Metabolic Epilepsy

Reddy, Chaithanya; Saini, Arushi Gahlot

doi:10.1007/s12098-020-03510-w

Cited by 18 publications

(14 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The above-mentioned conditions are a cause of secondary epilepsy, but in addition, the study also confirmed reduced brain volumes in cases of sudden unexpected death due to epilepsy. Seizures may also be a consequence of acquired metabolic disorders, such as hypoglycemia, hyponatremia, renal failure or hypoparathyroidism [ 22 ], but our patients had no relevant information on such disorders. In one study, researchers identified and quantified 72 metabolites, 14 of which (especially monophosphate and O-acetylcholine) showed significant differences in concentrations between the patients with not-otherwise-specified epilepsy and healthy controls [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Epilepsy in Pediatric Patients—Evaluation of Brain Structures’ Volume Using VolBrain Software

Woźniak

Zbroja

Matuszek

et al. 2022

JCM

View full text Add to dashboard Cite

Epilepsy is one of the most frequent serious brain disorders. Approximately 30,000 of the 150,000 children and adolescents who experience unprovoked seizures are diagnosed with epilepsy each year. Magnetic resonance imaging is the method of choice in diagnosing and monitoring patients with this condition. However, one very effective tool using MR images is volBrain software, which automatically generates information about the volume of brain structures. A total of 57 consecutive patients (study group) suffering from epilepsy and 34 healthy patients (control group) who underwent MR examination qualified for the study. Images were then evaluated by volBrain. Results showed atrophy of the brain and particular structures—GM, cerebrum, cerebellum, brainstem, putamen, thalamus, hippocampus and nucleus accumbens volume. Moreover, the statistically significant difference in the volume between the study and the control group was found for brain, lateral ventricle and putamen. A volumetric analysis of the CNS in children with epilepsy confirms a decrease in the volume of brain tissue. A volumetric assessment of brain structures based on MR data has the potential to be a useful diagnostic tool in children with epilepsy and can be implemented in clinical work; however, further studies are necessary to enhance the effectiveness of this software.

show abstract

Section: Discussionmentioning

confidence: 99%

Epilepsy in Pediatric Patients—Evaluation of Brain Structures’ Volume Using VolBrain Software

Woźniak

Zbroja

Matuszek

et al. 2022

JCM

View full text Add to dashboard Cite

show abstract

“…[ 2 ] It is important to remember biotinidase deficiency as an important differential diagnosis of recurrent seizures in infants, especially when associated with skin manifestations as it is a treatable inborn error of metabolism and the diagnosis can easily be established by a simple enzyme assay. [ 3 ]…”

Section: Discussionmentioning

confidence: 99%

Electroclinical Response to a Vitamin

Saini

Bhagwat

Paria

et al. 2022

Annals of Indian Academy of Neurology

View full text Add to dashboard Cite

“…In the present study, the etiology of epilepsy was divided into clear etiology (including structural, genetic, and infectious etiology) and unknown etiology. There were no patients with metabolic etiology or immune etiology due to the low incidence of metabolic epilepsy, the lack of genetic examination, and the poor prognosis of autoimmune-associated epilepsy ( 20 , 21 ). The duration of epilepsy before treatment was defined as the time from seizure onset to registration at outpatient clinics.…”

Section: Methodsmentioning

confidence: 99%

Comparison of Long-Term Outcomes of Monotherapy and Polytherapy in Seizure-Free Patients With Epilepsy Following Antiseizure Medication Withdrawal

Wang

et al. 2021

Front. Neurol.

View full text Add to dashboard Cite

Objective: The objectives of this study were to compare the risk and timing of seizure relapse in seizure-free patients with epilepsy following the withdrawal of monotherapy or polytherapy and to identify relevant influencing factors.Methods: Patients who had achieved at least a 2-year seizure remission and started the withdrawal of antiseizure medication (ASM) were enrolled in this study. All patients were followed for at least 3 years or until seizure relapse. According to the number of ASMs at the time of withdrawalwas about twice than that, patients were divided into two groups: monotherapy group and polytherapy group. The Cox proportional hazards model was used to compare the recurrence risk of the two groups. Univariate analysis and multiple logistic regression analysis were used to analyze potential confounding variables between patients treated with monotherapy and polytherapy.Results: A total of 188 patients (119 males and 69 females) were included. The average prescribed daily dose of most ASMs at the time of withdrawal was moderate or low (30–50% defined daily dose). The recurrence of most patients (89.2%) occurred within the first 3 years after withdrawal. The recurrence risk in patients treated with polytherapy at the time of withdrawal was about twice than that of the monotherapy group [p = 0.001, hazard ratio (HR) = 2.152, 95% confidence interval (CI) = 1.350–3.428]. Multivariate analysis showed that patients treated with polytherapy were significantly older at seizure onset [p = 0.024, odd ratio (OR) = 1.027, 95% CI = 1.004–1.052] and had a significantly longer duration of epilepsy before treatment (p = 0.004, OR = 1.009, 95% CI = 1.003–1.015) compared to patients in the monotherapy group. In addition, a history of perinatal injury was found to be an independent risk factor of seizure relapse in patients with ASM withdrawal.Conclusion: The average prescribed daily dose of most ASMs at the time of withdrawal was moderate or low. Patients who received polytherapy at the time of withdrawal, particularly those with later seizure onset age and longer epilepsy duration before treatment, had a higher recurrence risk after ASMs withdrawal compared to patients treated with monotherapy.

show abstract

Metabolic Epilepsy

Cited by 18 publications

References 27 publications

Epilepsy in Pediatric Patients—Evaluation of Brain Structures’ Volume Using VolBrain Software

Epilepsy in Pediatric Patients—Evaluation of Brain Structures’ Volume Using VolBrain Software

Electroclinical Response to a Vitamin

Comparison of Long-Term Outcomes of Monotherapy and Polytherapy in Seizure-Free Patients With Epilepsy Following Antiseizure Medication Withdrawal

Contact Info

Product

Resources

About