Metabolic Aspects of Desert Adaptation (Man)

Samueloff, S.

doi:10.1016/b978-0-12-027307-2.50009-8

Cited by 3 publications

(2 citation statements)

References 171 publications

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“…However, the mechanisms and factors contributing to heat intolerance are largely unknown and understudied. Early studies in the field of exercise physiology allude to a role of increased glycolysis and decreased lipid metabolism in heat intolerant individuals [16], where relative workload demands (oxygen consumption) are reduced in heat tolerant individuals during acute heat exposure [17]. Aside from these studies, animal studies point to genetic influences [18, 19].…”

Section: Introductionmentioning

confidence: 99%

The impact of heat stress on the human plasma lipidome

Estevao,

Kazman,

Bramer

et al. 2024

Preprint

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The year of 2023 displayed the highest average global temperatures since it has been recorded—the duration and severity of extreme heat are projected to increase. Rising global temperatures represent a major public health threat, especially to occupations exposed to hot environments, such as construction and agricultural workers, and first responders. Despite efforts of the scientific community, there is still a need to characterize the pathophysiological processes leading to heat related illness and develop biomarkers that can predict its onset. Here, we performed a plasma lipidomic analysis on male and female subjects who underwent heat tolerance testing (HTT), consisting of a 2-h treadmill walk at 5 km/h with 2% inclination at a controlled temperature of 40°C. We identified 995 lipids from 27 classes, with nearly half of all detected lipids being responsive to HTT. Lipid classes related to substrate utilization were predominantly affected by HTT, with a downregulation of triacylglycerols and upregulation of free fatty acids and acyl-carnitines (CARs). We additionally examined correlations between changes in plasma lipids by using the physiological strain index (PSI). Here, even chain CAR 4:0, 14:0 and 16:1, suggested by-products of incomplete beta oxidation, and diacylglycerols displayed the highest correlation to PSI. PSI did not correlate with plasma lactate levels, suggesting that correlations between even chain CARs and PSI is related to metabolic efficiency versus physical exertion. Overall, our results show that HTT has a strong impact on the plasma lipidome and that metabolic inefficiencies may underlie heat intolerance.

show abstract

Section: Introductionmentioning

confidence: 99%

The impact of heat stress on the human plasma lipidome

Estevao,

Kazman,

Bramer

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…However, the mechanisms and factors contributing to heat intolerance are largely unknown and understudied. Early studies in the eld of exercise physiology allude to a role of increased glycolysis and decreased lipid metabolism in heat intolerant individuals [16], where relative workload demands (oxygen consumption) are reduced in heat tolerant individuals during acute heat exposure [17]. Aside from these studies, animal studies point to genetic in uences [18,19].…”

mentioning

confidence: 99%

The impact of heat stress on the human plasma lipidome

Estevao,

Kazman,

Bramer

et al. 2024

Preprint

View full text Add to dashboard Cite

The year of 2023 displayed the highest average global temperatures since it has been recorded—the duration and severity of extreme heat are projected to increase. Rising global temperatures represent a major public health threat, especially to occupations exposed to hot environments, such as construction and agricultural workers, and first responders. Despite efforts of the scientific community, there is still a need to characterize the pathophysiological processes leading to heat related illness and develop biomarkers that can predict its onset. Here, we performed a plasma lipidomic analysis on male and female subjects who underwent heat tolerance testing (HTT), consisting of a 2-h treadmill walk at 5 km/h with 2% inclination at a controlled temperature of 40ºC. We identified 995 lipids from 27 classes, with nearly half of all detected lipids being responsive to HTT. Lipid classes related to substrate utilization were predominantly affected by HTT, with a downregulation of triacylglycerols and upregulation of free fatty acids and acyl-carnitines (CARs). We additionally examined correlations between changes in plasma lipids by using the physiological strain index (PSI). Here, even chain CAR 4:0, 14:0 and 16:1, suggested by-products of incomplete beta oxidation, and diacylglycerols displayed the highest correlation to PSI. PSI did not correlate with plasma lactate levels, suggesting that correlations between even chain CARs and PSI is related to metabolic efficiency versus physical exertion. Overall, our results show that HTT has a strong impact on the plasma lipidome and that metabolic inefficiencies may underlie heat intolerance.

show abstract

Osmotic and Ionic Regulation in Mammals

Kinne¹,

Zeidel²

2008

Osmotic and Ionic Regulation

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Metabolic Aspects of Desert Adaptation (Man)

Cited by 3 publications

References 171 publications

The impact of heat stress on the human plasma lipidome

The impact of heat stress on the human plasma lipidome

The impact of heat stress on the human plasma lipidome

Osmotic and Ionic Regulation in Mammals

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