Metabolic impact of current therapeutic strategies in Polycystic Ovary Syndrome: a preliminary study

Diego, María Victoria De; Gómez-Pardo, Olga; Groar, Janette Kirk; López-Escobar, Alejandro; Martín-Estal, Irene; Castilla‐Cortázar, Inma; Rodríguez-Zambrano, Miguel Ángel

doi:10.1007/s00404-020-05696-y

Cited by 16 publications

(12 citation statements)

References 49 publications

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“…Newer data are from studies that included a metformin arm compared to another medication, which show minimal weight loss when added to a COCP [41], or increased weight loss in women with PCOS and obesity who received 1500 mg/day metformin for 6 months (average weight loss of −6.81 (−7.51 to −6.10) kg) [4]. A retrospective study that included ten adolescents with PCOS <18 years found that among the entire cohort, those treated with metformin (850 mg/day) had a 12% prevalence of obesity, compared to 50% of non-treated PCOS and 27% of individuals treated with COCP, although due to the nature of the study design, these should be interpreted with caution [42].…”

Section: Metforminmentioning

confidence: 99%

Weight Management in Adolescents with Polycystic Ovary Syndrome

Waldrop

Cree-Green

2021

Curr Obes Rep

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Purpose of Review Polycystic ovary syndrome (PCOS) is a common condition that clinically presents during adolescence. PCOS is associated with increased rates of overweight and obesity, as well as higher rates of metabolic disease, especially type 2 diabetes. Weight loss decreases PCOS symptoms and risk for metabolic disease. The goal of this review is to evaluate recent studies describing the hormonal, metabolic, and weight effects of different weight loss strategies: dietary, physical activity, pharmacotherapy, bariatric surgery, mood modification, and sleep. Recent Findings Calorie restriction continues to be supported as the primary nutrition intervention to achieve weight loss in individuals with PCOS, and a dietary macronutrient composition with lower compared to higher glycemic carbohydrates may be more effective. There is limited data that vitamins, nutraceuticals, and probiotics may improve hormonal and metabolic outcomes. Most types of physical activity are effective in improving outcomes in PCOS and lowering weight. Whereas there are promising data on anti-obesity medications such as glucagon-like peptide-1 receptor agonists in adults with PCOS and adolescents with obesity, further work is needed to know if these therapies are effective in youth with PCOS. Research is lacking on the effectiveness of other anti-obesity medications in PCOS. Bariatric surgery is especially promising for decreasing weight in adults and youth, and reversing type 2 diabetes in youth, though PCOS data are lacking. Treatment of depression in adolescents with insulin resistance and women with PCOS is associated with improved weight loss. Adolescents with PCOS and obesity may have greater sleep-related risks including circadian misalignment and obstructive sleep apnea, interventions for which have not yet been conducted. Summary Clinical trials on weight loss strategies in adolescents with PCOS remain limited, with most information inferred from studies in women with PCOS or adolescents with obesity. However, there are multiple options to optimize weight loss in dietary, activity, pharmacotherapy, bariatric surgery, mood modification, and sleep domains.

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Section: Metforminmentioning

confidence: 99%

Weight Management in Adolescents with Polycystic Ovary Syndrome

Waldrop

Cree-Green

2021

Curr Obes Rep

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“…Some results showed that COC therapy in patients with PCOS had a negative influence on carbohydrate metabolism. HOMA-IR increased which suggests increased insulin resistance [28], [29].…”

Section: Negative Influence Of the Cocs On Carbohydrate Metabolism In...mentioning

confidence: 99%

The influence of combined oral contraceptive pills on carbohydrate metabolism in healthy women and in women with PCOS - a systemic review

Wicha

Wierciszewki

Hawryluk

et al. 2022

J Educ Health Sport

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Introduction: Combined oral contraceptives (COCs) are a commonly used contraceptive method. They are used as one of the method therapy in women with PCOS. Outcomes from previous studies about the influence of the COCs on carbohydrate metabolism are diverse. Purpose: To assess the influence of combined oral contraceptives on parameters of carbohydrate metabolism in healthy women and in women with PCOS. Review methods: We conducted a systemic review according to PRISMA protocol. Databases as Pubmed, Scopus, Web of Science were screened systematically.The inclusion criteria were:a study published in 2016-2021, which contains information about the change of carbohydrate parameters as: fasting insulin, fasting glucose levels;HOMA-IR;insulin, glucose levels etc.The participants were healthy/PCOS women. Studies conducted on animals were excluded. The final number of studies enrolled in this study is 15. Abbreviated description of the state of knowledge: There are studies in which negative influences of the COCs on carbohydrate metabolism are proved. Nevertheless, many of these studies were conducted years ago.COCs, when they were introduced in 1960s, contained different compounds and amounts of hormones. Over the years a successive decrease in estrogen dose has occurred . Also progestogens have been developed in order to minimize the androgenic effects.Results of studies conducted nowadays are ambiguous. Summary: A significant impairment of carbohydrate metabolism in short period of time was not detected in healthy women. In women with PCOS the results depended on the type of COCs used.

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“…As PCOS is of complex pathological physiology, obscure etiology, and varied clinical manifestations, PCOS diagnosis remains challenging in clinical endocrinology [ 5 ]. Regardless of achievements made in PCOS treatment, most PCOS patients still need life-long treatment [ 6 ]. Therefore, the molecular mechanism of PCOS pathogenesis should be studied in depth for the development of novel diagnostic and therapeutic methods for PCOS.…”

Section: Introductionmentioning

confidence: 99%

LINC00173 regulates polycystic ovarian syndrome progression by promoting apoptosis and repressing proliferation in ovarian granulosa cells via the microRNA-124-3p (miR-124-3p)/jagged canonical Notch ligand 1 (JAG1) pathway

Chen

Kong

2022

Bioengineered

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As an endocrine and metabolic disorder, polycystic ovarian syndrome (PCOS) is common in females at childbearing age. Our work was intended to uncover the underlying role of LINC00173 and its potential regulatory mechanism in PCOS based on two cell lines (PCOS granulosa cells and KGN cells) and an in vivo model established from Sprague Dawley rats. It was revealed that LINC00173 and JAG1 expressions were upregulated, while miR-124-3p was poorly expressed in PCOS patients and PCOS rats. Functional assays showed that LINC00173 overexpression repressed proliferation and stimulated apoptosis in granulosa cells and KGN cells, while LINC00173 downregulation exhibited the opposite effects. Besides, it was verified that LINC00173 upregulated JAG1 expression in KGN cells via competitively binding to miR-124-3p. Similarly, miR-124-3p abundance was inversely related to LINC00173 and JAG1 level in PCOS. Subsequently, rescue assays elucidated that miR-124-3p upregulation or downregulation eliminated the effects on KGN cell proliferation and apoptosis mediated by LINC00173 overexpression or knockdown. In addition, it was found that the JAG1 level in KGN cells was adversely modulated by miR-124-3p and positively modulated by LINC00173. Moreover, it was further demonstrated that the reduced cell vitality and increased apoptosis of KGN cells induced by overexpressing LINC00173 could be relieved by JAG1 deletion. These findings suggested that LINC00173 could be a latent regulating factor for PCOS progression via modulating the miR-124-3p/JAG1 cascade.

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Metabolic impact of current therapeutic strategies in Polycystic Ovary Syndrome: a preliminary study

Cited by 16 publications

References 49 publications

Weight Management in Adolescents with Polycystic Ovary Syndrome

Weight Management in Adolescents with Polycystic Ovary Syndrome

The influence of combined oral contraceptive pills on carbohydrate metabolism in healthy women and in women with PCOS - a systemic review

LINC00173 regulates polycystic ovarian syndrome progression by promoting apoptosis and repressing proliferation in ovarian granulosa cells via the microRNA-124-3p (miR-124-3p)/jagged canonical Notch ligand 1 (JAG1) pathway

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