Metabolic Effects of Intravenous Triiodothyroacetic Acid in Primary Myxedema

Triiodothyroacetic acid in health and disease

“…In general, TA 3 doses of 10-30 µg/kg/day improved the myxedematous appearance and restored several parameters that reflect tissue TH status, including plasma cholesterol levels, urinary creatine excretion, electrocardiographic abnormalities and body weight, whereas no effect on BMR was observed (Lerman & Pitt-Rivers 1955, 1956, Trotter 1955, 1956, De Graeff et al 1957, Ibbertson et al 1959, Boyd & Oliver 1960. Normalization of BMR is generally observed in a dose range of 50-75 µg/kg/day (Table 4).…”

“…Mechelany and coworkers (Mechelany et al 1991) have shown that TA 3 reduced serum creatine kinase levels. TA 3 also increased urinary creatine levels in hypothyroid subjects, suggesting an increase in glomerular filtration rate (Lerman & Pitt-Rivers 1956, Rall et al 1956, De Graeff et al 1957, Ibbertson et al 1959.…”

“…i.p., intraperitoneal; i.v., intravenous; s.c., subcutaneous; stim., TRH-stimulated. Oliver & Boyd (1957), Boyd & Oliver (1960), Medeiros-Neto et al (1980), Beck-Peccoz et al (1988), Lind et al (1989), Bracco et al (1993), Brenta et al (2003) ↓ Hypo ~10 µg/kg/day; 2-3 month Lerman & Pitt-Rivers (1955, 1956, Trotter (1955Trotter ( , 1956, Rall et al (1956), Zondek et al (1956), De Graeff et al (1957, Ibbertson et al (1959), Boyd & Oliver (1960), Hill et al (1960), Lerman (1961) Trotter (1955Trotter ( , 1956), Lerman & Pitt-Rivers (1956), Rall et al (1956), Zondek et al (1956), De Graeff et al (1957, Ibbertson et al (1959), Hill et al (1960), Boyd & Oliver (1960), Lerman (1961), Sherman et al (1997) Protein oxidation = Eu 45 µg/kg/day; 3 week Bracco et al (1993) (Continued) 234:2 and sleeping energy expenditure, presumably due to a reduction of endogenous TH production, whereas protein oxidation was unaffected (Bracco et al 1993). These parameters significantly increased in subjects treated with 2.4-4.8 µg LT 4 /kg/day (Bracco et al 1993).…”

The Metabolic Effects of the Acetic and Propionic Acid Analogs of Thyroxine and Triiodothyronine*

“…Other studies in man have suggested a dissociation of responses to those drugs (18)(19)(20)(21)(22)(23)(24)(25). In patients with hypothyroidism, (19,21) it was noted that on small doses of the acetic acid analogs the serum cholesterol level fell, the nitrogen and phosphorus balances became negative, and the patients were clinically improved without any significant change in basal metabolic rate.…”

“…In patients with hypothyroidism, (19,21) it was noted that on small doses of the acetic acid analogs the serum cholesterol level fell, the nitrogen and phosphorus balances became negative, and the patients were clinically improved without any significant change in basal metabolic rate. Other studies in euthyroid subjects have demonstrated a lowering of the serum cholesterol level, which was usually temporary, with no effect on the basal metabolic rate, following the administration of small amounts of these acetic acid analogs (18,(20)(21)(22)(24)(25)(26)(27). These findings suggested that there might be more than one thyroid hormone, that the acetic acid derivatives were primarily effective in cholesterol metabolism, or that a change in the basal metabolic rate was not an obligatory accompaniment of thyroid hormone activity.…”