Metabolic Changes Induced in Elderly Patients With an Anabolic Steroid (Oxandrolone)

Gherondache, Constantin N.; Dowling, William J.; Pincus, Gregory

doi:10.1093/geronj/22.3.290

Cited by 15 publications

(6 citation statements)

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“…Moreover it is not yet known if the lipid lowering effects can be separated from the anaboric, androgenic or progestational activities of these compounds. Previous work by Furman, Howard and coworkers (39)(40)(41), Berkowitz et al (42), Sachs and Walfman (43), Gherondache (44), Skikantia (45), Cohen (46), and respective colleagues, suggests that many structurally related testosterone derivatives have similar triglyceride lowering effects in normal and hyperglyceridemic subjects. These testosterone and nortestosterone derivatives are primarily anaboric, androgenic, or both, and include the following: Methyltestosterone (41); Oxymeth-F1SHBACK AND P. STEINER elone (42) (2-hydroxy-methylene-17 amethyl-17/3 hydroxy-3-androstanone); Oxandrolone (43,44) (17r methyl-2-oxa-5a androstan-17/3 ol-3-one); Androstanopyrazole (40) (17/3 hydroxy-17c~ methyl-androstano-3, 2-c pyrazole); Methandrostenolone (45); Androsterone (46).…”

Section: Anabolic-androgenic Compounds and Triglyceridesmentioning

confidence: 95%

“…Norethindrone acetate is a 17 alkylated nortestosterone derivative which has potent progestational activity. Since similar androgenic-anabolic testosterone and nor-testosterone derivatives also lower triglycerides (39)(40)(41)(42)(43)(44)(45)(46), one important question to be resolved is whether all of these structurally related compounds alter plasma glycerides and triglyceride clearing enzymes by similar mechanisms. Moreover it is not yet known if the lipid lowering effects can be separated from the anaboric, androgenic or progestational activities of these compounds.…”

Section: Anabolic-androgenic Compounds and Triglyceridesmentioning

confidence: 99%

See 1 more Smart Citation

Progestagens, anabolic‐androgenic compounds, estrogens: Effects on triglycerides and postheraprin lipolytic enzymes

Glueck

Scheel

Fishback

et al. 1972

Lipids

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Section: Anabolic-androgenic Compounds and Triglyceridesmentioning

confidence: 95%

Section: Anabolic-androgenic Compounds and Triglyceridesmentioning

confidence: 99%

Progestagens, anabolic‐androgenic compounds, estrogens: Effects on triglycerides and postheraprin lipolytic enzymes

Glueck

Scheel

Fishback

et al. 1972

Lipids

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“…96 Several small clinical studies or cross-over trials of androgenic agents have not shown that they lead to weight gain. 95,97 Other pharmacologic approaches, such as anticytokine therapies, antileptin therapies and anti-inflammatory medications, are being investigated.…”

Section: Pharmacologic Therapy To Reverse Weight Lossmentioning

confidence: 99%

An approach to the management of unintentional weight loss in elderly people

Alibhai

Greenwood²,

Payette³

2005

Canadian Medical Association Journal

228

143

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UNINTENTIONAL WEIGHT LOSS, or the involuntary decline in total body weight over time, is common among elderly people who live at home. Weight loss in elderly people can have a deleterious effect on the ability to function and on quality of life and is associated with an increase in mortality over a 12-month period. A variety of physical, psychological and social conditions, along with age-related changes, can lead to weight loss, but there may be no identifiable cause in up to one-quarter of patients. We review the incidence and prevalence of weight loss in elderly patients, its impact on morbidity and mortality, the common causes of unintentional weight loss and a clinical approach to diagnosis. Screening tools to detect malnutrition are highlighted, and nonpharmacologic and pharmacologic strategies to minimize or reverse weight loss in older adults are discussed.

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“…Gherondache et al (1967) studied 24 geriatric patients with Bender visual-motor, gestalt and subsets of the Wechsler intelligence scale, and a counting test. There was significant (statistical) improvement in these parameters following steroid 463 administration.…”

Section: Neurologicalmentioning

confidence: 99%

“…There was significant (statistical) improvement in these parameters following steroid 463 administration. Despite these findings, anabolic steroids are not currently used to improve cognitive function in geriatric patients (Gherondache et al 1967).…”

Section: Neurologicalmentioning

confidence: 99%

Recent Developments in the Toxicology of Anabolic Steroids

Graham

Kennedy

1990

Drug Safety

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Anabolic steroids are extensively abused as ergogenic aids by athletes (and others). A number of features of anabolic steroid use and toxicology have been recently reviewed in the Journal, and a large body of data has accumulated concerning their toxic nature. The lipoprotein profile induced by anabolic steroids carries a markedly adverse cardiovascular risk. Glucose metabolism is significantly altered and includes peripheral insulin resistance, hyperinsulinaemia and attenuated responses to glucagon. Hypertension has been noted. Psychiatric and psychological alterations are major toxicities of anabolic steroids, and probably constitute the major mechanism of their action. Hepatic neoplasia occurs in the setting of abuse of this class of drugs, and may be related to their use, although there is no convincing evidence that other malignancies are induced in athletes who abuse them. Gross disturbance of reproductive function occurs in both sexes: hypogonadal states are common and prolonged. The anabolic steroids are toxic drugs with both long and short term effects. Their abuse by athletes is to be decried, particularly in view of the frequent and prolonged use by the young.

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Metabolic Changes Induced in Elderly Patients With an Anabolic Steroid (Oxandrolone)

Cited by 15 publications

References 0 publications

Progestagens, anabolic‐androgenic compounds, estrogens: Effects on triglycerides and postheraprin lipolytic enzymes

Progestagens, anabolic‐androgenic compounds, estrogens: Effects on triglycerides and postheraprin lipolytic enzymes

An approach to the management of unintentional weight loss in elderly people

Recent Developments in the Toxicology of Anabolic Steroids

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