Metabolic effects of <i><scp>L</scp>actobacillus reuteri</i><scp>DSM</scp> 17938 in people with type 2 diabetes: <scp>A</scp> randomized controlled trial

Mobini, Reza; Tremaroli, Valentina; Ståhlman, Marcus; Karlsson, Fredrik; Levin, Max; Ljungberg, Maria; Sohlin, Maja; Forslund, Heléne Bertéus; Perkins, Rosie; Bäckhed, Fredrik; Jansson, Per‐Anders

doi:10.1111/dom.12861

Cited by 213 publications

(199 citation statements)

References 35 publications

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“…A significant increase of deoxycholic acid concentration was found only in the group of patients with a higher insulin sensitivity index and a considerable reduction in HbA 1c . The increase in deoxycholic acid after Lactobacillus reuteri supplementation showed a positive correlation with the improvement of insulin sensitivity index …”

Section: The Role Of Gut Microbiome In Obesity and Diabetesmentioning

confidence: 88%

Obesity and diabetes—Not only a simple link between two epidemics

Chobot¹,

Górowska-Kowolik²,

Sokołowska

et al. 2018

Diabetes Metabolism Res

221

158

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SummaryDiabetes (DM) as well as obesity, due to their increasing incidence, were recognized as epidemic by the World Health Organization. Obesity is involved not only in the aetiopathogenesis of the most common worldwide type of DM—type 2 diabetes—but also in the development of its complications. There is also increasing scientific evidence regarding the role of obesity and overweight in type 1 diabetes. Weight gain may be considered as a complication of insulin treatment but also reveals significant pathophysiological impact on various stages of the disease. Another very important aspect related to DM as well as obesity is the microbiome, which is highly variable. The function of the gut microflora, its interaction with the whole organism, and its role in the development of obesity and type 1 diabetes as well as type 2 diabetes are still not fully understood and subject of ongoing investigations. This review presents a summary of recently published results concerning the relation of obesity/overweight and DM as well as their associations with the microbiome.

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Section: The Role Of Gut Microbiome In Obesity and Diabetesmentioning

confidence: 88%

Obesity and diabetes—Not only a simple link between two epidemics

Chobot¹,

Górowska-Kowolik²,

Sokołowska

et al. 2018

Diabetes Metabolism Res

221

158

View full text Add to dashboard Cite

show abstract

“…The genus Blautia has been associated with phenylacetylglutamine, circulating metabolite derived from bacterial protein fermentation found in early renal function decline [31]. The undesirable effects of the HFF diet was possibly attenuated by the increase in L. Reuteri and B. fragilis involved in the inhibition of the growth of pathogenic bacteria [32], insulin sensitivity [33], and intestinal epithelium integrity [34]. During the development of obesity, dysbiosis in gut microbiota increased the production of LPS mainly in the HFS group, which could activate TLR4 and promote the induction of NF-κB, provoking the expression of inflammatory cytokines and ROS production.…”

Section: Discussionmentioning

confidence: 99%

Differential Effect of Sucrose and Fructose in Combination with a High Fat Diet on Intestinal Microbiota and Kidney Oxidative Stress

et al. 2017

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There is controversial information about the adverse effect of sucrose (S) or fructose (F) in the development of obesity. Thus, the purpose of the study was to evaluate the effect of S or F in a high fat diet (HF) on gut microbiota and renal oxidative stress. Rats were fed for four months with either high-fat + sucrose (HFS) or high-fat + fructose (HFF) or a control diet (C). Half of the HFS or HFF groups were maintained with the same diet and the other half were switched to the consumption of C. HFS and HFF groups increased 51% and 19% body weight, respectively, compared with the C group. Body fat mass, metabolic inflexibility, glucose intolerance, lipopolysaccharide (LPS), insulin, renal reactive oxygen species (ROS), malondialdehyde (MDA), Nadphox, and Srebp-1 were significantly higher and antioxidant enzymes and lean body mass were significantly lower in the HFS group with respect to the HF-F group. Change in the consumption of HFS or HFF to a C diet ameliorated the insulin and glucose intolerance. The type of carbohydrate differentially modified the microbiota composition, however, both groups significantly decreased C. eutactus with respect to the C group. Thus, metabolic alterations with the HFS diet had a more detrimental effect than HFF.

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“…In line with these findings, Cani et al [93] found reduced hunger rates, increased postprandial GLP-1 and PYY, and decreased postprandial glucose responses in healthy volunteers treated with prebiotics. Probiotics, especially Lactobacillus strains, were also found to beneficially affect body weight, glucose-and lipid metabolism, and inflammatory status [94][95][96][97].…”

Section: Pre- Pro- and Antibioticsmentioning

confidence: 99%

The intestinal microbiota, energy balance, and malnutrition: emphasis on the role of short-chain fatty acids

Fluitman

Clercq

Keijser

et al. 2017

Expert Review of Endocrinology & Metabolism

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Introduction: Malnutrition refers to both over-and undernutrition and results from a disruption in energy balance. It affects one in three people worldwide and is associated with increased morbidity and mortality. The intestinal microbiota represents a newly identified factor that might contribute to the development of malnutrition, as it harbors traits that complement the human metabolic and endocrine capabilities, thereby influencing energy balance. Areas covered: In the current review, we aim to give a comprehensive overview on the microbiota, its development and its possible influence on energy balance, with emphasis the role of short-chain fatty acids. We also consider microbial characteristics associated with obesity and undernutrition and evaluate microbial manipulating strategies. The PubMed database was searched using the terms:

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Metabolic effects of Lactobacillus reuteriDSM 17938 in people with type 2 diabetes: A randomized controlled trial

Abstract: Intake of L. reuteri DSM 17938 for 12 weeks did not affect HbA1c in people with type 2 diabetes on insulin therapy; however, L. reuteri improved insulin sensitivity in a subset of participants and we propose that high diversity of the gut microbiota at baseline may be important.

Cited by 213 publications

References 35 publications

Obesity and diabetes—Not only a simple link between two epidemics

Obesity and diabetes—Not only a simple link between two epidemics

Differential Effect of Sucrose and Fructose in Combination with a High Fat Diet on Intestinal Microbiota and Kidney Oxidative Stress

The intestinal microbiota, energy balance, and malnutrition: emphasis on the role of short-chain fatty acids

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