Metabolic and structural abnormalities in dogs with early left ventricular dysfunction induced by incessant tachycardia

Abstract

Results indicated that moderate to severe alterations in myocyte cytoarchitecture are present in dogs with ELVD induced by RRVP and that in dogs with normal plasma carnitine concentrations, myocardial carnitine deficiency may be a biochemical marker of ELVD. Results also indicated that transvenous endomyocardial biopsy can be used to evaluate biochemical and structural myocardial changes in dogs with cardiac disease.

Evaluation of cardiac lesions and risk factors associated with myocarditis and dilated cardiomyopathy in southern sea otters (Enhydra lutris nereis)

“…v Experimentally induced persistent tachycardia in dogs also caused primary myocardial carnitine depletion and an increase in serum carnitine concentrations. 77,78 Thus, it is possible that domoic acid exposure in sea otters causes overstimulation of glutamate receptors in the CNS and myocardium, causing tachycardia and subsequent myocardial carnitine depletion. Unfortunately, past domoic acid exposure status was known for only 5 otters with measured myocardial carnitine concentration; therefore, sample sizes were too small to directly test the association between suspected domoic acid exposure and myocardial carnitine concentration.…”

Right atrial and right ventricular ultrasound‐guided biopsy technique in standing horses

“…Serial endomyocardial biopsies can also be used for research purposes. Endomyocardial biopsies were used to demonstrate alterations in myocyte cytoarchitecture in a dog model for dilated cardiomyopathy . Post mortem examination demonstrated insignificant changes at the biopsy site after repeated endomyocardial biopsies in dogs .…”

Vorhofflimmern als prognostischer Faktor bei der dilatativen Kardiomyopathie des Dobermanns im kongestiven Herzversagen

“…Aktuell wird außerdem ein Zusammenhang zwischen getreidefreier Fütterung und der Entstehung einer DCM diskutiert (FREEMAN et al, 2018;ADIN et al, 2019;MANSILLA et al, 2019). Zudem kann eine DCM auch durch eine Tachykardie, durch ein infektiöses Geschehen oder durch Medikamente, wie beispielsweise Doxorubicin, oder Toxine induziert werden (MC ENTEE et al, 2001;TIDHOLM et al, 2001;HALLMAN et al, 2019).…”