Metabolic Messengers: FGF21

Flippo, Kyle H.; Potthoff, Matthew J.

doi:10.1038/s42255-021-00354-2

Cited by 146 publications

(151 citation statements)

References 135 publications

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“…In females, as in males, administration of FGF21 reduced body weight and blood levels of cholesterol, glucose, and insulin. FGF21 can induce weight loss in different ways: by increasing energy expenditure through thermogenesis, by increasing physical activity, and, in some cases, by reducing food intake [ 50 ]. In this experiment, a decrease in fat mass was associated with an increase in energy expenditure, because energy consumption did not decrease but rather increased during the experiment, and FGF21 did not affect locomotor activity.…”

Section: Discussionmentioning

confidence: 99%

The Same Metabolic Response to FGF21 Administration in Male and Female Obese Mice Is Accompanied by Sex-Specific Changes in Adipose Tissue Gene Expression

Макарова

Kazantseva

Dubinina

et al. 2021

IJMS

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The preference for high-calorie foods depends on sex and contributes to obesity development. Fibroblast growth factor 21 (FGF21) beneficially affects taste preferences and obesity, but its action has mainly been studied in males. The aim of this study was to compare the effects of FGF21 on food preferences and glucose and lipid metabolism in C57Bl/6J male and female mice with diet-induced obesity. Mice were injected with FGF21 or vehicle for 7 days. Body weight, choice between standard (SD) and high-fat (HFD) diets, blood parameters, and gene expression in white (WAT) and brown (BAT) adipose tissues, liver, muscles, and the hypothalamus were assessed. Compared to males, females had a greater preference for HFD; less WAT; lower levels of cholesterol, glucose, and insulin; and higher expression of Fgf21, Insr, Ppara, Pgc1, Acca and Accb in the liver and Dio2 in BAT. FGF21 administration decreased adiposity; blood levels of cholesterol, glucose, and insulin; hypothalamic Agrp expression, increased SD intake, decreased HFD intake independently of sex, and increased WAT expression of Pparg, Lpl and Lipe only in females. Thus, FGF21 administration beneficially affected mice of both sexes despite obesity-associated sex differences in metabolic characteristics, and it induced female-specific activation of gene expression in WAT.

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Section: Discussionmentioning

confidence: 99%

The Same Metabolic Response to FGF21 Administration in Male and Female Obese Mice Is Accompanied by Sex-Specific Changes in Adipose Tissue Gene Expression

Макарова

Kazantseva

Dubinina

et al. 2021

IJMS

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show abstract

Section: Introductionmentioning

confidence: 99%

“…Fibroblast growth factor 21 (FGF21) is a human metabolic hormone that is expressed in the liver [ 1 ]. The effects of FGF21 include altering of macronutrient preference and energy homeostasis [ 1 , 2 , 3 ]. Increased circulating FGF21 decreases the consumption of sweets, sugar and alcohol [ 2 , 4 , 5 ], and indirectly increases protein intake by suppressing sugar consumption [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Genetic Evidence Supporting Fibroblast Growth Factor 21 Signalling as a Pharmacological Target for Cardiometabolic Outcomes and Alzheimer’s Disease

Larsson

2021

Nutrients

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Fibroblast growth factor 21 (FGF21) is a human metabolic hormone whose effects include modification of macronutrient preference and energy homeostasis. In animal models, FGF21 has been shown to have beneficial effects on cardiometabolic outcomes, Alzheimer’s disease risk and lifespan. In this study, the single-nucleotide polymorphism rs838133 in the FGF21 gene region was leveraged to investigate the potential clinical effects of targeting FGF21. The FGF21 G allele was associated with lower intakes of total sugars and alcohol, and higher intakes of protein and fat as well as favourable with lipid levels, blood pressure traits, waist-to-hip ratio, systemic inflammation, cardiovascular outcomes, Alzheimer’s disease risk and lifespan. These findings may be used to anticipate the effects of pharmacologically increasing FGF21 signalling.

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“…FGF21 binds preferentially to FGFR1c und FGFR3c subtypes [16,17]. However, FGFR1c is the only FGFR subtype which mediates a relevant activation of FGF21 [5,[18][19][20]. This has been demonstrated by the finding that genetic ablation of FGFR1 causes a complete loss of FGF21 signaling in mice [21].…”

Section: Current Knowledge About Fgf21 Function In Humans and Micementioning

confidence: 99%

“…In addition, FGF21 is induced by various stress conditions such as environmental stress (cold), nutritional stress (fasting, malnutrition, high fat diet, obesity, amino acid deprivation) or exercise in order to cope with the energy consuming stress response by increasing availability of energy substrates [4]. In this context, FGF21 is understood as a hormone which, depending on the metabolic state, instructs the organism to reestablish homeostasis through actions on multiple tissues [5]. While the functions of FGF21 in humans and animal models, particularly mice, are increasingly understood, the knowledge about the role of FGF21 in livestock species is still limited.…”

Section: Introductionmentioning

confidence: 99%

Fibroblast growth factor 21 in dairy cows: current knowledge and potential relevance

Eder

Geßner

Ringseis

2021

J Animal Sci Biotechnol

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Fibroblast growth factor 21 (FGF21) has been identified as an important regulator of carbohydrate and lipid metabolism, which plays an important role for metabolic regulation, particularly under conditions of energy deprivation or stress conditions. Dairy cows are subjected to a negative energy balance and various kinds of stress particularly during the periparturient phase and during early lactation. It has been shown that the plasma concentration of FGF21 in dairy cows is dramatically increased at parturition and remains high during the first weeks of lactation. This finding suggests that FGF21 might exert similar functions in dairy cows than in other species, such as mice or humans. However, the role of FGF21 in dairy cows has been less investigated so far. Following a brief summary of the previous findings about the function of FGF21 in humans and mice, the present review aims to present the current state of knowledge about the role of FGF21 in dairy cows. The first part of the review deals with the tissue localization of FGF21 and with conditions leading to an upregulation of FGF21 expression in the liver of dairy cows. In the second part, the influence of nutrition on FGF21 expression and the role of FGF21 for metabolic diseases in dairy cows is addressed. In the third part, findings of exogenous FGF21 application on metabolism in dairy cows are reported. Finally, the potential relevance of FGF21 in dairy cows is discussed. It is concluded that FGF21 might be of great importance for metabolic adaptation to negative energy balance and stress conditions in dairy cows. However, further studies are needed for a better understanding of the functions of FGF21 in dairy cows.

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Metabolic Messengers: FGF21

Cited by 146 publications

References 135 publications

The Same Metabolic Response to FGF21 Administration in Male and Female Obese Mice Is Accompanied by Sex-Specific Changes in Adipose Tissue Gene Expression

The Same Metabolic Response to FGF21 Administration in Male and Female Obese Mice Is Accompanied by Sex-Specific Changes in Adipose Tissue Gene Expression

Genetic Evidence Supporting Fibroblast Growth Factor 21 Signalling as a Pharmacological Target for Cardiometabolic Outcomes and Alzheimer’s Disease

Fibroblast growth factor 21 in dairy cows: current knowledge and potential relevance

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