Metabolic Parameters in Women with Metastatic Breast Cancer

Carter, Anne C.; Lefkon, Bruce W.; Farlin, M.E.; Feldman, Elaine B.

doi:10.1210/jcem-40-2-260

Cited by 24 publications

(7 citation statements)

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“…Breast cancer and genital cancer "is far lower in allergic and hyperthyroid conditions ..... than in hypothyroid women or women after a partial thyroidectomy"; Loeser (1954) continues "the more thyroid hormone circulating in the blood ..... the less tendency to cancer formation". Conversely, hyperthyroidism has been associated with the development of breast cancer in premenopausal women (Berndt and Lattermann, 1969); however, plasma levels of thyroid hormone were normal in patients with breast cancer (Carter et al, 1975). According to Moossa et al (1973) no association exists between breast cancer and any type of thyroid disease.…”

Section: Hyperthyroidism and Risk Of Breast Cancermentioning

confidence: 99%

Thyroid disease in relation to breast cancer

Vorherr

1978

Klin Wochenschr

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A controversy exists in regard to thyroid function and breast cancer. Hypothyroidism has been suggested as being either protective from breast cancer or predisposing to the disease. It has been hypothesized that a deficiency in circulating thyroid hormones may hypersensitize the mammary glandular epithelium toward prolactin and estrogens, thus aiding the development of breast neoplasia. On the other hand, thyroid hormone replacement therapy has been connected with an increased risk of breast cancer, but this has been contested. At this time the American Thyroid Association recommends that, if indicated, hypothyroid patients should take their thyroid hormone medication. Hyperthyroidism has been associated with a decreased risk of breast cancer. Also, in hyperthyroid patients with inoperable breast cancer, the malignant growth is thought to be slowed. However, this, too has been disputed. Moreover, hyperthyroidism has been connected with the development of breast cancer in premenopausal women. At present no role of thyroid hormone in the pathobiology of breast cancer can be defined. It seems that the "thyroid-breast cancer controversy" can only be resolved by a prospective study preferably on postmenopausal women correlating thyroid (T3, T4, PBI), pituitary (TSH, TRH, Prolactin), and adrenocortical (androgens) function tests with the clinical examination of thyroid, breast, and genital apparatus and determination of the estrogen status (vaginal smear, plasma estrogens) as well.

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Section: Hyperthyroidism and Risk Of Breast Cancermentioning

confidence: 99%

Thyroid disease in relation to breast cancer

Vorherr

1978

Klin Wochenschr

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“…Since many years it was also recognized that the presence of a cancerous tumor could induce global and systemic alterations in the patient's metabolism. However the mechanisms allowing a few cells to influence the whole metabolism were largely unknown [ 28 , 29 , 43 , 44 ]. Recently it was even suggested that solid tumor behave as systemic metabolic dictators and the molecular basis of cancer cachexia have been outlined [ 45 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

Does the 1H-NMR plasma metabolome reflect the host-tumor interactions in human breast cancer?

et al. 2017

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Breast cancer (BC) is the most common diagnosed cancer and the leading cause of cancer death in women worldwide. There is an obvious need for a better understanding of BC biology. Alterations in the serum metabolome of BC patients have been identified but their clinical significance remains elusive. We evaluated by 1H-Nuclear Magnetic Resonance (1H-NMR) spectroscopy, filtered plasma metabolome of 50 early (EBC) and 15 metastatic BC (MBC) patients. Using Principal Component Analysis, Partial Least-Squares Discriminant Analysis and Hierarchical Clustering we show that plasma levels of glucose, lactate, pyruvate, alanine, leucine, isoleucine, glutamate, glutamine, valine, lysine, glycine, threonine, tyrosine, phenylalanine, acetate, acetoacetate, β-hydroxy-butyrate, urea, creatine and creatinine are modulated across patients clusters. In particular lactate levels are inversely correlated with the tumor size in the EBC cohort (Pearson correlation r = −0.309; p = 0.044). We suggest that, in BC patients, tumor cells could induce modulation of the whole patient's metabolism even at early stages. If confirmed in a lager study these observations could be of clinical importance.

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“…These have been reported variously as impaired glucose tolerance [77][78][79], decreased insulin sensitMty [8,80], decreased insulin release in response to a glucose load [77,79], and decreased activity of energy producing enzymes in skeletal muscle [79]. Fasting plasma alanine levels are significantly decreased, while branched chain amino acids are unchanged.…”

Section: Changes In Energy Expenditurementioning

confidence: 99%

Malignant disease: nutritional implications of disease and treatment

Holmes

Dickerson

1987

Cancer Metast Rev

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Protein-energy malnutrition (PEM) is common in cancer patients and may develop into the syndrome known as 'cancer cachexia'. This is characterised by complex disturbances in carbohydrate, lipid, protein, and electrolyte metabolism. The aetiology is equally complex, with host and therapeutic factors contributing to the reduced food intake and effects on host tissues. Anorexia is of prime importance, differing in its cause from one patient to another and often presenting a barrier to successful nutritional support. Further research is necessary to elucidate the interaction of central and peripheral factors that may be involved in the aetiology of anorexia. Because of the interplay of biochemical, physiological, and psychological consequences of cancer, the nutritional support of the patient presents a considerable challenge to the caring professions.

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Metabolic Parameters in Women with Metastatic Breast Cancer

Cited by 24 publications

References 0 publications

Thyroid disease in relation to breast cancer

Thyroid disease in relation to breast cancer

Does the 1H-NMR plasma metabolome reflect the host-tumor interactions in human breast cancer?

Malignant disease: nutritional implications of disease and treatment

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