Metabolic effects of obesity causing disease in childhood

Abrams, Pamela; Katz, Lorraine E. Levitt

doi:10.1097/med.0b013e3283424b37

Cited by 73 publications

(58 citation statements)

References 43 publications

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“…Childhood overweight is associated with serious consequences for health and well-being both during childhood years and in adulthood (3)(4)(5)(6)(7). Effective early preventive strategies are therefore urgently needed.…”

Section: Introductionmentioning

confidence: 99%

Late pregnancy reversal from excessive gestational weight gain lowers risk of childhood overweight-A cohort study

Kries

Chmitorz

Rasmussen

et al. 2013

Obesity

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Objective: Whether reversal to adequate gestational weight gain (GWG) in the third trimester reverses the risk for childhood overweight associated with excessive GWG is assessed. Design and Methods: In a retrospective cohort study in 6,665 mother-child pairs, pre-pregnancy weight and the temporal course of GWG were collected from medical records. Overweight as defined by International Obesity Task Force was assessed at a mean age of 5.8 years. Main exposures were exceeding week-specific cut-off values for GWG in the third trimester or any previous trimester. Logistic regression models, adjusted for possible confounding factors, were used to predict the risk of childhood overweight from excessive GWG in the third trimester with stratification by excessive GWG in previous trimesters. Results: In the final model, women who avoided excessive GWG in the third trimester had children with a 31% (odds ratio [OR]: 0.69, 95% confidence interval [CI]: 0.59, 0.82) lower probability being overweight. A similar association was observed for reversing from excessive GWG in the first or second trimester to normal GWG in the third trimester: 27% (OR: 0.73, 95% CI: 0.53, 0.99). Conclusions: Avoidance of excessive GWG in the third trimester is associated with lower risk of childhood overweight even in case of excessive GWG in the first or second trimester.

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Section: Introductionmentioning

confidence: 99%

Late pregnancy reversal from excessive gestational weight gain lowers risk of childhood overweight-A cohort study

Kries

Chmitorz

Rasmussen

et al. 2013

Obesity

View full text Add to dashboard Cite

show abstract

“…Also, in pediatric autopsies of overweight and obese children between the ages of 2-19 years, Schwimmer et al (Abrams & Levitt Katz, 2011) found non-alcoholic fatty livers in the majority of cases. Twenty-three percent of those cases had progressed to steatohepatitis, which can develop into fibrosis and cirrhosis of the liver.…”

Section: Gastrointestinalmentioning

confidence: 99%

“…Increased Gastrointestinal (GI) disturbances such as constipation, gastroesophageal reflux (Philippi-Hohne, 2010), Irritable Bowel Syndrome, and abdominal pain (Abrams & Levitt Katz, 2011) have been found in obese children. Also, in pediatric autopsies of overweight and obese children between the ages of 2-19 years, Schwimmer et al (Abrams & Levitt Katz, 2011) found non-alcoholic fatty livers in the majority of cases.…”

Section: Gastrointestinalmentioning

confidence: 99%

“…With the exception of adeno-tonsillar involvement, significantly more obstructive apnea/hypopnea events per hour of sleep have been found in obese children (Abrams & Levitt Katz, 2011). This chronic nocturnal hypoxemia can lead to pulmonary hypertension (Philippi-Hohne, 2010), which is a precursor to lung damage.…”

Section: Pulmonarymentioning

confidence: 99%

“…Orthopedic complications such as poor balance, pain (especially in knee joints), impaired mobility, lower extremity malignancy, and fractures requiring surgical interventions (Abrams & Levitt Katz, 2011) have all been documented in obese children.…”

Section: Musculoskeletalmentioning

confidence: 99%

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