Metabolic assessment of cerebral palsy with normal clinical MRI using 18F-FDG PET imaging: A preliminary report

Wu, Ruimin; Gao, Yan; Zhang, Huaqiong; Chen, Yijia; Fan, Timothy M.; Zeng, Daobing; Wan, Huabing; Yang, Yi; Gu, Jiaowei; Pei, Zhijun

doi:10.3389/fneur.2022.844911

Cited by 2 publications

(2 citation statements)

References 35 publications

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“…The authors did note a caveat that they did not analyze cerebellar tractography, which would certainly be interesting to examine. Another study from Wu et al built upon these findings, noting that in CP patients with normal MRIs there were functional impairments in glucose metabolism on FDG PET in several cortical regions, cerebellum, and the “central region” [ 49 ].…”

Section: Acquired Lesion-associated and Isolated Idiopathic Focal/seg...mentioning

confidence: 99%

Function and dysfunction of the dystonia network: an exploration of neural circuits that underlie the acquired and isolated dystonias

Gill,

Nguyen,

Hull

et al. 2023

Dystonia

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Dystonia is a highly prevalent movement disorder that can manifest at any time across the lifespan. An increasing number of investigations have tied this disorder to dysfunction of a broad “dystonia network” encompassing the cerebellum, thalamus, basal ganglia, and cortex. However, pinpointing how dysfunction of the various anatomic components of the network produces the wide variety of dystonia presentations across etiologies remains a difficult problem. In this review, a discussion of functional network findings in non-mendelian etiologies of dystonia is undertaken. Initially acquired etiologies of dystonia and how lesion location leads to alterations in network function are explored, first through an examination of cerebral palsy, in which early brain injury may lead to dystonic/dyskinetic forms of the movement disorder. The discussion of acquired etiologies then continues with an evaluation of the literature covering dystonia resulting from focal lesions followed by the isolated focal dystonias, both idiopathic and task dependent. Next, how the dystonia network responds to therapeutic interventions, from the “geste antagoniste” or “sensory trick” to botulinum toxin and deep brain stimulation, is covered with an eye towards finding similarities in network responses with effective treatment. Finally, an examination of how focal network disruptions in mouse models has informed our understanding of the circuits involved in dystonia is provided. Together, this article aims to offer a synthesis of the literature examining dystonia from the perspective of brain networks and it provides grounding for the perspective of dystonia as disorder of network function.

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Section: Acquired Lesion-associated and Isolated Idiopathic Focal/seg...mentioning

confidence: 99%

Function and dysfunction of the dystonia network: an exploration of neural circuits that underlie the acquired and isolated dystonias

Gill,

Nguyen,

Hull

et al. 2023

Dystonia

View full text Add to dashboard Cite

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“…However, after 70 years of development, the main principle of PET scanners of recording electron-positron annihilation into two photons and its applications based on localizing the accumulation of pharmaceuticals remained unchanged. For example, PET scans of the brain are mainly performed to locate lesions, including determining the location and size of brain tumors [19], to assess the measurement of cellular and tissue metabolism, to show blood flow, to evaluate patients with seizure disorders (epilepsy) who do not respond to pharmacotherapy [20], and patients with memory impairment due to neurodegenerative diseases (Alzheimer’s disease spectrum and Parkinson’s disease [21]). The detection of molecular alterations which is not currently achievable would be possible using positronium imaging, which would increase PET specificity for early recognition of these diseases before the functional changes occur [1].…”

Section: Introductionmentioning

confidence: 99%

First positronium image of the human brainin vivo

Moskal,

Baran,

Bass

et al. 2024

Preprint

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Positronium, an unstable atom consisting of an electron and a positron, is abundantly produced within the molecular voids of a patient's body during positron emission tomography (PET) diagnosis. Its properties, such as its average lifetime between formation and annihilation into photons, dynamically respond to the submolecular architecture of the tissue and the partial pressure of oxygen molecules. However, the diagnostic information that positronium may deliver about early molecular alterations remains unavailable in clinics with state-of-the-art PET scanners. This study presents the first in vivo images of positronium lifetime in humans. We developed a dedicated J-PET system with multiphoton detection capability for imaging. The measurements of positronium lifetime were performed on a patient with a glioblastoma tumor in the brain. The patient was injected intratumorally with the68Ga radionuclide attached to Substance-P, which accumulates in glioma cells, and intravenously with68Ga attached to the PSMA-11 ligand, which is selective to glioma cells and salivary glands. The 68Ga radionuclide is routinely used in PET for detecting radiopharmaceutical accumulation and was applied for positronium imaging because it can emit an additional prompt gamma. The prompt gamma enables the determination of the time of positronium formation, while the photons from positronium annihilation were used to reconstruct the place and time of its decay. The determined positronium mean lifetime in glioblastoma cells is shorter than in salivary glands, which in turn is shorter than in healthy brain tissues, demonstrating for the first time that positronium imaging can be used to diagnose disease in vivo. This study also demonstrates that if current total-body PET systems were equipped with multiphoton detection capability and the44Sc radionuclide was applied, it would be possible to perform positronium imaging at 6500 times greater sensitivity than achieved in this research. Therefore, it is anticipated that positronium imaging has the potential to bring a new quality of cancer diagnosis in clinics.

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Metabolic assessment of cerebral palsy with normal clinical MRI using 18F-FDG PET imaging: A preliminary report

Cited by 2 publications

References 35 publications

Function and dysfunction of the dystonia network: an exploration of neural circuits that underlie the acquired and isolated dystonias

Function and dysfunction of the dystonia network: an exploration of neural circuits that underlie the acquired and isolated dystonias

First positronium image of the human brainin vivo

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