Metabolic effects of dietary supplementation of Lycium barbarum polysaccharides on serum and urine metabolomics in a young healthy male population

Xia, Hui; Tang, Huali; Wang, Feng; Yang, Xian; Wang, Zhaodan; Liu, Hechun; Pan, Da; Wang, Shaokang; Sun, Guiju

doi:10.1016/j.jff.2018.04.060

Cited by 14 publications

(11 citation statements)

References 34 publications

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“…The selected studies were published between 2009 and 2021. Four studies were conducted in China, [25,34,37,38] and 2 studies were carried out in Brazil and Singapore. [32,33] All trials had a parallel study design.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Five studies were conducted in both sexes, [25,32,33,37,38] and one study was conducted in healthy males. [34] RCTs were performed in various populations, including type 2 diabetes mellitus (1 trial), metabolic syndrome (1 trial), and healthy people (4 trials). Different L. barbarum supplement forms were used for the intervention.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…In addition, Chinese researchers have also conducted a clinical study to investigate the effects of LBP in the healthy male population at the metabolomics level. [34] An update on these previous meta-analyses is essential. Therefore, we conducted a systematic review and meta-analysis of RCTs investigating the effects of L. barbarum supplementation on lipid profiles in adults, which may provide a clearer view on the use of L. barbarum supplementation for dyslipidemia management.…”

Section: Introductionmentioning

confidence: 99%

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L. barbarum (Lycium barbarum L.) supplementation for lipid profiles in adults: A systematic review and meta-analysis of RCTs

Zeng,

Zhao,

Wang

et al. 2023

Medicine

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Background: Dyslipidemia is a global health concern with an increasing prevalence worldwide. Lycium barbarum (L. barbarum) is widely used as a medicinal and functional food, and evidence suggests that it may be beneficial for lipid management. In this study, we performed a systematic review and meta-analysis of randomized controlled trials investigating the effects of L. barbarum supplementation on lipid profiles in adults. Methods: PubMed, China National Knowledge Infrastructure, The Cochrane Library, Web of Science, and Wanfang Database were searched from inception until October 2022. The random-effect model was applied, and the pooled effect sizes were expressed as mean differences (MDs) and 95% confidence intervals (CIs). Results: The meta-analysis of 5 randomized controlled trials involving 259 subjects indicated that L. barbarum supplementation significantly decreased the triglyceride (TG) concentration (MD: 0.14 mmol/L, 95% CI: 0.08–0.20) and increased the high-density lipoprotein cholesterol concentration (HDL-C) (MD: −0.07 mmol/L, 95% CI: −0.13 to −0.01). However, the reductions in total cholesterol (TC) concentration (MD: 0.11 mmol/L, 95% CI: −0.37 to 0.59) and low-density lipoprotein cholesterol (LDL-C) concentration (MD: 0.21 mmol/L, 95% CI: −0.46 to 0.89) were not statistically significant. Conclusion: The present study showed that L. barbarum supplementation might have some beneficial effects on TG and HDL-C concentrations in adults, and L. barbarum fruit has an even greater effect on TG and HDL-C concentrations. Considering the sensitivity analyses and limitations of the study included, further large-scale studies are needed to confirm these findings.

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Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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L. barbarum (Lycium barbarum L.) supplementation for lipid profiles in adults: A systematic review and meta-analysis of RCTs

Zeng,

Zhao,

Wang

et al. 2023

Medicine

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“…Lycium barbarum (goji berry) leaf is a Chinese herb that has been associated with health benefits and used as a food supplement and traditional medicine for its anti-oxidation, anti-inflammation, anti-diabetes, and anti-cancer effects. − Plenty of studies have been devoted to the relationship of goji berry polysaccharides and bioactivities. − However, the goji leaf polysaccharide has received less attention, and there are few studies about its extraction, structure, and function, resulting in insufficient utilization of byproducts from goji processing. Therefore, herein, we performed sequential extraction using 1,2-cyclohexanediaminetetraacetic acid (CDTA), sodium carbonate, and sodium hydroxide on goji berry leaves to obtain structurally different polysaccharides.…”

Section: Introductionmentioning

confidence: 99%

Structure and In Vitro Fermentation Characteristics of Polysaccharides Sequentially Extracted from Goji Berry (Lycium barbarum) Leaves

Ahmadi

et al. 2022

J. Agric. Food Chem.

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Herein, the chelating agent-soluble fraction (CA), sodium carbonate-soluble fraction (SC), and sodium hydroxide-soluble fraction (SH) were sequentially extracted from the cell wall of goji berry (Lycium barbarum) leaves. Furthermore, SC was purified with Q-Sepharose fast flow resin to obtain the neutral sugar fraction (SC-I) and acid sugar fraction (SC-II). Physicochemical properties of polysaccharides were characterized by high-performance anion-exchange chromatography with pulsed amperometry detection, size exclusion chromatography–multi-angle laser light scattering, Fourier transform infrared spectroscopy, nuclear magnetic resonance, and atomic force microscopy analysis. Additionally, the impact of polysaccharides on modulating human gut microbiota was investigated by in vitro fermentation. A high amount of galacturonic acid (GalA) in CA showed that it was an aggregation of linear homogalacturonan. SC was the main pectic polysaccharide fraction and rich in neutral sugars. SC-I was the neutral sugar fraction with an extremely high molecular weight (2.055 × 106 Da), while SC-II was the acid sugar fraction with a low molecular weight (1.766 × 105 Da). SH seemed like a mixture of pectin and hemicellulose. All the five polysaccharides significantly (P < 0.05) increased the abundance of Bacteroides, Bifidobacteria, and Lactobacilli. To the best of our knowledge, this is the first report on the structure and fermentation characteristics of goji berry leaf polysaccharides, which is meaningful to provide a structural basis for further bioactivity research.

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“…Serum samples usually represent for low polar metabolites, while urine samples are composed of high polar ones. These two complement each other and stand for the globe features to obtain comprehensive understandings about the mechanism of drug, prognosis and sensitivity prediction to clinical treatments [27,28,29]. However, a myriad of metabolites and their broad range of concentrations limit the understanding of biological process of disease using the metabolomics alone.…”

Section: Introductionmentioning

confidence: 99%

Interpretation of Euphorbia Kansui Stir-Fried with Vinegar Treating Malignant Ascites by a UPLC-Q-TOF/MS Based Rat Serum and Urine Metabolomics Strategy Coupled with Network Pharmacology

Zhang

Wang

et al. 2018

Molecules

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Euphorbia kansui stir-fried with vinegar (V-kansui) has promising biological activities toward treating malignant ascites with reduced toxicity compared to crude kansui. But the mechanism concerning promoting the excretion of ascites has not been systematically studied. The purpose of this paper was to investigate the possible mechanism of V-kansui in treating malignant ascites, including metabolic pathways and molecular mechanism using an integrated serum and urine metabolomics coupled with network pharmacology. Serum and urine samples of rats were collected and analyzed by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS). A comparison with crude kansui was also made to demonstrate the feasibility of processing. Principle component analysis (PCA) and orthogonal partial least square discriminate analysis (OPLS-DA) were conducted to discriminate the groups, search important variables and reveal the possible pathways. A compound-target-metabolite network was finally constructed to identify the crucial targets to further understand the molecular mechanism. Sixteen significant metabolites contributing to the discrimination of model and control groups were tentatively screened out. They were mainly involved in the arachidonic acid metabolism, steroid hormone biosynthesis and primary bile acid to possibly reduce inflammatory and modulate the renin-angiotensin-aldosterone system to achieve treating malignant ascites. A bio-network starting from the compounds and ending in the metabolites was constructed to elucidate the molecular mechanism. HSP90AA1, ANXA2, PRDX6, PCNA, SOD2 and ALB were identified as the potential key targets that were responsible for the treatment of malignant ascites by the parameter combining the average shortest path length and betweenness centrality. The correlated 17 compounds were considered as the potential active ingredients in V-kansui. In addition, the metabolomics showed that the effect of V-kansui was almost in accordance with crude kansui. These results systematically revealed the mechanism of V-kansui against malignant ascites for the first time using metabolomics coupled with network pharmacology. V-kansui could be a promising safe and therapeutic medicine for the excretion of ascites.

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Metabolic effects of dietary supplementation of Lycium barbarum polysaccharides on serum and urine metabolomics in a young healthy male population

Cited by 14 publications

References 34 publications

L. barbarum (Lycium barbarum L.) supplementation for lipid profiles in adults: A systematic review and meta-analysis of RCTs

L. barbarum (Lycium barbarum L.) supplementation for lipid profiles in adults: A systematic review and meta-analysis of RCTs

Structure and In Vitro Fermentation Characteristics of Polysaccharides Sequentially Extracted from Goji Berry (Lycium barbarum) Leaves

Interpretation of Euphorbia Kansui Stir-Fried with Vinegar Treating Malignant Ascites by a UPLC-Q-TOF/MS Based Rat Serum and Urine Metabolomics Strategy Coupled with Network Pharmacology

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