Hepatitis C - From Infection to Cure 2018
DOI: 10.5772/intechopen.77387
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Metabolic Factors and Their Influence on the Clinical Course and Response to HCV Treatment

Abstract: Nowadays, direct-acting antivirals (DAA) have been used for hepatitis C virus (HCV) treatment leading to cure in 90-95% of non-cirrhotic patients depending on genotype, treatment experience, and regimen used. It was observed rates of antiviral response above 90% in compensated cirrhotic patients that should be treated for long time and/or ribavirin may be required. Metabolic syndrome, obesity, and insulin resistance are increasing worldwide and further contribute to hepatic steatosis and have long been recogni… Show more

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Cited by 1 publication
(4 citation statements)
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“…Although DAAs have negated the presence of steatosis on SVR in those with HCV monoinfection [30], less is known about those with HIV-HCV coinfection. In this cohort, the SVR-12 rate was high, similar to that found in studies on participants with HCV monoinfection (90%-95%) [27,29], and not impacted by the presence of hepatic steatosis.…”
Section: Discussionsupporting
confidence: 85%
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“…Although DAAs have negated the presence of steatosis on SVR in those with HCV monoinfection [30], less is known about those with HIV-HCV coinfection. In this cohort, the SVR-12 rate was high, similar to that found in studies on participants with HCV monoinfection (90%-95%) [27,29], and not impacted by the presence of hepatic steatosis.…”
Section: Discussionsupporting
confidence: 85%
“…In the interferon era, hepatic steatosis negatively impacted SVR [25,26]. The development of DAAs has dramatically increased the ability to achieve SVR in chronic HCV [27][28][29][30]. Although DAAs have negated the presence of steatosis on SVR in those with HCV monoinfection [30], less is known about those with HIV-HCV coinfection.…”
Section: Discussionmentioning
confidence: 99%
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