Metabolic changes in fibroblast-like synoviocytes in rheumatoid arthritis: state of the art review
Zhipeng Hu,
Yuan Li,
Lili Zhang
et al.
Abstract:Fibroblast-like synoviocytes (FLS) are important components of the synovial membrane. They can contribute to joint damage through crosstalk with inflammatory cells and direct actions on tissue damage pathways in rheumatoid arthritis (RA). Recent evidence suggests that, compared with FLS in normal synovial tissue, FLS in RA synovial tissue exhibits significant differences in metabolism. Recent metabolomic studies have demonstrated that metabolic changes, including those in glucose, lipid, and amino acid metabol… Show more
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