Metabolic comparison of radiolabeled aniline- and phenol-phthaleins with 131I

Avcıbaşı, Uğur; Avcıbaşı, Nesibe; Ünak, Turan; Ünak, Perıhan; Müftüler, Fazilet Zümrüt Biber; Yıldırım, Yeliz; Dinçalp, Haluk; Gümüşer, Fikriye Gül; Dursun, Ebru Rükşen

doi:10.1016/j.nucmedbio.2008.02.003

Cited by 9 publications

(2 citation statements)

References 24 publications

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“…BLMG was enzymatically synthesized using microsome preparates separated from rat liver. 23 Their preliminary biological activities in the rabbit metabolism were examined using gamma camera imaging technique, and biodistribution studies. Na 99m TcO 4 was supplied by the Department of Nuclear Medicine of Ege University, as 99 Mo/ 99m Tc generator eluent (Monrol, Turkey).…”

Section: Methodsmentioning

confidence: 99%

Metabolic Comparison of Radiolabeled Bleomycin and Bleomycin-Glucuronide Labeled with ^99mTc

Koçan

Avcıbaşı²,

Ünak³

et al. 2011

Cancer Biotherapy and Radiopharmaceuticals

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The metabolic comparison of bleomycin (BLM) and bleomycin-glucuronide (BLMG) radiolabeled with (99m)Tc ((99m)Tc-BLM and (99m)Tc-BLMG, respectively) has been investigated in this study. Quality control procedures were carried out using thin-layer radiochromatography and high-performance liquid chromatography. To compare the metabolic behavior of BLM and its glucuronide conjugate radiolabeled with (99m)Tc, scintigraphic, and biodistributional techniques were applied using male New Zealand rabbits and Albino Wistar rats. The results obtained have shown that these compounds were successfully radiolabeled with a labeling yield of about 100%. Maximum uptakes of (99m)Tc-BLM and (99m)Tc-BLMG metabolized as N-glucuronide were observed within 2 hours in the liver, the bladder, and the spinal cord for (99m)Tc-BLM and the lung, the liver, the kidney, the large intestine, and the spinal cord for (99m)Tc-BLMG, respectively. Scintigraphy and biodistributional studies performed on the experimental animals have shown that radiopharmaceutical potentials of these compounds are completely different. At the same time, uptake of the (99m)Tc-BLMG was found to be better than that of (99m)Tc-BLM.

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Section: Methodsmentioning

confidence: 99%

Metabolic Comparison of Radiolabeled Bleomycin and Bleomycin-Glucuronide Labeled with ^99mTc

Koçan

Avcıbaşı²,

Ünak³

et al. 2011

Cancer Biotherapy and Radiopharmaceuticals

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“…It has been used to label various biomolecules [14][15][16][17][18] such as proteins, peptides, and antibodies [19,20]. Regarding with Lec, V. Album agglutinin [21], phytohemagglutinin-L [22], and Viscum album agglutinin-I Lec [21] were labeled with 125 I via iodogen method to show receptor ligand interactions.…”

Section: Radioiodinationmentioning

confidence: 99%

Radioiodine labeled CdSe/CdS quantum dots: Lectin targeted dual probes

et al. 2014

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CdSe/CdS quantum dots (QD) were synthesized and bioconjugated with Sambucus nigra agglutinin (SNA) lectin (Lec). Mannose triflate and cysteamine molecules (MTC) were also utilized to prepare MTC-QDs and MTCQDs-Lec probes as well as Lec bound QDs. Afterwards; potential use of these nanoparticles as radiolabeled fluorescence nano-probes for the cell imaging studies has been investigated. Biological activities of 125 I − , 125 I-MTCQDs, MTC-QDs-Lec-125 I, QDs-Lec-125 I and Lec-125 I were examined on various cancer cell lines such as Caco-2, MCF-7 and A-549 in terms of cell incorporation. QDs-Lec-125 I exhibited the highest cell incorporation on whole celllines. In addition, the QDs-Lec-131 I, was used for in vivo imaging. The whole body distribution of the radiolabeled QDs on New Zealand rabbits and Balb C mice were examined by taking dynamic and static images. Radioactivity cleared from the kidneys and the bladder, while significant amount radioactivity was retained in the heart and liver within 24 h.

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1,6‐Addition Arylation of para‐Quinone Methides: An Approach to Unsymmetrical Triarylmethanes

Gao

Yuan

et al. 2016

Eur J Org Chem

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A 1,6‐addition arylation reaction of para‐quinone methides with α‐isocyanoacetamides and electron‐rich aromatic compounds under metal‐free conditions has been developed. BF3·Et2O plays two roles in the reaction: catalyzing the cyclization of α‐isocyanoacetamides to give oxazoles, and activating the para‐quinone methides to achieve the 1,6‐addition arylation process. The reaction shows good functional group tolerance, scalability, and regioselectivity. It is a consice protocol for the synthesis of diverse unsymmetrical triarylmethanes. Further transformation of the resulting triarylmethanes provides an efficient route to some functionalized molecules.

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Metabolic comparison of radiolabeled aniline- and phenol-phthaleins with 131I

Cited by 9 publications

References 24 publications

Metabolic Comparison of Radiolabeled Bleomycin and Bleomycin-Glucuronide Labeled with ^99mTc

Metabolic Comparison of Radiolabeled Bleomycin and Bleomycin-Glucuronide Labeled with ^99mTc

Radioiodine labeled CdSe/CdS quantum dots: Lectin targeted dual probes

1,6‐Addition Arylation of para‐Quinone Methides: An Approach to Unsymmetrical Triarylmethanes

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Metabolic comparison of radiolabeled aniline- and phenol-phthaleins with 131I

Cited by 9 publications

References 24 publications

Metabolic Comparison of Radiolabeled Bleomycin and Bleomycin-Glucuronide Labeled with 99mTc

Metabolic Comparison of Radiolabeled Bleomycin and Bleomycin-Glucuronide Labeled with 99mTc

Radioiodine labeled CdSe/CdS quantum dots: Lectin targeted dual probes

1,6‐Addition Arylation of para‐Quinone Methides: An Approach to Unsymmetrical Triarylmethanes

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Product

Resources

About

Metabolic Comparison of Radiolabeled Bleomycin and Bleomycin-Glucuronide Labeled with ^99mTc

Metabolic Comparison of Radiolabeled Bleomycin and Bleomycin-Glucuronide Labeled with ^99mTc