Metabolic Changes in Trauma-Resistant Rats Following Trauma

Abstract

Some metabolites were followed in rats which had been made resistant to trauma by exposure to Noble–Collip drum injury. In trauma-resistant rats liver glycogen levels are 50% lower than in control animals. If trauma-resistant rats are subjected to trauma that does not kill control animals then the metabolic response during the first 2 hours after trauma, determined by measuring changes in blood glucose, pyruvic acid, amino nitrogen, urea, and total acetone bodies, differs from that of control animals only by being less pronounced quantitatively. The course of metabolic changes in trauma-resistant rats differs considerably from that of control animals between the 2nd and 24th hour after trauma, especially in the levels of acetone bodies and urea in the blood. The development of the resistance to trauma is accompanied by a change in the metabolic response to trauma.

The Effect of Age on the Ability of Rats to Adapt to Mechanical Trauma

“…It is known from a number of papers that both neurohumoral mechanisms, especially the pituitary-corticoadrenal system (Hruza and Chytil, 1959) and also changes in intermediary metabolism (Neufeld et ah, 1943;Chytil and …”

“…All other differences between individual groups are highly significant for P < 0.001. Hruza, 1958) and in the circulation ) play a part in the adaptation to the NCD. The role of connective tissue also can not be ignored.…”

ROUGH AND ROCKY ROAD TO THE RETINOID REVOLUTION

“…I was primarily collaborating with him on the metabolic consequences of the adaptation of rats to trauma. We published several papers in this area (10). While working at the Institute of Human Nutrition I did not run into any problems because of my political views, for the local Communist organization was very small and tolerant.…”