Metabolic and growth inhibitory effects of conjugated fatty acids in the cell line HT-29 with special regard to the conversion of t11,t13-CLA

Degen, Christian; Ecker, Josef; Piegholdt, Stefanie; Liebisch, Gerhard; Schmitz, Gerd; Jahreis, Gerhard

doi:10.1016/j.bbalip.2011.08.005

Cited by 40 publications

(31 citation statements)

References 48 publications

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“…Chin et al have demonstrated that CLA is produced in conventional but not in germ-free rats fed with free LA [39]. Mentionable, numerous studies have shown that the different isomers of CLA exhibit chemopreventive and anticarcinogenic effects regarding CRC in vitro, e.g., by inhibiting growth of colon cancer cells, as shown for HT29 cells [19,20] or LT97 colon adenoma cells [21]. t10,c12 CLA inhibits the growth of colon cancer cells by induction of reactive oxygen species-mediated stress in the endoplasmic reticulum Results were obtained from n = 5 fermentation samples of blank and Synergy1 ® , respectively, and n = 6 fermentation samples of each nut variety (one raw and five different roasting conditions) [40].…”

Section: Discussionmentioning

confidence: 96%

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In vitro fermentation of nuts results in the formation of butyrate and c9,t11 conjugated linoleic acid as chemopreventive metabolites

et al. 2015

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This is the first study that demonstrates the ability of the human fecal microbiota to convert polyunsaturated fatty acids from walnuts to c9,t11 CLA as a potential chemopreventive metabolite. In addition, the production of butyrate and reduction in potential carcinogens such as secondary BA and lipid peroxidation products might contribute to the protective effects of nuts regarding colon cancer development.

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Section: Discussionmentioning

confidence: 96%

“…CLA are isomers of LA with conjugated double bonds in trans and cis configurations which are converted, for example, from LA via the biohydrogenation process. CLA isomers exert chemopreventive effects by inhibiting the growth of colon cancer [19,20] and adenoma cells [21].…”

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confidence: 99%

In vitro fermentation of nuts results in the formation of butyrate and c9,t11 conjugated linoleic acid as chemopreventive metabolites

et al. 2015

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“…There is considerable interest in these rumen derived ALA-BHP as other CLnA isomers have been found to have stronger anticarcinogenic effects when compared to CLA [31][32]. Contents of CLnA isomers can be enhanced in ruminant products when combining forage-based diets with flaxseed [3,22,33].…”

Section: Isolation Of 18:3 Isomersmentioning

confidence: 96%

Isolation of α-linolenic acid biohydrogenation products by combined silver ion solid phase extraction and semi-preparative high performance liquid chromatography

Turner¹,

Meadus²,

Mapiye³

et al. 2015

Journal of Chromatography B

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“…The TFAs are stored in adipocytes and incorporated into membrane lipids. However, both cell culture and animal studies show that the various TFA are metabolized and converted via differing processes, and, also act in a biochemically different manner (Degen et al 2011a;Chardigny et al 2007, Kadegowda et al 2010. For example, trans isomers with a double bond in position 9 and 10 are not substrates for Δ9-desaturase.…”

Section: Differences In the Metabolismmentioning

confidence: 97%

Evaluation of the Impact of RuminantTransFatty Acids on Human Health: Important Aspects to Consider

Kuhnt

Degen

Jahreis

2015

Critical Reviews in Food Science and Nutrition

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The definition and evaluation of trans fatty acids (TFA) with regard to foodstuffs and health hazard are not consistent. Based on the current situation, the term should be restricted only to TFA with isolated double bonds in trans-configuration. Conjugated linoleic acids (CLA) should be separately assessed. Ideally, the origin of the consumed fat should be declared, i.e., ruminant TFA (R-TFA) and industrial TFA (non-ruminant; I-TFA). In ruminant fat, more than 50% of R-TFA consists of vaccenic acid (C18:1 t11). In addition, natural CLA, i.e., c9,t11 CLA is also present. Both are elevated in products from organic farming. In contrast to elaidic acid (t9) and t10, which occur mainly in partially hydrogenated industrial fat, t11 is partially metabolized into c9,t11 CLA via Δ9-desaturation. This is the major metabolic criterion used to differentiate between t11 and other trans C18:1. t11 indicates health beneficial effects in several studies. Moreover, CLA in milk fat is associated with the prevention of allergy and asthma. An analysis of the few studies relating to R-TFA alone makes clear that no convincing adverse physiological effect can be attributed to R-TFA. Only extremely high R-TFA intakes cause negative change in blood lipids. In conclusion, in most European countries, the intake of R-TFA is assessed as being low to moderate. Restriction of R-TFA would unjustifiably represent a disadvantage for organic farming of milk.

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Metabolic and growth inhibitory effects of conjugated fatty acids in the cell line HT-29 with special regard to the conversion of t11,t13-CLA

Cited by 40 publications

References 48 publications

In vitro fermentation of nuts results in the formation of butyrate and c9,t11 conjugated linoleic acid as chemopreventive metabolites

In vitro fermentation of nuts results in the formation of butyrate and c9,t11 conjugated linoleic acid as chemopreventive metabolites

Isolation of α-linolenic acid biohydrogenation products by combined silver ion solid phase extraction and semi-preparative high performance liquid chromatography

Evaluation of the Impact of RuminantTransFatty Acids on Human Health: Important Aspects to Consider

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