Metabolic Disorders After Liver Transplantation

Gitto, Stefano; Falcini, Margherita; Marra, Fabio

doi:10.1089/met.2020.0068

Cited by 10 publications

(8 citation statements)

References 55 publications

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“…Among them, the liver, as the main metabolic organ, is the critical hub for the maintenance of oxidative balance, the regulation of the metabolism of three major nutrients, the replenishment of the immune system, the regulation of lipid and cholesterol homeostasis, and the catabolism of drugs and poisons. , Studies have found that fluoride could affect metabolic function, reduce detoxification ability, and cause metabolic disorders in the liver . Metabolic disorders will lead to growth and developmental disorders in humans and animals and reduce the production performance of livestock and poultry . In addition, the reduction of detoxification ability will lead to the accumulation of harmful substances, which will affect the health of humans and animals and the safety of animal food .…”

Section: Introductionmentioning

confidence: 99%

“…5 Metabolic disorders will lead to growth and developmental disorders in humans and animals and reduce the production performance of livestock and poultry. 6 In addition, the reduction of detoxification ability will lead to the accumulation of harmful substances, which will affect the health of humans and animals and the safety of animal food. 7 Hence, it has important practical significance to explore the toxicity mechanism of fluoride-induced hepatic injury and search effective preventive and cure measures for the health and the sustainable development of humans and animals.…”

Section: ■ Introductionmentioning

confidence: 99%

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α-Lipoic Acid Alleviated Fluoride-Induced Hepatocyte Injury via Inhibiting Ferroptosis

Zhao

Liu

Liang

et al. 2022

J. Agric. Food Chem.

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Fluoride is widely used in agricultural production and food packaging. Excessive fluoride in water and food is a serious threat to liver health. α-Lipoic acid, a natural free radical scavenger, has hepatoprotective properties. However, the protective effect of α-lipoic acid on fluorohepatotoxicity is uncertain. The aim of this study was to investigate the mechanism of ferroptosis in α-lipoic acid preventing fluoride-induced hepatotoxicity. Five-week-old ICR mice were treated with sodium fluoride (100 mg/L) and/or α-lipoic acid (200 mg/kg) for 9 weeks. The results showed that α-lipoic acid attenuated fluoride-induced damage to liver morphology and ultrastructure. Moreover, α-lipoic acid alleviated fluoride-induced iron accumulation, increased oxidative stress, and elevated lipid peroxidation in the liver. In addition, the mechanism study found that α-lipoic acid prevented fluoride-induced ferroptosis through the System Xc–/GPX4 axis, lipid peroxidation axis, and iron metabolism axis, but it was interestingly not regulated by mitochondrial free radical axis in the hepatocytes. Altogether, this study indicated that α-lipoic acid prevents fluoride-induced liver injury by inhibiting ferroptosis, which has potential implications for the prevention and treatment of fluoride-induced liver injury.

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Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

α-Lipoic Acid Alleviated Fluoride-Induced Hepatocyte Injury via Inhibiting Ferroptosis

Zhao

Liu

Liang

et al. 2022

J. Agric. Food Chem.

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“…Typically, as a first-line therapeutic approach, calcium channel blockers are used, primarily for their vasodilatory effect on the hepatic artery [28]. In secondary consideration, selective beta-receptor blockers, angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, and loop diuretics are employed, with special attention to renal function [29,30]. The initiation of antihypertensive therapy should be preceded by lifestyle modifications, including weight loss, if necessary, increased physical activity, and a reduction in sodium intake.…”

Section: Arterial Hypertensionmentioning

confidence: 99%

Metabolic Disorders in Liver Transplant Recipients: The State of the Art

Gabrielli,

Golfieri,

Nascimbeni

et al. 2024

JCM

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Liver transplantation represents a chief therapeutic approach for acute liver failure, end-stage liver disease and hepatocellular carcinoma. Despite witnessing advancements in short- and medium-term survival over recent decades, attributed to refinements in surgical techniques and immunosuppressive protocols, long-term mortality remains impervious to modification. Notably, cardiovascular disease emerges as a predominant cause of mortality among liver transplant recipients. This trend is accentuated by the increasing prominence of non-alcoholic steatohepatitis-related cirrhosis as an indication for liver transplantation. Moreover, the administration of immunosuppressive agents is intricately linked to the degradation of the metabolic profile in liver transplant recipients, thereby contributing to the initiation or exacerbation of cardiovascular risk factors, such as hypertension, diabetes, and dyslipidaemia. In addition, the post-liver transplantation period is marked by a decline in lifestyle quality and a failure to acknowledge the psychological distress experienced by patients throughout the transplant process. These factors can precipitate a deterioration in the patient’s metabolic profile, exacerbated by suboptimal therapeutic compliance. This narrative review aims to comprehensively address the principal metabolic disorders intricately associated with liver transplantation.

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“…The development of post-LT metabolic syndrome is frequent[ 56 ]. In addition to lingering pre-LT risk factors, there is an increase in post-LT risks due to immunosuppression with corticosteroids and CNI[ 57 ].…”

Section: Causes Of Renal Dysfunction In Ltmentioning

confidence: 99%

Current aspects of renal dysfunction after liver transplantation

Pacheco¹,

Carneiro-D’Albuquerque²,

Mazo³

2022

WJH

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The development of chronic kidney disease (CKD) after liver transplantation (LT) exerts a severe effect on the survival of patients. The widespread adoption of the model for end-stage liver disease score strongly impacted CKD incidence after the procedure, as several patients are transplanted with previously deteriorated renal function. Due to its multifactorial nature, encompassing pre-transplantation conditions, perioperative events, and nephrotoxic immunosuppressor therapies, the accurate identification of patients under risk of renal disease, and the implementation of preventive approaches, are extremely important. Methods for the evaluation of renal function in this setting range from formulas that estimate the glomerular filtration rate, to non-invasive markers, although no option has yet proved efficient in early detection of kidney injury. Considering the nephrotoxicity of calcineurin inhibitors (CNI) as a factor of utmost importance after LT, early nephroprotective strategies are highly recommended. They are based mainly on delaying the application of CNI during the immediate postoperative-period, reducing their dosage, and associating them with other less nephrotoxic drugs, such as mycophenolate mofetil and everolimus. This review provides a critical assessment of the causes of renal dysfunction after LT, the methods of its evaluation, and the interventions aimed at preserving renal function early and belatedly after LT.

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Metabolic Disorders After Liver Transplantation

Cited by 10 publications

References 55 publications

α-Lipoic Acid Alleviated Fluoride-Induced Hepatocyte Injury via Inhibiting Ferroptosis

α-Lipoic Acid Alleviated Fluoride-Induced Hepatocyte Injury via Inhibiting Ferroptosis

Metabolic Disorders in Liver Transplant Recipients: The State of the Art

Current aspects of renal dysfunction after liver transplantation

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