Metabolic impairments and tissue disorders in alloxan-induced diabetic rats are alleviated by Salvia officinalis L. essential oil

Belhadj, Sahla; Hentati, Olfa; Hammami, Majdi; Hadj, Aïda Ben; Boudawara, Tahia; Dammak, M.; Zouari, Sami; Feki, Abdelfattah El

doi:10.1016/j.biopha.2018.09.108

Cited by 30 publications

(22 citation statements)

References 51 publications

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“…S. officinalis has a high concentration of camphor composition (Cutillas et al, 2017; El Euch et al, 2019; Khedher et al, 2017). Extract of this plant exhibited a decreasing effect on serum glucose, TC, TC, urea, creatinine, and aminotransferases (AST and ALT) and an increasing effect on plasma insulin in diabetic rats (Belhadj et al, 2018; Eidi & Eidi, 2009). In another study on Artemisia plant, it was shown that various concentrations of aqueous and ethanolic extracts of this plant decrease the blood glucose and serum levels of TG and TC, uric acid, creatinine, and weight gain (Helal et al, 2014; Juteau et al, 2002; Nofal et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Modulation of the antioxidant defense system in liver, kidney, and pancreas tissues of alloxan‐induced diabetic rats by camphor

2020

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Excess production of reactive oxygen species and the loss of antioxidant efficiency systems play an important role in the development of diabetes. Thus, using antioxidant compounds is an important strategy to reduce these complications. This study aimed to investigate the possible effect of camphor on the serum biochemical parameters and oxidative parameters in the pancreas, liver, and kidney tissues of alloxaninduced diabetic rats. In this study, 40 male Wistar rats were divided into five groups, including normal group, diabetic group, the diabetic group treated with glibenclamide, the diabetic group treated with 30 mg/kg camphor, and the diabetic group receiving the camphor solvent. Intragastric administration of camphor and glibenclamide, as the control drug, to diabetic rats for 21 days lowered their blood glucose, total cholesterol, triglyceride, and LDL-cholesterol, while the blood high-density lipoprotein-cholesterol level was increased. In addition, our results indicated that treatment of diabetic rats with camphor increased the activity of glutathione peroxidase, catalase, and superoxide dismutase enzymes as well as reduced glutathione content in the liver, pancreas, and kidney tissues as compared to the diabetic rats. Based on our data, it can be concluded that camphor has a hypoglycemic activity, and this effect may be attributed, in part, to its antioxidant ability.

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Section: Discussionmentioning

confidence: 99%

Modulation of the antioxidant defense system in liver, kidney, and pancreas tissues of alloxan‐induced diabetic rats by camphor

2020

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“…Several plants rich in terpenes, such as sesquiterpenes found in C. xanthocarpa have been shown an effect on blood glucose levels (Alam et al, 2018;Belhadj et al, 2018). Considering the presence of terpenoids in the extract, among them the caryophyllene that previously demonstrated anti-diabetic activity (Basha and Sankaranarayanan, 2014), the observed effect on glycemia may be due to the presence of these compounds.…”

Section: Effect Of Campomanesia Xanthocarpa Seeds Extract On Oral Glumentioning

confidence: 98%

Antidiabetic and hypolipidemic potential of Campomanesia xanthocarpa seed extract obtained by supercritical CO2

et al. 2021

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Campomanesia xanthocarpa, a plant belonging to the Myrtaceae family, is popularly known as gabiroba. Leaves of gabiroba has been popularly used to treat various diseases, including inflammatory, renal, and digestive, among others. Additionally, studies have shown an effect to reduce blood cholesterol levels. The aim of this study was to evaluate the antihyperglycemic and hypolipidemic effects of Campomanesia xanthocarpa seed extract in hyperglycemic rats. The results showed that 400 mg/kg of seed extract was able to decrease blood glucose levels and to increase the muscular and hepatic glycogen content as well as to inhibit the sucrase and maltase activity. At doses of 200 mg/kg and 800 mg/kg, the activity of these enzymes was also reduced. In the lipid profile 400 mg/kg produced a decrease in total and LDL cholesterol serum levels; and with 200 mg/kg there was an increase in HDL cholesterol levels. The extract did not present hepatic and renal toxic effects at the different doses tested. The results suggest that the treatment with Campomanesia xanthocarpa seeds extract is useful in reducing glycemia, total cholesterol and LDL levels with potential adjuvant therapeutic in the treatment of diabetes and hypercholesterolemia, however, additional pharmacological and toxicological studies are still required.

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“…These observed effects of SEO were comparable to those of glimepiride. As diabetes often comes along with obesity the lipase inhibitory effects of SEO seems to be very promising for therapeutic treatment [58].…”

Section: Sage Essential Oilmentioning

confidence: 99%

“…In contrast to the infant, the cramps occurred more than once in the new-born, but both weathered it well [110]. However, it has to be considered that thujone is not the only convulsant compound in SEO, since camphor (discussed in Chapter 3.4) and 1,8-cineol are contained, too [58,104,110]. Although human studies are very rare and often inconclusive [111], the Scientific Committee of Food (SCF) decided that the sensitivity of humans to thujone is comparable to that of animals.…”

Section: Thujonementioning

confidence: 99%

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Selected essential oils and their mechanisms for therapeutic use against public health disorders. An overview

Leherbauer

Stappen

2020

Zeitschrift Für Naturforschung C

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AbstractToday, the numbers of people suffering from lifestyle diseases like diabetes, obesity, allergies and depression increases mainly in industrialised states. That does not only lower patients’ quality of life but also severely stresses the health care systems of these countries. Essential oils (EO) have been in use as therapeutic remedies for centuries against various complaints, but still their effectiveness is being underestimated. In the last decades, a great number of controlled studies have supported efficacy of these volatile secondary plant metabolites for various therapeutic indications. Besides others, EO has antidepressant, anti-obesity, antidiabetic, antifirogenic and antiallergic effects. In this review the pharmacological mechanisms for selected EO are summarised and discussed with the main attention on their impact against public health disorders. Additionally, toxicity of these oils as well as possible drug interactions is presented.

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Metabolic impairments and tissue disorders in alloxan-induced diabetic rats are alleviated by Salvia officinalis L. essential oil

Cited by 30 publications

References 51 publications

Modulation of the antioxidant defense system in liver, kidney, and pancreas tissues of alloxan‐induced diabetic rats by camphor

Modulation of the antioxidant defense system in liver, kidney, and pancreas tissues of alloxan‐induced diabetic rats by camphor

Antidiabetic and hypolipidemic potential of Campomanesia xanthocarpa seed extract obtained by supercritical CO2

Selected essential oils and their mechanisms for therapeutic use against public health disorders. An overview

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