Metabolic gray matter changes of adolescents with anorexia nervosa in combined MR proton and phosphorus spectroscopy

Blasel, Stella; Pilatus, Ulrich; Magerkurth, Jörg; Stauffenberg, Maya von; Vronski, Dmitri; Mueller, Manuel; Woeckel, L.; Hattingen, Elke

doi:10.1007/s00234-011-1001-9

Cited by 28 publications

(37 citation statements)

References 90 publications

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“…Nonetheless, it is tempting to speculate that AN could result in changes in the size of neurons, glia or in metabolic processes (19). Indeed, neurohistological evidence exists suggestive of AN-related alterations in dendritic spine morphology and density (78,79) and a recent MR spectroscopy study found increased concentrations of potentially excitotoxic metabolites (glutamate) selectively in gray matter (80).…”

Section: Discussionmentioning

confidence: 98%

Global Cortical Thinning in Acute Anorexia Nervosa Normalizes Following Long-Term Weight Restoration

King¹,

Geisler²,

Ritschel³

et al. 2015

Biological Psychiatry

140

143

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Section: Discussionmentioning

confidence: 98%

Global Cortical Thinning in Acute Anorexia Nervosa Normalizes Following Long-Term Weight Restoration

King¹,

Geisler²,

Ritschel³

et al. 2015

Biological Psychiatry

140

143

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“…Malnutrition in AN is associated with changes in brain structure (e.g., reduction in gray matter, altered white matter integrity) and profound metabolic, electrolyte, and endocrine disturbances. [106][107][108][109][110] Studies in animals suggest that diet and weight can influence DA 111, 112 and 5-HT metabolism. 61 Strategies to avoid the confounding effects of abnormal nutritional status include: 1) characterizing behavioral traits that occur in childhood, prior to the onset of an ED, and 2) studying recovered anorexics, although it remains conjectural whether abnormal findings reflect traits or scars.…”

Section: State and Trait In Anmentioning

confidence: 99%

Nothing Tastes as Good as Skinny Feels: the Neurobiology of Anorexia Nervosa

Kaye¹,

Wierenga²,

Bailer³

et al. 2014

FOC

123

176

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Individuals with anorexia nervosa (AN) engage in relentless, restrictive eating and often become severely emaciated. Because there are no proven treatments, AN has high rates of relapse, chronicity, and death. Those with AN tend to have childhood temperament and personality traits, such as anxiety, obsessions, and perfectionism, which may reflect neurobiological risk factors for developing AN. Restricted eating may be a means of reducing negative mood caused by skewed interactions between serotonin aversive or inhibitory and dopamine reward systems. Brain imaging studies suggest altered eating is a consequence of dysregulated reward, and/or awareness of homeostatic needs, perhaps related to enhanced executive ability to inhibit incentive motivational drives. Understanding the neurobiology of this disorder is likely to be important for developing more effective treatments.

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“…10 The relative amount of gray matter, white matter, and cerebrospinal fluid contributing to the individual voxel was calculated using MATLAB scripts. 31 P and 1 H magnetic resonance spectra from a patient with left middle cerebral artery (MCA) stroke.…”

Section: Data Processingmentioning

confidence: 99%

Changes of pH and Energy State in Subacute Human Ischemia Assessed by Multinuclear Magnetic Resonance Spectroscopy

Zöllner

Hattingen

Singer

et al. 2015

Stroke

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Background and Purpose— In vivo changes in tissue pH and energy metabolism are key to understanding stroke pathophysiology. Our goal was to study pH changes in subacute ischemic stroke and their relation to energy metabolism, which, unlike acidosis in acute stroke, are not yet well understood. Methods— We measured tissue pH and phospholipid as well as cell energy markers, including creatine, phosphocreatine, and N -acetyl-aspartate in subacute stroke with combined 1 H and 31 P magnetic resonance spectroscopy. We included 19 patients with first-ever ischemic stroke (mean time after stroke, 6 days). We then compared metabolite concentrations in the ischemic tissue to contralateral (healthy) tissue using multivariate ANOVA to assess significant differences in metabolite levels between both tissue compartments. Results— In subacute stroke, a tissue fraction with significantly increased tissue pH was observed as compared with healthy contralateral tissue (pH, 7.09 versus 7.03; P =0.002) concurrent with splitting of the pH signal with 1 peak being more alkalotic. Furthermore, only a moderate decrease of energy-rich metabolites (phosphocreatine reduced by 17%, ATP reduced by 19%) was present, whereas total creatine was reduced by 51%. Conclusions— The finding of an alkalotic pH split in subacute ischemia is unprecedented. The pH split and only incomplete energy loss in subacute stroke suggest 2 differently viable cellular moieties, best explained by active compensatory mechanisms after acute cerebral ischemia.

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Metabolic gray matter changes of adolescents with anorexia nervosa in combined MR proton and phosphorus spectroscopy

Cited by 28 publications

References 90 publications

Global Cortical Thinning in Acute Anorexia Nervosa Normalizes Following Long-Term Weight Restoration

Global Cortical Thinning in Acute Anorexia Nervosa Normalizes Following Long-Term Weight Restoration

Nothing Tastes as Good as Skinny Feels: the Neurobiology of Anorexia Nervosa

Changes of pH and Energy State in Subacute Human Ischemia Assessed by Multinuclear Magnetic Resonance Spectroscopy

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