Metabolic consequences of portacaval shunting in the rat

Assal, Jean‐Philippe; Levrat, R; Cahn, T; Renold, Albert E.

doi:10.1007/bf02048382

Cited by 33 publications

(12 citation statements)

References 7 publications

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“…There is no evidence for intestinal malabsorption [20]. In our study the application of cholesterol-free food eliminates the possibility of reduced exogenous cholesterol intake as compared with control animals.…”

Section: Cholesterol or Diminished Reabsorption Of Endogenous Cholestmentioning

confidence: 64%

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Effect of portacaval anastomosis on hepatic HMG‐CoA‐reductase activity in normal rats

Bützow¹,

Ossenberg²,

Becker³

et al. 1977

FEBS Letters

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Section: Cholesterol or Diminished Reabsorption Of Endogenous Cholestmentioning

confidence: 64%

“…Diminished reabsorption of endogenous cholesterol is unlikely because the lipid content of the faeces in rats with pea equals that of untreated animals. [20].…”

Section: Cholesterol or Diminished Reabsorption Of Endogenous Cholestmentioning

confidence: 99%

Effect of portacaval anastomosis on hepatic HMG‐CoA‐reductase activity in normal rats

Bützow¹,

Ossenberg²,

Becker³

et al. 1977

FEBS Letters

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“…Encephalopathy, testicular atrophy, hyperoestrogenism, gastric hypersecretion with ulcera tions, changes in plasma proteins, bile acid metabolism, uric acid excretion, and urine volume among others have been reported [1,10,19,20,24]. One of the most fundamental sequelae of portal blood diversion, however, is reduction in liver size.…”

Section: Discussionmentioning

confidence: 99%

Liver Enzymes in the Eck Fistula Rat

Colombo

Herz

Bircher

1972

Enzyme

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The paper considers whether shunting of portal blood around the liver and decreased total hepatic blood flow are sufficient to explain the degree of hyperammonemia occurring after portacaval shunt (PCS). For this purpose, urea-cycle enzymes, transaminases, and glutamatedehydrogenase were measured in rat-liver homogenates 10, 20, and 30 days after PCS and compared to unoperated controls. In view of the marked postoperative reduction of liver mass, three typical responses could be observed : type I, normal or slightly decreased enzyme activity per gram of liver, but decreased per total liver mass (ornithine carbamyltransferase, argininosuccinate synthetase, arginase, glutamate pyruvate, and oxaloacetate transaminase, glutamate dehydrogenase); type II, increased enzyme activity per gram liver, but decreased per total liver mass (carbamylphosphate synthetase); type III, increased enzyme activity per gram liver but normal per total-liver mass (argininosuccinate cleavage enzyme). Particu - larly, the rate-limiting step of the urea cycle (argininosuccinate synthetase) showed a type-I response. The data suggest that liver ‘atrophy’ after PCS is associated with a reduction of functional enzyme content. This represents at least one factor contributing to hyperammonemia in this experimental model.

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“…In shunted animals, a decrease in liver and body weight during the first days after the operation has been a general experience in this and other laboratories (1,7,15,19). This implies a PCS which functions well.…”

Section: Ggtp After Pcsmentioning

confidence: 73%

“…The microscopical anatomy of the liver of shunted rats looks grossly cormal (1,19). The generally recognized minor morphologic alterations of the liver tissue do not appear to be sufficient to explain the observed enzymatic changes.…”

Section: Groupmentioning

confidence: 99%

γ-Glutamyltranspeptidase in the Rat Liver after Portacaval Shunt

et al. 1976

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Extractweight have been re~orted (I. 15). The metabolism of bile salts and y-Glutamyltranspeptidase (GGTP) activity was studied in livers of rats submitted to an end-to-side portacaval shunt (PCS) and in developing animals. To correlate the evolution of the enzymatic activity measured in vitro, histochemical techniques were used to localize enzyme activity in liver tissue. The GGTP activity in the adult rats was low and amounted to 2.0 =k 0.1 pmol/min/g. During fetal development the enzyme activity rose beginning on the 15th gestational day from 630 A 97 to 1,058 + 20 on the first postnatal day. I'hen the values declined and reached nearly adult values from the 10th postnatal day.After PCS the GGTP activity exhibited a three-to sixfold increase (130 + 69 to 371 + 131) as compared with uneperated adult controls (53 & 13). The highest levels corresponded to those observed between the 3rd and 5th postnatal day in the developing rats. The histochemistry of GGTP in the fetal and newborn liver showed a regular distribution of the enzyme as a fine deposit in the hepatocytes throughout the whole tissue. Ten days after birth the activity was low, at the same level as in the adult rat. In the period after P C S hepatocytes began to show signs of enzymatic activity at the periphery of the hepatic lobules, which subsequently spread through the whole lobules. The increase of GGTP activity after P C S equaled the activity found in fetal animals. That correlated well in both groups with the reappearance of histologically demonstrable enzyme activity in hepatocytes. SpeculationThe consequences of portacaval shunt might be associated with the derepression of an enzyme normally present only in fetal and neonatal rat liver. Since GGTP plays a role in the y-glutamyl cycle, and is responsible, supposedly, for the transport of amino acids into the cell, it may be that in fetal liver and after P C S augmented cellular amino acid transport is an expression of growth and transformation processes.The end-to-side PCS in the rat represents an appropriate model to study experimental hyperammonemia (7, 15) because of the shunting of portal blood to the systemic circulation. In addition to hyperammonemia, portacaval shunting leads to marked changes of the quantity and composition of the blood reaching the liver. The consequences of the shunt operation are therefore multiple. Encephalopathy, testicular atrophy, and changes in body and liver of certain amino ac'ids seeks to'be affected as well (14,(24)(25)(26).These significant morphologic and functional changes are likely to be interpreted as a consequence of shunt-induced alterations in the metabolic stimulation of the liver. Despite considerable work in this field, no common denominator has been found to define the underlying hepatic process of the transformations induced by PCS. To our knowledge the specific hypothesis has not been tested of whether some of the consequences of PCS on hepatic metabolism might be considered as a regression of the liver cell function to a more immature or embr...

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Metabolic consequences of portacaval shunting in the rat

Cited by 33 publications

References 7 publications

Effect of portacaval anastomosis on hepatic HMG‐CoA‐reductase activity in normal rats

Effect of portacaval anastomosis on hepatic HMG‐CoA‐reductase activity in normal rats

Liver Enzymes in the Eck Fistula Rat

γ-Glutamyltranspeptidase in the Rat Liver after Portacaval Shunt

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