Metabolic factors influencing lower urinary tract function

Obstructive response of human bladder to BPH vs. rabbit bladder response to partial outlet obstruction: A direct comparison

“…The cellular mechanism responsible for decreased oxidative metabolism involves decreased mitochondrial enzyme activity, as was evidenced by specific decreases in the activities of citrate synthase (CS), malate dehydrogenase, and cytochrome oxidase Lin et al, 1992;Hsu et al, 1994]. Further studies showed that there was no decline in the activities of several cytosolic enzymes including creatine kinase, hexokinase, myosin ATPase, and phosphoribosyl transferase [reviewed in Levin et al, 1999a].…”

“…13) [Levin et al, 1999aNigro et al, 1999. Thus, the decrease in oxidative metabolism is a function of decreased mitochondrial oxidation of substrates.…”

Modelized analysis of pressure‐flow studies of patients with lower urinary tract symptoms due to benign prostatic enlargement

“…Therefore, we assumed that detrusor hypertrophy leads to an increase in detrusor contractile force. On the other hand, pressures lower than predicted by the standard model can be accounted for by a weakly contracting detrusor, possibly from metabolic detrusor dysfunction [Rohrman et al, 1996;Levin et al, 1999]. In our model, we accounted for these two phenomena by multiplying the standard detrusor force by a''detrusor force coe⁄cient'' k.…”

Calcium Effects on Superoxide Dismutase and Catalase of the Rabbit Urinary Bladder Muscle and Mucosa

“…Another major difference relates to mitochondrial function and metabolism. Bladder mucosa has a significantly higher blood flow than the muscle, significantly higher metabolic rates and mitochondrial function than muscle, and higher anaerobic metabolism than muscle [52][53][54][55][56] . The differences in muscle and mucosal blood flow and metabolism make the mucosa significantly more sensitive to ischemia than the muscle.…”