Metabolic control of glucose degradation in yeast and tumor cells

Fiechter, Armin; Gmünder, Felix K.

doi:10.1007/bfb0051950

Cited by 36 publications

(25 citation statements)

References 99 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this respect, C. maltosa is obviously similar to C. tropicalis classified as glucose-insensitive and 02-sensitive yeast. In contrast, obligatory oxidative yeasts like Y. lipolytica and Trichosporon cutaneum produce no or low amounts of ethanol during growth on glucose (Fiechter et al 1987;Fiechter and Gmiinder 1989).…”

Section: And 32)mentioning

confidence: 94%

Candida maltosa

Mauersberger

Ohkuma

Schunck

et al. 1996

Nonconventional Yeasts in Biotechnology

View full text Add to dashboard Cite

Section: And 32)mentioning

confidence: 94%

Candida maltosa

Mauersberger

Ohkuma

Schunck

et al. 1996

Nonconventional Yeasts in Biotechnology

View full text Add to dashboard Cite

“…A key step in controlling the rate of glycolysis in mammalian cells is the phosphofructokinase (PFK) reaction [for review of PFK see ref. [18][19][20][21]. The enzyme is negatively modulated by citrate and by ATP.…”

Section: Glucose Metabolism and Citratementioning

confidence: 99%

The Intermediary Metabolism of the Prostate: A Key to Understanding the Pathogenesis and Progression of Prostate Malignancy

Costello¹,

Franklin²

2000

Oncology

223

209

View full text Add to dashboard Cite

This review emphasizes the importance and role of altered intermediary metabolism of prostate cells in the pathogenesis of prostate adenocarcinoma (PCa) and the progression of malignancy. The focus of the presentation is a summary of the overwhelming evidence which implicates the metabolic transformation of citrate-producing sane cells to citrate-oxidizing malignant cells in the process of malignancy. The evidence now demonstrates that altered zinc accumulation is an important factor in this transformation. These metabolic relationships are uniquely different from the metabolic alterations associated with tumorigenesis of other mammalian cells. The metabolic transformation of zinc-accumulating citrate-producing normal prostate epithelial cells to citrateoxidizing malignant cells has important implications on cellular bioenergetics, cell growth and apoptosis, lipogenesis, angiogenesis. Based on the metabolic considerations new concepts concerning the pathogenesis, diagnosis and treatment of prostate malignancy are presented. Unfortunately the metabolism of the prostate has been a seriously neglected and largely ignored area of prostate research. The importance of expanded research into the intermediary metabolism of normal and neoplastic prostate is essential to future significant advances in understanding and dealing with PCa. As an aside point, the reprint that I possess and treasure was personally inscripted and presented to me by Dr. Huggins over a decade ago. I was reminded that Dr. Huggins did present data that demonstrated that prostate tissue citrate levels were markedly decreased in prostate cancer. Although not emphasized by Dr. Huggins, to our knowledge this is the first report of the association of low citrate levels with prostate cancer. In our recent reviews and presentations we have credited the 1959 report of Cooper and Imfeld [24] as the first reported of this relationship. Cooper and Imfeld [24] did extend the earlier data of Huggins by the inclusion of normal prostate tissue analysis, and they directed specific attention to the significance of the low citrate values in prostate cancer. The pursuant report of Cooper and Farid [23] in 1964 provided the most comprehensive study at that time which substantiated the citrate relationships in normal prostate, BPH, and prostate cancer. Thus Huggins and his colleagues along with Cooper and colleagues share in the initial revelation of citrate relationships in prostate cancer. I regret the earlier omissions of the report of Dr. Huggins in some of our presentations. I should apologize in advance for any other early initial reports that I might have missed, and I would appreciate being advised of any corrections to this presentation.

show abstract

“…In the latter case, the mitochondrial respiratory chain is in operation and the production of reactive oxygen species can be expected to be significantly augmented as an unavoidable by-product of oxidation, assuming the mitochondria are the main cellular sources of superoxide [1][2][3]. The control of yeast metabolic pathways is complex [4][5][6][7][8], involving not only the induction/repression of enzymes directly active in the metabolism of the appropriate substrates, but also affecting the level of antioxidants and antioxidant enzymes. There is little data in the literature on the effect of the growth phase and a change in the carbon source on the antioxidant barrier in various strains of S. cerevisiae.…”

Section: Introductionmentioning

confidence: 99%

The effect of growth medium on the antioxidant defense of Saccharomyces cerevisiae

Macierzyńska

Grzelak

Bartosz

2007

Cellular and Molecular Biology Letters

View full text Add to dashboard Cite

Abbreviations used: DTNB -5,5'-dithiobis-(2-nitrobenzoic acid); H 2 R 123 -dihydrorhodamine 123; MES -2-morpholinoethanesulfonic acid; ROS -reactive oxygen species; SOD -superoxide dismutase; YPD medium -1% yeast extract, 1% Bacto-peptone, 2% glucose, YPG medium, 1% yeast extract, 1% Bacto-peptone,2% glycerol; YPE medium -1% yeast extract, 1% Bacto-peptone, 3% ethanol Abstract: We compared the oxidation of dihydrorhodamine 123, glutathione contents and activities of superoxide dismutase (SOD) and catalase for three wild-type strains of Saccharomyces cerevisiae grown on media with different carbon sources. The rate of oxidation of dihydrorhodamine 123 was much higher in respiring cells grown on ethanol or glycerol media than in fermenting cells grown on glucose medium. The total SOD activity was highest on glycerol medium and lowest on ethanol medium, while the catalase activity was highest on glycerol medium. The sequence of glutathione content values was: glucose > ethanol > glycerol.

show abstract

Metabolic control of glucose degradation in yeast and tumor cells

Cited by 36 publications

References 99 publications

Candida maltosa

Candida maltosa

The Intermediary Metabolism of the Prostate: A Key to Understanding the Pathogenesis and Progression of Prostate Malignancy

The effect of growth medium on the antioxidant defense of Saccharomyces cerevisiae

Contact Info

Product

Resources

About