoma
Jed de Ruiter Swain,
Evdokia Michalopoulou,
Evan K. Noch
et al.
Abstract:The different cell types in the brain have highly specialized roles with unique metabolic requirements. Normal brain function requires the coordinated partitioning of metabolic pathways between these cells, such as in the neuron–astrocyte glutamate–glutamine cycle. An emerging theme in glioblastoma (GBM) biology is that malignant cells integrate into or “hijack” brain metabolism, co-opting neurons and glia for the supply of nutrients and recycling of waste products. Moreover, GBM cells communicate via signalin… Show more
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