Metabolic and Hypertensive Complications of Pregnancy in Women with Nephrolithiasis

Powe, Camille E.; Ecker, Jeffrey L.; Bramham, Kate; Ankers, Elizabeth; Karumanchi, S. Ananth; Thadhani, Ravi

doi:10.2215/cjn.12171017

Cited by 18 publications

(8 citation statements)

References 42 publications

(39 reference statements)

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“…In the case of instrumental and laboratory studies, against the control group's reference values, at animals of the experimental group there was a hypertension (141/85±5) mm Hg, dyslipidemia (total cholesterol level (5.37±0.33) mmol/L, TG (2.55± 0.24) mmol/L), elevated glucose (8.52±0.17) mmol/L. Some studies have indicated that the most common combination of metabolic syndrome is the combination of obesity, arterial hypertension, hypercholesterolemia and insulin resistance [14,15]. Taking into account the morphometric, instrumental and laboratory parameters of experimental group rats, there are grounds to assert that the used model for introduction into the metabolic syndrome is effective, and females are in a metabolic syndrome.…”

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confidence: 99%

Morphometric, Instrumental and Laboratory Parameters of Female Rats With Experimental Metabolic Syndrome

Hrygorieva

Korotchuk

2020

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The aim of the study – to learn the dynamics of changes of morphometric, instrumental and laboratory parameters in mature females rats with experimental metabolic syndrome. Material and Methods. 20 females of white, mature laboratory rats, aged 18–20 months were divided into 2 groups. The first one is an experimental group: 13 female rats with experimental metabolic syndrome; the second one – control group: 7 intact rats, with standard food and water regime. When working with animals, the standards of the Council of Europe Bioethics Convention 1997, the European Convention for the Protection of Vertebrate Animals were observed. Instruments used during scientific research were subject to metrological control. The simulation of the metabolic syndrome occurred during 60 days. The females supported a special high-calorie diet (grain with margarine 82 % milk fat, corn and sunflower seeds). The water regime included a 20 % solution of fructose and regular water ad libitum, with change every other day. Also, during the first and the fourth weeks of the experiment, the female daily subcutaneously administered Dexamethasone solution at a dosage of 0.1 mg/kg. Results. Since the beginning of the experiment, female rats who received a special high-calorie diet showed a statistically significant increase in all morphometric and instrumental indexes compared to similar rats in the control group. An increase in body weight in the experimental group was found to be 28.93 % higher than the original weight, was observed arterial hypertension (141/85±5) mmHg, dyslipidemia: elevated total cholesterol (5.37±0.33) mmol/L and TG (2.55±0.24) mmol/L; elevated level glucose (8.52±0.17) mmol/L. The above indicators are criteria indicating the presence of metabolic syndrome in animals under study. Conclusions. The proposed model of experimental metabolic syndrome, which includes subcutaneous administration of Dexamethasone solution at a dosage of 0.1 mg/kg in the first and the fourth weeks of experiment, with a special high calorie diet and a 20 % solution of fructose, is an effective way to reproduce the metabolic syndrome in small rodents.

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confidence: 99%

Morphometric, Instrumental and Laboratory Parameters of Female Rats With Experimental Metabolic Syndrome

Hrygorieva

Korotchuk

2020

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“…Results from our study are consistent with those from a previous follow-up study indicating that the risk of cardiovascular disease associated with GDM was not fully dependent upon the development of type 2 diabetes ( 23 ). In addition, a retrospective cohort study showed that a history of nephrolithiasis was associated with higher risks of GDM [OR (95% CI): 3.1 (1.8–5.3)] and preeclampsia [2.2 (1.3–3.6)], suggesting that stone formation is a marker of metabolic diseases and supporting the link between GDM and kidney stones ( 24 ).…”

Section: Discussionmentioning

confidence: 94%

Association Between Gestational Diabetes Mellitus and Future Risk of Kidney Stones

Mao

Hu²,

Liu

et al. 2022

Front. Public Health

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ObjectiveThe association between history of gestational diabetes mellitus (GDM) and risk of kidney stones has not been reported. GDM increases the risk of long-term complications including diabetes, hypertension and metabolic syndrome, which are risk factors of kidney stones. This study aimed to explore the association between previous GDM and odds of kidney stones.MethodsWomen (age ≥ 20 years) who had delivered at least one live birth were included from the 2007–2018 National Health and Nutrition Examination Survey cohort (N = 12,003). Patients with kidney stones and history of GDM were identified by in-home interview for all participants. Subgroup analyses were conducted by age, race/ethnicity, postpartum duration and status of hypertension, obesity, current diabetes and metabolic syndrome.ResultsPrevious GDM was positively associated with odds of kidney stones [multivariate-adjusted odds ratio (95% confidence interval): 1.41 (1.13–1.77)], and the association was stronger with odds of passing 2 or more times of kidney stones [1.72 (1.31–2.26)]. In subgroup analyses, the association between previous GDM and odds of kidney stones was significant in women within 15 years of a pregnancy complicated by GDM [1.54 (1.12–2.11)], in obese participants [1.56 (1.18–2.06)], in women without hypertension [1.49 (1.07–2.08)], current diabetes [1.38 (1.02–1.87)] and metabolic syndrome [1.56 (1.10–2.19)], in women of Non-Hispanic White [1.59 (1.15–2.18)] and in women aged more than 50 year [1.45 (1.02–2.07)].ConclusionsPrevious GDM was positively associated with odds of kidney stones, and the association was independent of type 2 diabetes, hypertension and metabolic syndrome.

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“…Of note, some studies including the HUNT II study, and a American matched cohort study of 778 women both recently failed to demonstrate an association between CKD and preeclampsia [5,10]. An association between prior history of kidney stones [13] or acute kidney injury that recovers [25] and pregnancy hypertension has also been described, suggesting there may be common maternal factors predisposing to kidney disorders and responses in pregnancy.…”

Section: Discussionmentioning

confidence: 99%

“…Outcomes for Australian women who had pregnancies while receiving dialysis or after transplantation have previously been explored [7][8][9]. Less is known about the prevalence and impact of earlier stages of chronic kidney impairment [2,10] and transient pathologies such as pyelonephritis and urological disorders [11][12][13]. Our knowledge is also hampered by the lack of routine kidney function testing in pregnancy.…”

Section: Introductionmentioning

confidence: 99%

The Spectrum of Adverse Pregnancy Outcomes Based on Kidney Disease Diagnoses: A 20-Year Population Study

et al. 2019

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Background and Objectives: Kidney disorders in pregnancy may be under-recognized and have variable impact on outcomes depending on diagnosis. Population-level data are limited, particularly for Australia, and comparison of impact of different kidney disorders on pregnancy has rarely been assessed. This study examined the prevalence and outcomes of varied kidney disorders using population-level perinatal data from a large cohort. Methods: Women with singleton pregnancies > 20 weeks’ gestation from the South Australian Pregnancy Outcomes Unit (1990–2012). Women with a kidney disorders diagnostic code were grouped into categories (immunological, cystic/genetic, urological, vesicoureteral reflux (VUR), pyelonephritis and “other”). Key pregnancy outcomes were assessed, with adjustment for demographic variables. Results: Kidney disorders were reported in 1,392 (0.3%) of 407,580 births. These pregnancies had increased risk of pregnancy-induced hypertension (OR 2.16, 95% CI 1.82–2.56), induction of labor (RRR vs. spontaneous birth 2.10, 95% CI 1.87–2.36), all Caesarean section (OR 1.31, 95% CI 1.17–1.47) as well as Caesarean section without labor (RRR 1.82, 95% CI 1.57–2.10), preterm birth (< 37 weeks; 2.76, 95% CI 2.40–3.18), low birth weight (< 2,500 g) infants (OR 2.43, 95% CI 2.07–2.84), and neonatal intensive care admission (OR 2.64, 95% CI 2.12–3.29). Diagnostic subgroups demonstrated differing patterns of adverse outcomes, enabling the development of a matrix of risk. Women with immunological renal conditions and VUR had greatest risk overall, and only women with immunological diseases had increased risk of small-for-gestational age < 10th centile (OR 2.36, 95% CI 1.26–4.42). Women with nonchronic urological conditions and pyelonephritis had increased risk of preterm birth, but not other adverse events. VUR conferred particularly increased risk of Caesarean section and induced labor. Conclusions: In a cohort of > 1,300 women with varied kidney disorders, increased adverse obstetric and perinatal events were observed, and the nature and magnitude of risk differed according to diagnosis. In particular, vesicoureteric reflux is not a benign condition in pregnancy. Women with nonchronic conditions still had increased risk of preterm birth. We confirm that women with kidney disorders warrant vigilant and tailored prepregnancy care and clinical care in pregnancy.

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Metabolic and Hypertensive Complications of Pregnancy in Women with Nephrolithiasis

Abstract: In women without preexisting diabetes, hypertension, and CKD, a history of nephrolithiasis was associated with gestational diabetes and hypertensive disorders of pregnancy, especially in women with high first trimester body mass index.

Cited by 18 publications

References 42 publications

Morphometric, Instrumental and Laboratory Parameters of Female Rats With Experimental Metabolic Syndrome

Morphometric, Instrumental and Laboratory Parameters of Female Rats With Experimental Metabolic Syndrome

Association Between Gestational Diabetes Mellitus and Future Risk of Kidney Stones

The Spectrum of Adverse Pregnancy Outcomes Based on Kidney Disease Diagnoses: A 20-Year Population Study

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