Metabolic Fluxes in the Renal Cortex Are Dysregulated In Vivo in Response to High-Fat Diet
Clinton M. Hasenour,
Deveena R. Banerjee,
Jamey D. Young
Abstract:Diabetes and obesity are risk factors for kidney disease. While renal glucose production increases in diabetes, recent data suggest that gluconeogenic and oxidative capacity decline in kidney disease. Thus, metabolic dysregulation caused by diet-induced insulin resistance may sensitize the kidney for a loss in function. Here we examined how diet-induced insulin resistance disrupts mitochondrial metabolic fluxes in the renal cortex in vivo. C57Bl/6J mice were rendered insulin resistant through high-fat (HF) fee… Show more
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