Metabolic effects of vanadyl sulfate in humans with non—insulin-dependent diabetes mellitus: In vivo and in vitro studies

Goldfine, Allison B.; Patti, Mary‐Elizabeth; Zuberi, Lubna; Goldstein, Barry J.; LeBlanc, Raeann; Landaker, Edwin J.; Jiang, Zhen; Willsky, Gail R.; Kahn, C. Ronald

doi:10.1016/s0026-0495(00)90418-9

Cited by 160 publications

(137 citation statements)

References 62 publications

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“…[8][9][10][11][12][13][14] Interestingly, both compounds have been proposed to partially improve human DM. [15][16][17][18][19][20][21][22][23][24] However, the vanadyl ion is less toxic than the vanadate ion, as judged by the LD 50 values in several animals, 25,26) , and most vanadium in normal rats treated with vanadate exists in the vanadyl form. 7,27) Based on these findings, vanadyl(IV) complexes with low molecular weight organic ligands have recently been prepared to provide more effective insulin-mimetic compounds than vanadyl sulfate (VOSO 4 ).…”

mentioning

confidence: 99%

Insulin-Mimetic Vanadyl(IV) Complexes as Evaluated by Both Glucose-Uptake and Inhibition of Free Fatty Acids (FFA)-Release in Isolated Rat Adipocytes

Adachi

Sakurai

2004

CHEMICAL & PHARMACEUTICAL BULLETIN

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We have recently proposed the existence of some potent vanadyl complexes with blood glucose-lowering activity in experimental diabetic animals based on the results of an in vitro FFA (free fatty acids)-release assay in isolated rat adipocytes treated with epinephrine and evidence of an in vivo blood glucose lowering effect in experimental diabetic animals. However, the FFA assay depends indirectly on the glucose-uptake of vanadyl complexes in adipocytes. It is therefore necessary to develop a more reliable in vitro glucose-uptake assay, in place of the glucose uptake method using radioactive compounds such as 14 C-glucose, to identify insulin-mimetic vanadyl complexes. In the present study, we proposed a combined in vitro assay by using the conventional glucose oxidase method for glucose-uptake and FFA assay in isolated rat adipocytes. Insulin, vanadyl sulfate (VOSO 4 ), bis(picolinato)vanadyl (VO(pa) 2 ), and bis(6-methylpicolinato)vanadyl (VO(6mpa) 2 ) complexes exhibited concentration-dependent uptake of (؉)-D-glucose and inhibition of FFA release in the adipocytes treated with epinephrine. Vanadyl complexes were found to accelerate glucose-uptake at lower concentrations than VOSO 4 . In vitro high insulin-mimetic activity of VO(pa) 2 and VO(6mpa) 2 were thus indicated by both glucose-uptake and FFA-release, with the insulin-mimetic activity of VO(6mpa) 2 being higher than that of VO(pa) 2 , as suggested by the partition coefficient (0.330 for VO(pa) 2 and 0.595 for VO(6mpa) 2 ). The proposed assay provides a more reliable method than each single method for the evaluation of in vitro insulin-mimetic activity of compounds.Key words vanadyl compound; glucose-uptake assay; free fatty acids (FFA)-release assay; insulin-mimetic effect; adipocyte 428

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confidence: 99%

Insulin-Mimetic Vanadyl(IV) Complexes as Evaluated by Both Glucose-Uptake and Inhibition of Free Fatty Acids (FFA)-Release in Isolated Rat Adipocytes

Adachi

Sakurai

2004

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…The mechanism supporting vanadium supplementation is likely linked to its ability to promote increased insulin-mediated glucose disposal. Like chromium, vanadium efficacy appears to also depend on the degree of diabetic complications, with T2DM patients (N. Cohen et al, 1995;Cusi et al, 2001;Goldfine et al, 2000;Halberstam et al, 1996) reporting greater efficacy compared to non-diabetics (Halberstam et al, 1996;JacquesCamarena et al, 2008;Jentjens & Jeukendrup, 2002).…”

Section: Magnesium Chromium Vanadiummentioning

confidence: 99%

Minimizing Postprandial Oxidative Stress in Type 2 Diabetes: The Role of Exercise and Selected Nutrients

McCarthy¹,

Farney²

2011

Role of the Adipocyte in Development of Type 2 Diabetes

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“…These complexes are potentially useful as orally available treatments for diabetes mellitus and are used as catalysts in various oxidation reactions [1][2][3][4][5][6][7][8][9]. Structural characterization of the bimetallic oxovanadium complexes should be a key to the further development of their functions.…”

Section: Introductionmentioning

confidence: 99%

ESI–IT–MS n and DFT calculation for electron affinities of bimetallic oxovanadium complexes

Liao

Wang

et al. 2011

Monatsh Chem

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Metabolic effects of vanadyl sulfate in humans with non—insulin-dependent diabetes mellitus: In vivo and in vitro studies

Cited by 160 publications

References 62 publications

Insulin-Mimetic Vanadyl(IV) Complexes as Evaluated by Both Glucose-Uptake and Inhibition of Free Fatty Acids (FFA)-Release in Isolated Rat Adipocytes

Insulin-Mimetic Vanadyl(IV) Complexes as Evaluated by Both Glucose-Uptake and Inhibition of Free Fatty Acids (FFA)-Release in Isolated Rat Adipocytes

Minimizing Postprandial Oxidative Stress in Type 2 Diabetes: The Role of Exercise and Selected Nutrients

ESI–IT–MS n and DFT calculation for electron affinities of bimetallic oxovanadium complexes

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