Metabolic Effects of Honey in Type 1 Diabetes Mellitus: A Randomized Crossover Pilot Study

Abdulrhman, Mamdouh; El-Hefnawy, Mohamed H; Aly, R. H.; Shatla, Rania H.; Mamdouh, Rasha; Mahmoud, Doaa M.; Mohamed, Waheed S

doi:10.1089/jmf.2012.0108

Cited by 41 publications

(32 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The only study which can be considered long-term lasted 12 weeks. In the recently published article, Abdulrhman and colleagues reported that honey administration improved glycemia, lipid profile and adiposity in type 1 diabetic patients [27]. The longest duration of study in type 2 diabetes mellitus was 8 weeks.…”

Section: Beneficial Effects Of Honey In Diabetes Mellitus and Mattersmentioning

confidence: 99%

“…In the study, Bahrami et al reported the beneficial metabolic effects of honey in type 2 diabetic patients [28]. While the type 1 diabetes study did not measure the HbA1c levels [27], Bahrami and colleagues found that honey supplementation resulted in increased plasma levels of HbA1c in type 2 diabetic patients [28]. This is the only study that reported the potential detrimental effect of honey administration on glycemic control (HbA1c) in diabetic patients.…”

Section: Beneficial Effects Of Honey In Diabetes Mellitus and Mattersmentioning

confidence: 99%

See 1 more Smart Citation

Effect of honey in diabetes mellitus: matters arising

Erejuwa

2014

J Diabetes Metab Disord

View full text Add to dashboard Cite

Diabetes mellitus remains an incurable disorder in spite of intense research. As result of limitations and unmet goals associated with the use of anti-diabetic drugs, an increased number of diabetic populations globally now resort to complementary and alternative medicine (CAM) such as herbs and other natural products. There has been a renewed interest in the use of honey in the treatment of diabetes mellitus, partly due to an increase in the availability of evidence-based data demonstrating its benefits in diabetic rodents and patients. This commentary aims to underscore some of the research implications, issues and questions raised from these studies which show the beneficial effects of honey in the treatment of diabetes mellitus. Some of the issues highlighted in this article include: considering honey is sweet and rich in sugars, how could it be beneficial in the management of diabetes mellitus? Are the observed effects of honey or combined with anti-diabetic drugs exclusive to certain honey such as tualang honey? Could these beneficial effects be reproduced with other honey samples? Anti-diabetic drugs in combination with honey improve glycemic control, enhance antioxidant defenses and reduce oxidative damage. These effects are believed to be mediated partly via antioxidant mechanism of honey. This raises another question. Could similar data be obtained if anti-diabetic drugs are co-administered with other potent antioxidants such as vitamin C or E? As the evidence has revealed, the prospect of managing diabetes mellitus with honey or antioxidants (such as vitamin C or E) as an adjunct to conventional diabetes therapy is vast. However, more well-designed, rigorously conducted randomized controlled studies are necessary to further validate these findings.

show abstract

Section: Beneficial Effects Of Honey In Diabetes Mellitus and Mattersmentioning

confidence: 99%

Section: Beneficial Effects Of Honey In Diabetes Mellitus and Mattersmentioning

confidence: 99%

Effect of honey in diabetes mellitus: matters arising

Erejuwa

2014

J Diabetes Metab Disord

View full text Add to dashboard Cite

show abstract

“…The sugar-fed group (S16%) relative liver weight was significantly higher than normal control and the corresponding honey-fed group (H20%). This may suggest liver hypertrophy or inflammatory response to high levels of the sweeteners in the diet [25]. However, further studies involving liver histology and liver function test is needed for a conclusive report.…”

Section: Discussionmentioning

confidence: 99%

Effect of long-term feeding of the Obudu natural honey and table sugar-sweetened diets on obesity and pro-inflammatory biomarkers in rats

et al. 2020

View full text Add to dashboard Cite

Background: This study investigated long-term effect of the Obudu honey on selected biomarkers of energy storage regulation, compared to table sugar.Methods: Fifty Wistar rats assigned to 5 groups of 10 rats each, were fed rat chow only (NC), 8% table sugar (S8%), 16% table sugar (S16%), 10% honey (H10%) and 20% honey (H20%) diets respectively, for 29 weeks. On dry weight basis, the percentages of table sugar and honey for each level of incorporation were equivalent. Diet intake, body weights and fasting blood glucose (FBG) were measured fortnightly. At the end of the study, serum glucose, insulin, leptin and tissue necrosis factor -α (TNF-α), wet weight of white adipose tissues (WAT) were measured. Results: After an initial adjustment to the diets, there was no significant difference in diet consumed by female and male subgroups, except the female group fed H20% which was consistently lower than the NC and the corresponding S16% fed group (P < 0.05). Both honey and sugar incorporated diets caused significant body weight gain in the female animals compared to NC; an effect which was higher with the honey than sugar, and depended on the level of each sweetener used as well as feeding duration (P < 0.05). Furthermore, S8% and S16% diets increased leptin concentration in the female rats, by 35.8 and 45.3% respectively compared with NC and by 63.8 and 40.5% compared to H10% and H20% respectively (P < 0.05). Also, the S8% and S16% diets significantly increased serum insulin in the female subgroups compared to the corresponding honey-sweetened diets; and in both male and female rats when compared to NC (P < 0.05). Lastly, the S8% and S16% diets also caused a dosedependent increase of TNF-α in both female and male rats compared to the H10% and H20% diets and the control (P < 0.05).Conclusion: Data obtained from the study associated table sugar with obesigenic and inflammatory mechanisms more than the Obudu honey, particularly in the females. However, the data did not exempt the honey from obesigenic effect. The effects were subtle and may require a longer time to precipitate obesity.

show abstract

“…Honey oral rehydration solution promoted in Egypt for recovery from diarrhoea, vomiting and rehydration. [55] …”

Section: Honey In Primordial Egyptmentioning

confidence: 99%

Phytochemistry, metabolism, and ethnomedical scenario of honey: A concurrent review

Ahmad

Hussain

Saeed

et al. 2017

International Journal of Food Properties

View full text Add to dashboard Cite

Honey is a natural domestic sweet food material and a chemically diverse superfluous product of nectar acquired from flowers. Owing to the presence of higher amounts of antioxidant compounds covering phenolic, enzymes, organic acids, and bioactive peptides, it holds a strong ability to prevent various maladies. In addition, honey has also been exploited in certain cardiovascular, gastrointestinal, neoplastic, and inflammatory states along with its role in the treatment of copious infections and surgical wounds. Flavonoids and polyphenols are important bioactive components present in honey and have antioxidant properties. Some bioactive compounds, for example luteolin, galangin, isorhamnetin, quercetin, and kaempferol, are present in honey. Phenolic acids and flavonoids have important pharmacological activities such as anti-allergic, anti-biotic, anticarcinogenic, and hypoglycaemic. Moreover, curative potential of bioactive components and their utilisation in value added food products are also the limelight of this article. ARTICLE HISTORY

show abstract

Metabolic Effects of Honey in Type 1 Diabetes Mellitus: A Randomized Crossover Pilot Study

Cited by 41 publications

References 44 publications

Effect of honey in diabetes mellitus: matters arising

Effect of honey in diabetes mellitus: matters arising

Effect of long-term feeding of the Obudu natural honey and table sugar-sweetened diets on obesity and pro-inflammatory biomarkers in rats

Phytochemistry, metabolism, and ethnomedical scenario of honey: A concurrent review

Contact Info

Product

Resources

About