Metabolic and Functional Results After Laparoscopic Colorectal Surgery

Braga, Marco; Vignali, Andrea; Zuliani, Walter; Radaelli, Giovanni; Gianotti, Luca; Martani, C.; Toussoun, G.; Carlo, V. Di

doi:10.1007/s10350-004-6362-2

Cited by 124 publications

(78 citation statements)

References 34 publications

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“…Previous studies demonstrated that T helper cells decreased and T suppressor cells increased significantly as early as 1 day after surgery [22][23][24] . Many subsequent studies also confirmed that surgery for patients with lung cancer [25] , esophageal cancer [26] , gastric cancer [27,28] and colorectal cancer [29,30] induced immediate severe immunosuppression. For cancer patients, an important function adversely affected by this immunosuppression is the anti-tumor response itself.…”

Section: Discussionmentioning

confidence: 85%

Perioperative cimetidine administration promotes peripheral blood lymphocytes and tumor infiltrating lymphocytes in patients with gastrointestinal cancer: Results of a randomized controlled clinical trial

Cai¹,

Bai²,

Yuan³

et al. 2004

WJG

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AIM:To study the effects of perioperative administration of cimetidine (CIM) on peripheral blood lymphocytes, natural killer (NK) cells and tumor infiltrating lymphocytes (TIL) in patients with gastrointestinal (GI) cancer. METHODS:Forty-nine GI cancer patients were randomized into treatment group, who took CIM in perioperative period, and control group, who did not take the drug. The treatment was initiated 7 days before operation and continued for 10 days after surgery. At baseline examination before operation, on the 2nd and 10th postoperative days, total T lymphocytes, T helper cells, T suppressor cells, and NK cells in peripheral blood were measured respectively by immunocytochemical method using mouse-anti human CD 3 , CD 4 , CD 8 and CD 57 monoclonal antibodies. Blood samples from 20 healthy volunteers were treated in the same way as normal controls. Surgical specimens were examined during routine histopathological evaluation for the presence of TIL in tumor margin. Immunohistochemical study was performed to measure the proportion of T and B lymphocytes in TIL population. T and B lymphocytes were detected respectively using mouse-anti-human CD 3 and CD 20 monoclonal antibodies. RESULTS:In comparison with normal controls, both the treatment and control groups had decreased T cells, T helper cells and NK cells at baseline. In control group, total T cells, T helper cells and NK cells declined continuously with the disease progression and the decrease became more obvious after operation. From baseline to the 2nd postoperative day, the proportion of total T cells, T helper cells, and NK cells went down from 60.5±4.6% to 56.2±3.8%, 33.4±3.7% to 28.1±3.4%, and 15.0±2.8% to 14.2±2.2%, respectively. On the other hand, there were significant improvements in these parameters after CIM treatment. On the 10th postoperative day, the treatment group had significantly higher percentages of total T cells, T helper cells and NK cells than control group. Moreover, CIM treatment also boosted TIL response, as was reflected by findings that 68% (17/25) of the patients in treatment group had significant TIL responses and only 25% (6/24) of the cases had discernible TIL responses (P<0.01). CONCLUSION:Perioperative application of CIM to GI cancer patients could help restore the diminished cellular immunity induced by tumor burden and surgical maneuver. The drug could also boost TIL responses to tumor. These effects suggest that the drug be used as an immunomodulator for GI cancer patients.

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Section: Discussionmentioning

confidence: 85%

Perioperative cimetidine administration promotes peripheral blood lymphocytes and tumor infiltrating lymphocytes in patients with gastrointestinal cancer: Results of a randomized controlled clinical trial

Cai¹,

Bai²,

Yuan³

et al. 2004

WJG

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“…The analysis presented here compared this outcome for patients with converted laparoscopic resection with the corresponding outcome for patients with primary open resection. Based upon the premise that even if laparoscopic resection is advantageous in terms of lower immunosuppression [21,22,23], in the case of conversion the results should not be worse than those of primary open resection. If the results after conversion were less favorable than that of primary resection, the conversion group must be described as a high-risk population, which in turn would lead to the demand for an improvement of pre-operative selection of patients for laparoscopic resection with low risk of conversion.…”

Section: Influence Of Conversion On Long-term Resultsmentioning

confidence: 99%

Conversion from laparoscopic to open colonic cancer resection – Associated factors and their influence on long-term oncological outcome

Ptok

Kube

Schmidt

et al. 2009

European Journal of Surgical Oncology (EJSO)

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Methods: In a prospective study at 282 German hospitals demographic, tumor-and treatment-related data and disease-free survival were compared in the three groups. M A N U S C R I P T A C C E P T E D ARTICLE IN PRESS

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“…Another limitation is that only patients undergoing open colorectal surgery were included in this study. Whether patients undergoing minimally Lohsiriwat V. Opioid-spring effect of selective COX-2 inhibitor invasive surgery, who will have a less inflammatory and metabolic response to surgery compared with open surgery [42] , will be beneficial to the administration of selective COX-2 inhibitors are not investigated.…”

Section: Discussionmentioning

confidence: 99%

Opioid-sparing effect of selective cyclooxygenase-2 inhibitors on surgical outcomes after open colorectal surgery within an enhanced recovery after surgery protocol

Lohsiriwat

2016

Clinical Nutrition ESPEN

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Metabolic and Functional Results After Laparoscopic Colorectal Surgery

Cited by 124 publications

References 34 publications

Perioperative cimetidine administration promotes peripheral blood lymphocytes and tumor infiltrating lymphocytes in patients with gastrointestinal cancer: Results of a randomized controlled clinical trial

Perioperative cimetidine administration promotes peripheral blood lymphocytes and tumor infiltrating lymphocytes in patients with gastrointestinal cancer: Results of a randomized controlled clinical trial

Conversion from laparoscopic to open colonic cancer resection – Associated factors and their influence on long-term oncological outcome

Opioid-sparing effect of selective cyclooxygenase-2 inhibitors on surgical outcomes after open colorectal surgery within an enhanced recovery after surgery protocol

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