Metabolic evaluation of patients with recurrent, multiple or bilateral renal stones in Jaffna

Rajendra, S.

doi:10.4038/cmj.v65i3.9186

Cited by 3 publications

(6 citation statements)

References 17 publications

(35 reference statements)

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“…Focusing in Northern Sri Lanka, a study carried out among 104 patients with renal stones revealed that 75.9% of the patients had calcium oxalate and 13.5 % had uric acid stones [15].…”

Section: Discussionmentioning

confidence: 99%

“…Sri Lankan data on the prevalence of metabolic disorders among urolithiasis patients is largely lacking. A study done on 30 patients with recurrent stone disease in northern Sri Lanka revealed that 80% of the patients suffered from a single metabolic derangement or a combination of multiple derangements [15]. Hyperoxaluria and hypomagnesuria were the most common metabolic disorders with 30% of the patients suffering from each of the conditions.…”

Section: Discussionmentioning

confidence: 99%

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The Spectrum the Disease and Metabolic Evaluation in Urolithiasis Patients: A Prospective Study in a Tertiary Urology Centre.

Balagobi,

Thangarajah,

Thuraisamy Sarma

et al. 2024

Preprint

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Introduction Urolithiasis, a prevalent urological condition (8-13% globally) exhibits regional variations, influenced by water quality, climate, health factors and diet. Sri Lanka with its tropical climate and dietary patterns is part of the "Stone Belt" of Asia. This study in Northern Sri Lanka examines urinary stone compositions and assesses the prevalence of metabolic disorders among urolithiasis patients. Methods This prospective cross-sectional study, conducted at tertiary urology centre from July 2022 to June 2023, focused on surgically treated urolithiasis patients. Institutional ethical clearance was obtained. Patient details and investigational findings were collected through questionnaires and data extraction forms. Stone analysis utilized Fourier transform infrared spectroscopy and detailed metabolic evaluation of 24 hour urine collection sample is carried out. Results This study followed 153 surgically treated urolithiasis patients, primarily male (64.3%), mean age 48.64. Ureteric colic (48.4%) was common, with kidney stones (45.8%) prevalent; 57.52% had recurrent stones. Diabetes mellitus (DM=23.5%) was the top comorbidity. Calcium oxalate monohydrate (COM) stones (78.4%) were most frequent, followed by uric acid (12.4%). COM predominated in 40-59 age group. No significant gender-stone type association. 86.9% had metabolic abnormalities, notably hypocitraturia (60.1%). 23% had both hypocitraturia and hypomagnesuria. Some metabolic disorders showed gender differences, with a marginal age-metabolic disorders association (p < 0.061). Urine oxalate levels were normal with higher variability in males. Conclusion Middle-aged males with urolithiasis commonly presented with ureteric colic and predominantly had calcium oxalate monohydrate stones. Recurrent stones were common, often accompanied by metabolic abnormalities such as hypocitraturia and hypomagnesuria, with diabetes mellitus as the primary comorbidity.

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“…Focusing in Northern Sri Lanka, a study carried out among 104 patients with renal stones revealed that 75.9% of the patients had calcium oxalate and 13.5 % had uric acid stones [15].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Spectrum the Disease and Metabolic Evaluation in Urolithiasis Patients: A Prospective Study in a Tertiary Urology Centre.

Balagobi,

Thangarajah,

Thuraisamy Sarma

et al. 2024

Preprint

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show abstract

“…If we add low-urine pH to that, there will be an increase in uric acid ions, predisposing to the formation of uric acid stones. In addition, urinary urate reduces calcium and oxalate solubility [9 ▪ ,11]. Concerning the citrate, in normal situations it combines with calcium to form a soluble complex, reducing the formation of crystals of calcium oxalate and calcium phosphate.…”

Section: What Is Included In the Extensive Analysis?mentioning

confidence: 99%

“…Concerning the citrate, in normal situations it combines with calcium to form a soluble complex, reducing the formation of crystals of calcium oxalate and calcium phosphate. Hence, hypocitraturia reduces this inhibitory effect and increases the ionized calcium levels, making them capable of crystallizing [11,25].…”

Section: What Is Included In the Extensive Analysis?mentioning

confidence: 99%

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Metabolic evaluation: is there really a future?

Traxer

Corrales

Sierra

2022

Current Opinion in Urology

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Purpose of reviewTo confirm the need for a metabolic evaluation in stone formers based on the latest information published in the last 24 months and in the current 2022 American and European urological guidelines. Recent findingsRecent studies suggest that urolithiasis prevalence has been increasing since 1990. Along with it, metabolic abnormalities that contribute to the development of kidney stones are also increasing, such as hyperuricosuria, hyperoxaluria, hypocitraturia, hypomagnesuria, hypocalciuria, hypophosphaturia, and hyperuricemia. Those abnormalities can only be detected through a metabolic evaluation in patients with stone disease.

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Assessment of Urinary Stone Chemical Compositions and Prevalence of Metabolic Disorders Among Urolithiasis Patients in Northern Sri Lanka: A Prospective Study

Balasingam,

Varothayan,

Rajendra

et al. 2024

Cureus

Self Cite

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Introduction Urolithiasis, a common urological disorder affecting the global population, demonstrates geographical diversity due to factors such as water quality, climate variations, health conditions, and dietary habits. This study, conducted in Northern Sri Lanka, examines urinary stone compositions and assesses the prevalence of metabolic disorders among urolithiasis patients. Methods This prospective cross-sectional study, conducted at Jaffna Teaching Hospital, Jaffna, Sri Lanka, from July 2022 to June 2023, focused on surgically treated urolithiasis patients. Institutional ethical clearance was obtained. Patient details and investigational findings were collected through questionnaires and data extraction forms. Stone analysis utilized Fourier transform infrared spectroscopy, and a detailed metabolic evaluation of a 24-hour urine collection sample was carried out. Results This study followed 153 surgically treated urolithiasis patients, primarily male (64.3%), with a mean age of 48.64. Ureteric colic (48.4%) was common, with kidney stones (45.8%) prevalent; 57.52% had recurrent stones. Diabetes mellitus (DM; 23.5%) was the top comorbidity. Calcium oxalate monohydrate (COM) stones (78.4%) were the most frequent, followed by uric acid (12.4%). COM predominated in the 40-59 age group. There was no significant gender-stone type association. A total of 86.9% had metabolic abnormalities, notably hypocitraturia (60.1%). Moreover, 23% had both hypocitraturia and hypomagnesuria. Some metabolic disorders showed gender differences, with a marginal age-metabolic disorder association (p < 0.061). Urine oxalate levels were normal, with higher variability in males. Conclusion Middle-aged males with urolithiasis commonly presented with ureteric colic and predominantly had COM stones. Recurrent stones were common, often accompanied by metabolic abnormalities such as hypocitraturia and hypomagnesuria, with DM as the primary comorbidity.

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Metabolic evaluation of patients with recurrent, multiple or bilateral renal stones in Jaffna

Cited by 3 publications

References 17 publications

The Spectrum the Disease and Metabolic Evaluation in Urolithiasis Patients: A Prospective Study in a Tertiary Urology Centre.

The Spectrum the Disease and Metabolic Evaluation in Urolithiasis Patients: A Prospective Study in a Tertiary Urology Centre.

Metabolic evaluation: is there really a future?

Assessment of Urinary Stone Chemical Compositions and Prevalence of Metabolic Disorders Among Urolithiasis Patients in Northern Sri Lanka: A Prospective Study

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