Metabolic Mechanisms in Tolerance and Physical Dependence on Alcohol

Eriksson, C. J. Peter; Deitrich, Richard A.

doi:10.1007/978-1-4613-3518-4_8

Cited by 6 publications

(3 citation statements)

References 148 publications

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“… 27 , 28 , 29 , 30 Chronic alcoholics have a higher tolerance to alcohol than others because of the metabolic adaptation of the central nervous system and increased ethanol elimination rate. 31 Increased ethanol elimination increases both blood and tissue acetaldehyde levels in chronic alcoholics. 32 People with liver injury experience decreasing activities of ADH and proportionally low‐K ALDH (ALDH2).…”

Section: Discussionmentioning

confidence: 99%

“…Some studies showed that the genotype of ADH and ALDH was associated with liver disease 27,28–30 . Chronic alcoholics have a higher tolerance to alcohol than others because of the metabolic adaptation of the central nervous system and increased ethanol elimination rate 31 . Increased ethanol elimination increases both blood and tissue acetaldehyde levels in chronic alcoholics 32 .…”

Section: Discussionmentioning

confidence: 99%

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Association between changes in facial flushing and hypertension across drinking behavior patterns in South Korean adults

Park

Kang

Park

et al. 2022

J of Clinical Hypertension

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Heavy alcohol drinking has been reported to be associated with hypertension. Moreover, when drinking alcohol, individuals may experience symptoms such as facial flushing. Therefore, this study aimed to examine the association between changes in facial flushing and hypertension across different drinking behavior patterns in South Korean adults. Data from the Korea Community Health Survey conducted in 2019 were used, and 118 129 (51 047 men and 67 082 women) participants were included. The participants were divided into five groups based on the change in facial flushing (non-drinking, nonflushing to non-flushing, flushing to flushing, non-flushing to flushing, flushing to nonflushing). The risk of hypertension in each facial flushing group was analyzed by multiple logistic regression.Men in the non-flushing to flushing group had a significantly higher association with hypertension than other groups (men: odds ratio (OR) 1.42, confidence interval (CI) 1. 14-1.76). According to the level of alcohol use disorder, the non-flushing to flushing group showed a significantly increased odds of hypertension compared to all levels of drinking (men: mild drinking:

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association between changes in facial flushing and hypertension across drinking behavior patterns in South Korean adults

Park

Kang

Park

et al. 2022

J of Clinical Hypertension

View full text Add to dashboard Cite

show abstract

“…These data are in line with the data obtained in patients with chronic alcoholism. They show greater tolerance to alcohol due to an increase in the alcohol elimination rate and metabolic tolerance (41). Previous animal studies also confirm this hypothesis as alcohol-preferring rats are characterized by a significantly lower blood alcohol concentration compared to non-preferring controls (42), probably due to more rapid alcohol metabolism and higher activity of alcohol dehydrogenase (43).…”

Section: Discussionmentioning

confidence: 99%

Enhanced Alcohol Preference and Anxiolytic Alcohol Effects in Niemann-Pick Disease Model in Mice

et al. 2019

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Major depression and alcohol use disorder are severe psychiatric diseases affecting the world's population with high comorbidity level. However, the pathogenesis of this comorbidity remains unclear, and no selective treatment for this condition is available. A pathogenic pathway and a possible therapeutic target for the treatment of depression-alcoholism comorbidity based on the hyperfunction of acid sphingomyelinase (Asm) were recently suggested. Here we analyzed the effects of alcohol on the depression/anxiety state of homozygous Asm-knockout mice (Asm − /−), which can be considered as a model of an early stage of Niemann-Pick disease, as well as their drinking pattern under normal and stress conditions. It was observed that forced treatment with alcohol (2 g/kg, i.p.) reduces the anxiety level of Asm−/− mice as measured in the elevated plus maze (EPM) test, but enhances the depression level in the forced swim test (FST). The analysis of drinking pattern of these animals in a free-choice alcohol drinking paradigm revealed higher alcohol intake and preference in Asm−/− mice compared to wild type (wt) littermates. However, this difference was overwritten by the stress exposure. Stronger sedating effects of alcohol were observed in Asm−/− mice compared to wt animals in the loss of righting reflex test after single and repeated alcohol injections (3 g/kg, i.p.). Altogether, the present findings might indicate an Asm involvement in the mechanisms of comorbidity between alcoholism and anxiety/depression.

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Brain free amino acid pool in rats differing in preference for ethanol

Ostrovskii¹,

Kiianmaa²

1990

Bull Exp Biol Med

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Metabolic Mechanisms in Tolerance and Physical Dependence on Alcohol

Cited by 6 publications

References 148 publications

Association between changes in facial flushing and hypertension across drinking behavior patterns in South Korean adults

Association between changes in facial flushing and hypertension across drinking behavior patterns in South Korean adults

Enhanced Alcohol Preference and Anxiolytic Alcohol Effects in Niemann-Pick Disease Model in Mice

Brain free amino acid pool in rats differing in preference for ethanol

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