Metabolic fate of ochratoxin A as a coffee contaminant in a dynamic simulator of the human colon

Ouethrani, Minale; Wiele, Tom Van de; Verbeke, Ellen; Bruneau, Aurélia; Carvalho, Maryline; Rabot, Sylvie; Camel, Valérie

doi:10.1016/j.foodchem.2013.05.157

Cited by 23 publications

(15 citation statements)

References 35 publications

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“…This would indicate that OTA is able to affect the composition and/or metabolism of the colonic microbiota. Moreover, and in support of this, the work of Ouethrani et al. revealed that OTA eliminated a strain of Lactobacillus reuteri from the descending colon microbiota, which was permanent.…”

Section: Mycotoxins and The Gastrointestinal Tractmentioning

confidence: 71%

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Mycotoxins and the intestine

Broom¹

2015

Animal Nutrition

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Fungal biochemical pathways can yield various compounds that are not considered to be necessary for their growth and are thus referred to as secondary metabolites. These compounds have been found to have wide ranging biological effects and include potent poisons (mycotoxins). Mycotoxins invariably contaminate crops and (thus) animal feeds. The intestine is the key link between ingested mycotoxins and their detrimental effects on the animal. Effects on the intestine, or intestinal environment, and immune system have been reported with various mycotoxins. These effects are almost certainly occurring across species. Most, if not all, of the reported effects of mycotoxins are negative in terms of intestinal health, for example, decreased intestinal cell viability, reductions in short chain fatty acid (SCFA) concentrations and elimination of beneficial bacteria, increased expression of genes involved in promoting inflammation and counteracting oxidative stress. This challenge to intestinal health will predispose the animal to intestinal (and systemic) infections and impair efficient digestion and absorption of nutrients, with the associated effect on animal productivity.

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Section: Mycotoxins and The Gastrointestinal Tractmentioning

confidence: 71%

“…It goes without saying that microbial cells can be susceptible to mycotoxins. Recent work by Ouethrani et al. (2013) demonstrated that ochratoxin A (OTA) significantly reduced acetic, butyric and total short chain fatty acid (SCFA) concentrations in a dynamic simulation model of the descending human colon.…”

Section: Mycotoxins and The Gastrointestinal Tractmentioning

confidence: 99%

Mycotoxins and the intestine

Broom¹

2015

Animal Nutrition

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“…Indeed, in addition to the important roles in maintaining gastrointestinal tract homeostasis, intestinal microbiota also affects multitudinous physiological functions of other visceral organs (e.g., brain, liver, and lung) and is involved in mediating the pathogenesis of different diseases in these organs [37–42]. Although previous investigations have demonstrated that OTA reduces the relative abundance of beneficial microbes (e.g., Lactobacillus and Bifidobacteria ) [43], shapes the diversity of the intestinal microbiota, and increases the fecal total facultative anaerobes in rats [44], whether OTA-induced injuries in extraintestinal organs (e.g., liver and kidney) through intestinal microbiota remains to be revealed.…”

Section: Discussionmentioning

confidence: 99%

Ochratoxin A induces liver inflammation: involvement of intestinal microbiota

et al. 2019

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BackgroundOchratoxin A (OTA) is a widespread mycotoxin and induces liver inflammation to human and various species of animals. The intestinal microbiota has critical importance in liver inflammation; however, it remains to know whether intestinal microbiota mediates the liver inflammation induced by OTA. Here, we treated ducklings with oral gavage of OTA (235 μg/kg body weight) for 2 weeks. Then, the microbiota in the cecum and liver were analyzed with 16S rRNA sequencing, and the inflammation in the liver was analyzed. To explore the role of intestinal microbiota in OTA-induced liver inflammation, intestinal microbiota was cleared with antibiotics and fecal microbiota transplantation was conducted.ResultsHere, we find that OTA treatment in ducks altered the intestinal microbiota composition and structure [e.g., increasing the relative abundance of lipopolysaccharides (LPS)-producing Bacteroides], and induced the accumulation of LPS and inflammation in the liver. Intriguingly, in antibiotic-treated ducks, OTA failed to induce these alterations in the liver. Notably, with the fecal microbiota transplantation (FMT) program, in which ducks were colonized with intestinal microbiota from control or OTA-treated ducks, we elucidated the involvement of intestinal microbiota, especially Bacteroides, in liver inflammation induced by OTA.ConclusionsThese results highlight the role of gut microbiota in OTA-induced liver inflammation and open a new window for novel preventative or therapeutic intervention for mycotoxicosis.

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“…A study investigating the effect of OTA on gut microbiota using bioreactors has been carried out by Ouethrani et al ( 2013 ), in which each bioreactor represents different parts of the adult human gut (Ouethrani et al, 2013 ). Based on the study, the gut microbiota degradation of OTA and microbiota diversity alteration were observed only at the descending colon after 1-week exposure to OTA.…”

Section: Gut Microbiotamentioning

confidence: 99%

Mycotoxin: Its Impact on Gut Health and Microbiota

Liew

Sabran

2018

Front. Cell. Infect. Microbiol.

316

195

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The secondary metabolites produced by fungi known as mycotoxins, are capable of causing mycotoxicosis (diseases and death) in human and animals. Contamination of feedstuffs as well as food commodities by fungi occurs frequently in a natural manner and is accompanied by the presence of mycotoxins. The occurrence of mycotoxins' contamination is further stimulated by the on-going global warming as reflected in some findings. This review comprehensively discussed the role of mycotoxins (trichothecenes, zearalenone, fumonisins, ochratoxins, and aflatoxins) toward gut health and gut microbiota. Certainly, mycotoxins cause perturbation in the gut, particularly in the intestinal epithelial. Recent insights have generated an entirely new perspective where there is a bi-directional relationship exists between mycotoxins and gut microbiota, thus suggesting that our gut microbiota might be involved in the development of mycotoxicosis. The bacteria–xenobiotic interplay for the host is highlighted in this review article. It is now well established that a healthy gut microbiota is largely responsible for the overall health of the host. Findings revealed that the gut microbiota is capable of eliminating mycotoxin from the host naturally, provided that the host is healthy with a balance gut microbiota. Moreover, mycotoxins have been demonstrated for modulation of gut microbiota composition, and such alteration in gut microbiota can be observed up to species level in some of the studies. Most, if not all, of the reported effects of mycotoxins, are negative in terms of intestinal health, where beneficial bacteria are eliminated accompanied by an increase of the gut pathogen. The interactions between gut microbiota and mycotoxins have a significant role in the development of mycotoxicosis, particularly hepatocellular carcinoma. Such knowledge potentially drives the development of novel and innovative strategies for the prevention and therapy of mycotoxin contamination and mycotoxicosis.

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Metabolic fate of ochratoxin A as a coffee contaminant in a dynamic simulator of the human colon

Cited by 23 publications

References 35 publications

Mycotoxins and the intestine

Mycotoxins and the intestine

Ochratoxin A induces liver inflammation: involvement of intestinal microbiota

Mycotoxin: Its Impact on Gut Health and Microbiota

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