Metabolic dysregulation of tricarboxylic acid cycle and oxidative phosphorylation in glioblastoma
Cristina Trejo-Solís,
Norma Serrano-García,
Rosa Angelica Castillo-Rodríguez
et al.
Abstract:Glioblastoma multiforme (GBM) exhibits genetic alterations that induce the deregulation of oncogenic pathways, thus promoting metabolic adaptation. The modulation of metabolic enzyme activities is necessary to generate nucleotides, amino acids, and fatty acids, which provide energy and metabolic intermediates essential for fulfilling the biosynthetic needs of glioma cells. Moreover, the TCA cycle produces intermediates that play important roles in the metabolism of glucose, fatty acids, or non-essential amino … Show more
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