Metabolic Biomarkers in Aging and Anti-Aging Research

Guest, Paul C.

doi:10.1007/978-3-030-25650-0_13

Cited by 7 publications

(4 citation statements)

References 147 publications

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“…Aging, accompanied by the decline in health, independence, perceptual, cognitive, and decision-making abilities, is closely associated with the negative impacts of typical psychological stress [ 6 , 169 , 170 ]. Indeed, both psychological stress and aging show cumulative impact on most physiological systems [ 171 , 172 , 173 ] involving biological events at the molecular [ 173 ], cellular [ 174 ] and system [ 34 , 41 ] levels. Epigenetics alterations are triggered by the stressful or beneficial environmental input [ 175 ].…”

Section: Discussionmentioning

confidence: 99%

Fundamental Clock of Biological Aging: Convergence of Molecular, Neurodegenerative, Cognitive and Psychiatric Pathways: Non-Equilibrium Thermodynamics Meet Psychology

Dyakin

Dyakina-Fagnano

McIntire

et al. 2021

IJMS

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In humans, age-associated degrading changes, widely observed in molecular and cellular processes underly the time-dependent decline in spatial navigation, time perception, cognitive and psychological abilities, and memory. Cross-talk of biological, cognitive, and psychological clocks provides an integrative contribution to healthy and advanced aging. At the molecular level, genome, proteome, and lipidome instability are widely recognized as the primary causal factors in aging. We narrow attention to the roles of protein aging linked to prevalent amino acids chirality, enzymatic and spontaneous (non-enzymatic) post-translational modifications (PTMs SP), and non-equilibrium phase transitions. The homochirality of protein synthesis, resulting in the steady-state non-equilibrium condition of protein structure, makes them prone to multiple types of enzymatic and spontaneous PTMs, including racemization and isomerization. Spontaneous racemization leads to the loss of the balanced prevalent chirality. Advanced biological aging related to irreversible PTMs SP has been associated with the nontrivial interplay between somatic (molecular aging) and mental (psychological aging) health conditions. Through stress response systems (SRS), the environmental and psychological stressors contribute to the age-associated “collapse” of protein homochirality. The role of prevalent protein chirality and entropy of protein folding in biological aging is mainly overlooked. In a more generalized context, the time-dependent shift from enzymatic to the non-enzymatic transformation of biochirality might represent an important and yet underappreciated hallmark of aging. We provide the experimental arguments in support of the racemization theory of aging.

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Section: Discussionmentioning

confidence: 99%

Fundamental Clock of Biological Aging: Convergence of Molecular, Neurodegenerative, Cognitive and Psychiatric Pathways: Non-Equilibrium Thermodynamics Meet Psychology

Dyakin

Dyakina-Fagnano

McIntire

et al. 2021

IJMS

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“…Circulating biomarkers based on extracellular vesicles (EVs), including exosomes, microvesicles and apoptotic bodies, are moving into focus for the prediction of age-related diseases (Yáñez-Mó et al, 2015;Kalluri and LeBleu, 2020;Noren Hooten, 2020). Moreover, changes in the community composition of the skin microbiome have been related to age (Kim et al, 2019), and more precise information is obtained when considering the gut microbiome (Maynard and Weinkove, 2018;Guest, 2019;Askarova et al, 2020). In general, there is now ample evidence that microbiome dysbiosis is associated to aging and longevity (Kim and Benayoun, 2020).…”

Section: Non-epigenetic Research Laboratory Biomarkersmentioning

confidence: 99%

Ranking Biomarkers of Aging by Citation Profiling and Effort Scoring

Hartmann

Secci

et al. 2021

Front. Genet.

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Aging affects most living organisms and includes the processes that reduce health and survival. The chronological and the biological age of individuals can differ remarkably, and there is a lack of reliable biomarkers to monitor the consequences of aging. In this review we give an overview of commonly mentioned and frequently used potential aging-related biomarkers. We were interested in biomarkers of aging in general and in biomarkers related to cellular senescence in particular. To answer the question whether a biological feature is relevant as a potential biomarker of aging or senescence in the scientific community we used the PICO strategy known from evidence-based medicine. We introduced two scoring systems, aimed at reflecting biomarker relevance and measurement effort, which can be used to support study designs in both clinical and research settings.

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“…Çalışma sonuçları, literatürde belirtilen metilasyon değişimlerinin yaşla korele olduğu bilgisiyle uyumludur. 15 Ayrıca, hasta sayının sınırlı olması istatistiksel analizlerinin duyarlılığını azaltabilir. Hasta sayısının artırılarak benzer çalışmaların yapılması hâ-linde, bu yöntemin 5 alfa redüktaz Tip 2 enzim eksikliği ön tanısıyla takip edilen, değişik nedenlerle genital cilt fibroblast kültüründe enzim analizi yapılamayan ve DNA dizi analizinde mutasyon bulunamayan bu hastalarda metilasyon değişikliklerinin de değerlendirilmesinin hastalığın genetik etiyolojisinin aydınlatılmasında yararlı olacağı düşünülmektedir.…”

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Investigation of Methylation Alterations on SRD5A2 Gene in Patients with 5 Alpha Reductase Type 2 Enzyme Deficiency

Kırat¹,

Yiğin²,

Özdemir³

et al. 2020

Turkiye Klinikleri J Med Sci

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Tur ki ye Kli nik le ri J Med Sci. 2020;40(1): [68][69][70][71][72][73] 68 Cinsel gelişim bozuklukları (CGB); genetik, hormonal ve çevresel faktörlerin rol oynadığı, kromozomal yapı ile gonad ve dış genital organların birbirleriyle uyumsuzluk gösterdiği heterojen bir hastalık grubudur. 1 Klinik bulgular bireyler arasında ciddi farklılık göstermesine rağmen, hastalar genellikle yenidoğan döneminde ambigus genitalya ile tanınırlar. 2 'nda sözel olarak sunulmuştur.ÖZET Amaç: 5 alfa redüktaz Tip 2 enzim eksikliği; erkek genotipli (46,XY) bireylerde cinsel gelişim bozukluğuna neden olan, otozomal resesif kalıtılan bir hastalıktır. 5 alfa redüktaz Tip 2 enzim eksikliği düşünülen hastalarda en önemli tanı yöntemi genital cilt fibroblast kültürü enzim analizidir. Ancak, pratikte kesin tanı SRD5A2 (Steroid 5 alfa redüktaz alfa polipeptid 2) geni mutasyon analizi ile konulmaktadır. Klinik bulgular 5 alfa redüktaz Tip 2 enzim eksikliğini düşündürmesine rağmen, hastaların bir kısmında dizi analizi ile mutasyon tespit edilememektedir. Bu çalışmada, 5 alfa redüktaz Tip 2 enzim eksikliği ön tanısıyla izlenen ve SRD5A2 geninde dizi analizi ile mutasyon tespit edilmeyen hastalarda metilasyon değişikliklerinin incelenmesi ve mevcut hastalıkla metilasyon değişiklikleri arasında bir ilişki olup olmadığının belirlenmesi amaçlandı. Gereç ve Yöntemler: 5AR2E ön tanısı alan, 46,XY genotipine sahip, dış genital anomalisi olan, beta insan koryonik gonadotropini uyarısına normal testosteron yanıtı veren, testosteron/dihidrotestosteron oranı 8`in üzerinde tespit edilen ve SRD5A2 geninde mutasyon saptanmayan hastalar ile değişik nedenlerle polikliniğimize başvuran 12 sağlıklı ve gönüllü birey kontrol grubu olarak çalışmaya dâhil edildi. Bulgular: Hasta grubunun SRD5A2 genindeki 6 adet CpG adacığının metilasyon oranları, kontrol grubu ile karşılaştırıldığında daha yüksek bulundu ve DNA metilasyonunun SRD5A geninin düzenlenmesinde rol oynayabileceği gösterildi. Sonuç: Değişik nedenlerle genital cilt fibroblast kültüründe enzim analizi yapılamayan ve DNA dizi analizinde mutasyon bulunmayan bu hastalarda, metilasyon değişikliklerinin de değerlendirilmesinin hastalığın genetik etiyolojisinin aydınlatılmasında yararlı olacağı düşünülmektedir. Anah tar Ke li me ler: Cinsel gelişim bozukluğu;SRD5A2 geni; epigenetik ABS TRACT Objective: 5 alpha reductase Type 2 enzyme deficiency is an autosomal recessive inherited disease that causes sexual development disorder in individuals with male genotype (46,XY). Genital skin fibroblast culture enzyme analysis is the most important diagnostic method in patients with 5 alpha reductase Type 2 enzyme deficiency. However, definitive diagnosis is made by SRD5A2 (Steroid 5 alpha reductase alpha polypeptide 2) gene mutation analysis. Although clinical findings suggest 5 alpha reductase Type 2 enzyme deficiencies, mutation cannot be detected by sequence analysis in some patients. The aim of this study was to investigate the methylation changes in patients with a pre-diagnosis of 5 alpha reductase Type 2 enzyme deficie...

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Metabolic Biomarkers in Aging and Anti-Aging Research

Cited by 7 publications

References 147 publications

Fundamental Clock of Biological Aging: Convergence of Molecular, Neurodegenerative, Cognitive and Psychiatric Pathways: Non-Equilibrium Thermodynamics Meet Psychology

Fundamental Clock of Biological Aging: Convergence of Molecular, Neurodegenerative, Cognitive and Psychiatric Pathways: Non-Equilibrium Thermodynamics Meet Psychology

Ranking Biomarkers of Aging by Citation Profiling and Effort Scoring

Investigation of Methylation Alterations on SRD5A2 Gene in Patients with 5 Alpha Reductase Type 2 Enzyme Deficiency

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