Metabolic component of acute left ventricular failure treatment in patients who underwent on-pump coronary artery bypass grafting

Abstract

Aim: To study the effectiveness of the use of a combination of L-carnitine and arginine to improve the results of treatment of cardiac surgery patients with acute left ventricular failure who underwent CABG with cardiopulmonary bypass (CPB). Material and methods: 500 patients were operated. All of them underwent CABG with CPB. Sixty patients who required inotropic support in the postoperative period were selected. The patients were divided into two groups of 30 people each. Inotropic support with dobutamine and metabolic support with a combination of levocarnitine and arginine were used to stabilize hemodynamics in the basic group. Stabilization was performed with dobutamine alone in the control group. Results: The venous saturation during the period of hemodynamic stabilization was higher in basic group. In the basic group, the recovery time of hemodynamics and the total dose of the inotropic drug were shorter/lower than in the control one. Conclusions: The groups of patients were homogeneous and the process of hemodynamic stabilization was achieved in both groups. The combination of Levocarnitine and Arginine has a pronounced antihypoxic effect on the myocardium. Using this combination can reduce the hemodynamic recovery time by 1.3 times and reduce the total dose of the inotropic drug by 1.33 times.