Abstract:The high prevalence of cannabis use, the most consumed psychoactive drug in the world, is associated with increased usage by pregnant women, especially during the first trimester of pregnancy. However, while cannabinoid receptors are expressed in the early embryo, the impact of phytocannabinoids exposure on early embryonic processes is severely lacking. Here, we leverage a stepwise in vitro differentiation system that captures the early embryonic developmental cascade bridging embryonic stem cells and primordi… Show more
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