Metabolic characterization of breast tumors with positron emission tomography using F-18 fluorodeoxyglucose.

Avril, Norbert; Dose, J.; Jänicke, F.; Bense, Sandra; Ziegler, Sibylle; Laubenbacher, C.; Römer, Wolfgang; Pache, H; Herz, Michael; Allgayer, B; Nathrath, W; Graeff, H.; Schwaiger, Markus

doi:10.1200/jco.1996.14.6.1848

Cited by 215 publications

(118 citation statements)

References 22 publications

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“…In a larger patient group, Avril et al reported a sensitivity and specificity for the detection of primary breast cancer of 88% and 78%, respectively [18]. For small tumours, only low sensitivity was achieved.…”

Section: Histopathologymentioning

confidence: 99%

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Scintimammography with technetium-99m methoxyisobutylisonitrile: results of a prospective European multicentre trial

Palmedo

Biersack

Lastoria³

et al. 1998

European Journal of Nuclear Medicine and Molecular Imaging

108

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Abstract. The aim of the trial was to determine the diagnostic accuracy of scintimmammography with technetium-99m methoxyisobutylisonitrile ( 99m Tc-MIBI) in the detection of primary breast cancer and to verify its clinical usefulness. A total of 246 patients with a suspicious breast mass or positive mammogram were included in this prospective European multicentre trial. At 5 min and 60 min (optional) p.i. two lateral prone images were acquired for 10 min each; 30 min p.i. one anterior image was acquired for 10 min. There were 253 lesions (195 palpable and 58 non-palpable), in respect of which histology revealed 165 cancers and 88 benign lesions. Institutional and blinded read results were correlated to core laboratory histopathology results obtained during excisional biopsy. Diagnostic accuracy for the detection of breast cancer was calculated per lesion. The overall sensitivity and specificity of blinded read scintimammography were 71% and 69%, respectively. For palpable lesions, the sensitivity of blinded read and institutional read scintimammography was 83% and 91%, respectively. Sensitivity was not dependent on the density of the breast tissue. Invasive ductal and invasive lobular cancers showed similar sensitivity. The sensitivity and specificity of mammography were 91% and 42%, respectively, and did not depend on the tumour size. In 60% of false-negative mammograms, 99m Tc-MIBI was able to diagnose malignancy (true-positive). High-quality imaging with 99m Tc-MIBI has a high diagnostic accuracy for the detection of primary breast cancer. Used as a complementary method, scintimammography with 99m Tc-MIBI can help to diagnose breast cancer at an earlier stage in patients with dense breasts.

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Section: Histopathologymentioning

confidence: 99%

“…Use of fluorine-18 fluorodeoxyglucose ( 18 F-FDG) and positron emission tomography (PET) has also been evaluated for the detection of breast cancer [14][15][16][17][18][19][20][21]. In a larger patient group, Avril et al reported a sensitivity and specificity for the detection of primary breast cancer of 88% and 78%, respectively [18].…”

Section: Histopathologymentioning

confidence: 99%

Scintimammography with technetium-99m methoxyisobutylisonitrile: results of a prospective European multicentre trial

Palmedo

Biersack

Lastoria³

et al. 1998

European Journal of Nuclear Medicine and Molecular Imaging

108

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show abstract

“…Otto Warburg [1,2] first discovered that cancer cells displayed enhanced glucose uptake and aerobic glycolysis, a phenomenon often referred as the Warburg Effect nowadays. Although the mechanism underlying the Warburg Effect is still not fully understood, increased uptake of glucose provides the basis to exploit its clinical application by 18 F-deoxyglucose positron emission tomography (PET) for tumor detection [3,4]. Decades after the Warburg Effect was discovered, the mechanistic insights of how metabolic alterations contribute to tumorigenesis are just emerging.…”

mentioning

confidence: 99%

Metabolic alteration in tumorigenesis

Yang

Guan

2013

Sci. China Life Sci.

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Altered metabolism in cancer was first discovered by Otto Warburg early last century. Although the Warburg Effect has been widely used in tumor detection, relatively little progress had been made in mechanistic understanding of cancer metabolism in the subsequent eight decades. Genetic studies have recently identified mutations in human cancer targeting multiple enzymes involved in intermediate metabolism. One emerging mechanism common to these mutant enzymes is the accumulation of a metabolite that alters the epigenetic control. Otto Warburg [1,2] first discovered that cancer cells displayed enhanced glucose uptake and aerobic glycolysis, a phenomenon often referred as the Warburg Effect nowadays. Although the mechanism underlying the Warburg Effect is still not fully understood, increased uptake of glucose provides the basis to exploit its clinical application by 18 F-deoxyglucose positron emission tomography (PET) for tumor detection [3,4]. Decades after the Warburg Effect was discovered, the mechanistic insights of how metabolic alterations contribute to tumorigenesis are just emerging. Recent studies have revealed that eight metabolic genes, FH, SDHA, SDHB, SDHC, SDHD, SDHAF2, IDH1 and IDH2, encoding for subunits of four different metabolic enzymes, fumarate hydratase (FH), succinate dehydrogenase (SDH), and isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2), were mutated in a number of human cancers [5]. These findings provide compelling genetic evidence supporting the notion that altered metabolism contributes to, as opposed to the consequence of, tumorigenesis. Here, we first briefly discuss how metabolism is reprogrammed to support cancer cell proliferation. We then focus on one emerging mechanism that is common to the mutations targeting all four metabolic enzymes in accumulating a metabolite to alter the epigenetic modifications in human cancer.

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“…For this purpose, preoperative 18 F-fluorodeoxyglucose ( 18 F-FDG) positron emission tomography-computed tomography (PET-CT) is recommended in patients with breast cancer [2,3]. Although 18 F-FDG PET-CT has proved to be valuable for deciding appropriate treatment options, the degree of 18 F-FDG uptake, measured as maximum standardized uptake value (SUVmax), is diverse and highly versatile for evaluating the therapeutic effect and prognosis [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…In the clinical setting, the intensity of 18 F-FDG uptake of breast cancer with similar tumor size was diverse [4,[14][15][16][17][18], and there were some cases of small-sized breast cancer with relatively intense 18 F-FDG uptake. For this reason, this study was designed to investigate the relationship between clinicopathologic factors for prediction of the aggressiveness of the primary tumor and the intensity of 18 F-FDG in the relatively early T stage of breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Factors Associated with 18F-Fluorodeoxyglucose Uptake in T1 and T2 Invasive Ductal Carcinoma of the Breast

Kim

et al. 2016

Nucl Med Mol Imaging

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Purpose The objective of this study was to investigate the relationship between diversity of 18 F-fluorodeoxyglucose ( 18 F-FDG) uptake of primary tumor in positron emission tomography (PET) and various clinicopathologic factors in breast cancer of same pathologic T1, T2 stage. Methods A total of 258 patients with invasive ductal breast cancer were enrolled in this study. All patients underwent 18 F-FDG PET-CT before surgery. Patients were divided into two groups according to tumor size based on the pathologic T stage, and maximum standardized uptake value (SUVmax) of 2.5, respectively. Results On the univariate analysis, estrogen receptor (ER), tumor size, lymphovascular invasion, p53, pathologic N status (pN) and Nottingham tumor grade (NG) were associated with high SUVmax in T1 and T2 breast cancer. On the multivariate logistic regression, tumor size and NG remained significant variables dividing high and low SUVmax. In the T1 group, ER, p53 and NG were significantly associated with high SUVmax on the univariate analysis. In this group, p53 and NG remained significant variables for dividing high and low SUVmax on the multivariate logistic regression. In the T2 group, only NG was associated with high SUVmax on the univariate analysis.Conclusions NG showed an association with 18 F-FDG uptake in both T1 and T2 breast cancer independently; however, p53 in T1 breast cancer.

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Metabolic characterization of breast tumors with positron emission tomography using F-18 fluorodeoxyglucose.

Cited by 215 publications

References 22 publications

Scintimammography with technetium-99m methoxyisobutylisonitrile: results of a prospective European multicentre trial

Scintimammography with technetium-99m methoxyisobutylisonitrile: results of a prospective European multicentre trial

Metabolic alteration in tumorigenesis

Factors Associated with 18F-Fluorodeoxyglucose Uptake in T1 and T2 Invasive Ductal Carcinoma of the Breast

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