Metabolic dialogues: regulators of chimeric antigen receptor T cell function in the tumor microenvironment
Josquin Moraly,
Taisuke Kondo,
Mehdi Benzaoui
et al.
Abstract:Tumor‐infiltrating lymphocytes (TILs) and chimeric antigen receptor (CAR) T cells have demonstrated remarkable success in the treatment of relapsed/refractory melanoma and hematological malignancies, respectively. These treatments have marked a pivotal shift in cancer management. However, as “living drugs,” their effectiveness is dependent on their ability to proliferate and persist in patients. Recent studies indicate that the mechanisms regulating these crucial functions, as well as the T cell's differentiat… Show more
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