Metabolic Approaches to Cancer Cachexia

Lawson, David H.; Richmond, Ann; Nixon, Daniel W.; Rudman, Daniel

doi:10.1146/annurev.nu.02.070182.001425

Cited by 145 publications

(46 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The loss of body weight and development of cachexia are common and easily recognisable signs that are associated with cancer and several other chronic and inflammatory diseases (Lawson et al, 1982). In response to neoplastic and infectious diseases, a variety of cells, including macrophages and lymphocytes, secrete cytokines which are capable of altering the host's metabolism.…”

Section: Discussionmentioning

confidence: 99%

Bioactivity of skeletal muscle proteolysis-inducing factors in the plasma proteins from cancer patients with weight loss

Belizário

Katz²,

Chenker³

et al. 1991

Br J Cancer

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Bioactivity of skeletal muscle proteolysis-inducing factors in the plasma proteins from cancer patients with weight loss

Belizário

Katz²,

Chenker³

et al. 1991

Br J Cancer

View full text Add to dashboard Cite

show abstract

“…Cachexia is a poorly understood syndrome characterized by anorexia, profound metabolic abnormalities, and progressive host wasting that results in death ( [1][2][3]. Tissue wasting mainly involves skeletal muscles and adipose tissue.…”

Section: Introductionmentioning

confidence: 99%

Tumor necrosis factor-alpha mediates changes in tissue protein turnover in a rat cancer cachexia model.

Costelli¹,

Carbó²,

Tessitore³

et al. 1993

J. Clin. Invest.

280

156

View full text Add to dashboard Cite

Rats bearing the Yoshida AH-130 ascites hepatoma showed enhanced fractional rates of protein degradation in gastrocnemius muscle, heart, and liver, while fractional synthesis rates were similar to those in non-tumor bearing rats. This hypercatabolic pattern was associated with marked perturbations of the hormonal homeostasis and presence of tumor necrosis factor in the circulation.The daily administration of a goat anti-murine TNF IgG to tumor-bearing rats decreased protein degradation rates in skeletal muscle, heart, and liver as compared with tumor-bearing rats receiving a nonimmune goat IgG. The anti-TNF treatment was also effective in attenuating early perturbations in insulin and corticosterone homeostasis. Although these results suggest that tumor necrosis factor plays a significant role in mediating the changes in protein turnover and hormone levels elicited by tumor growth, the inability of such treatment to prevent a reduction in body weight implies that other mediators or tumorrelated events were also involved. (J. Clin. Invest. 1993.

show abstract

“…The loss of body weight and development of cachexla are common signs associated with neoplastlc diseases Cachexia 1s a poorly understood syndrome characterized by anorexia, weight loss, profound metabolic abnormalities and progressive host wasting which may result m death [32,47,51]. Tissue wasting mvolves mainly adipose tissue and skeletal muscle Numerous reports attribute the cachectlc state of the host to cytokmes released as a result of mvaslve stlmuh (see [ 151 for review).…”

Section: Introductionmentioning

confidence: 99%

Ubiquitin gene expression is increased in skeletal muscle of tumour‐bearing rats

et al. 1994

View full text Add to dashboard Cite

Rats bearmg the fast-growmg AH-l 30 Yoslnda ascItes hepatoma showed a marked cachectlc response which has been previously reported [Tessltore et al (1987) Blochem J 241, 153-1591 Thus tumour-bearmg ammals showed slgmficant decreases m body and muscle weight (soleus and gastrocnemms) as compared to both pair-fed and ad hbltum-fed animals These decreases were related to an enhanced proteolytlc rate m the muscles of the tumour-bearmg ammals as measured by the tyrosme released m m vitro assays In an attempt to elucidate which proteolytlc system IS directly responsible for the decrease m muscle mass, we have studied both lysosomal and non-lysosomal (ATP-dependent) proteolytlc systems m this animal model While the enzymatic activities of the mam cathepsm (B and B + L.) systems were actually decreased m gastrocnemms muscles of tumourbearmg rats, thus mdicatmg that lysosomal proteolysls was not involved, the ublqmtm pools (both free and conjugated) were markedly altered as a result of tumour burden These were associated with an increased ublqmtm gene expression m muscle of tumour-beanng rats, over 500% m relation to non-twnour bearers, thus suggesting that the ATP-dependent proteolytlc system may be responsible for the muscle proteolysls and wastage observed m this animal tumour model The fact that we have previously shown that TNF enhances the ublqultmlzation of muscle proteins FEBS Lett 323, 21 l-2141, together with the high clrculatmg levels of TNF detected m rats bearmg the Yoshlda hepatoma allows us to suggest that the cytokme may be responsible, most probably mdlrectly, for the activation of the referred proteolytlc system m tumour-bearing rats

show abstract

Metabolic Approaches to Cancer Cachexia

Cited by 145 publications

References 74 publications

Bioactivity of skeletal muscle proteolysis-inducing factors in the plasma proteins from cancer patients with weight loss

Bioactivity of skeletal muscle proteolysis-inducing factors in the plasma proteins from cancer patients with weight loss

Tumor necrosis factor-alpha mediates changes in tissue protein turnover in a rat cancer cachexia model.

Ubiquitin gene expression is increased in skeletal muscle of tumour‐bearing rats

Contact Info

Product

Resources

About