Metabolic and chemical studies on N-(4-chlorobenzyl)-N′-benzoylhydrazine

Küçükgüzel, Ş. Güniz; Küçükgüzel, İlkay; Ülgen, Mert

doi:10.1016/s0014-827x(00)00077-x

Cited by 11 publications

(3 citation statements)

References 9 publications

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“…The compounds benzohydrazide, 2‐hydroxybenzohydrazide, 4‐aminobenzohydrazide, 5‐phenyl‐4H‐1,2,4‐triazole‐3‐thiol, 1‐(4‐(5‐mercapto‐4‐phenyl‐4H‐1,2,4‐triazol‐3‐yl)phenyl)‐3‐phenylthiourea (I), O‐ethyl S‐(5‐phenyl‐4H‐1,2,4‐triazol‐3‐yl)carbonothioate (II), 4,5‐diphenyl‐4H‐1,2,4‐triazole‐3‐thiol (III), and 2‐(4‐amino‐5‐mercapto‐4H‐1,2,4‐triazol‐3‐yl)phenol (IV) were prepared according to recommended methods …”

Section: Methodsmentioning

confidence: 99%

Antimicrobial and antitumor activities of 1,2,4-triazoles/polypyrrole chitosan core shell nanoparticles

et al. 2017

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Combination of natural biodegradable polymer with a synthetic polymer offers excellent properties for the support in drug delivery system. For this purpose, biodegradable conductive nanoparticle polypyrrole based on chitosan (PPC) has been prepared via oxidative polymerization of pyrrole in presence of chitosan using FeCl 3 as oxidant in acidic medium and used as a carrier for 1,2,4-triazoles. The resultant nanoparticles were characterized by X-ray diffraction, Fourier transform infrared analysis, transmission electron microscopy, scanning electron microscopy, and thermal gravimetric analysis.The results indicate that spherical nanoparticle of average diameter 52 AE 8 nm was successfully prepared. The spherical particles were composed of dark sphere surrounded by grey shell. A circumferential dark ring is observed in the shell after loading 1,2,4triazoles into PPC nanoparticles. The loaded triazoles were released almost linearly against time in a sustained fashion into different pH media. The mechanism of triazoles release was determined using different kinetics equations. The antibacterial activities against the gram-negative and gram-positive bacteria were examined. Furthermore, the antitumor activity of PPC nanoparticles loaded 1,2,4-triazoles was also examined against Ehrlich ascites carcinoma cells and breast cancer cell line (MCF7). Polypyrrole chitosan loaded nanoparticles exhibited higher antitumor activity than 1,2,4-triazoles.KEYWORDS antibacterial activity, antitumor activity, drug delivery, kinetics of triazole released, polypyrrole chitosan nanoparticles

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Section: Methodsmentioning

confidence: 99%

Antimicrobial and antitumor activities of 1,2,4-triazoles/polypyrrole chitosan core shell nanoparticles

et al. 2017

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“…The actual MIC and IC 50 values of were 3.13 and 0.32 μg/mL. The compound 55 was also tested against M. avium (Kuçukguzel et al, 2000). The pyridylmethyleneamino derivative, compound 56 was showed activity against Gram negative, Gram positive Mtb H37Rv starins and some isonicotinoylhydrazones also showed a moderate activity against clinically isolated Mtb (6.25-50 μg/mL) which was INH resistant (Cocco et al, 2005).…”

Section: [R=h] 46[r=ch 3 ] 47 48[r=h] 49[r=ch 3 ]mentioning

confidence: 99%

Pharmacologically potentials of hydrazonone containing compounds: a promising scaffold

Asif

2014

International Journal of Advanced Chemistry

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“…[1][2][3][4] The immense importance of 4thiazolidinones based scaffolds in various medications including anti-tubercular, anti-cancer, anti-diabetic, anti-microbial, anti-inflammatory, anti-malarial, antiviral, aesthetic etc. has fascinated organic chemists for their synthesis via newer synthetic methods [5][6][7][8] .…”

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confidence: 99%

A Facile, Mechanochemical, Solvent-, and Catalyst-Free Synthesis of Functionalized 4-Thiazolidinones

Bhargava,

Wahan,

Chawla

et al. 2023

SynOpen

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A highly eco-friendly greener approach based on the mechanochemical method using mortar and pestle is explored for the preparation of a variety of functionalized 4-thiazolidinones. The developed methodology does not require the use of harmful or expensive reagents and organic solvents and requires very less reaction time with easy isolation. The explored greener approach for the synthesis of 4-thiazolidinones is an important in terms of their usefulness for their valuable pharmacological properties.

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Metabolic and chemical studies on N-(4-chlorobenzyl)-N′-benzoylhydrazine

Cited by 11 publications

References 9 publications

Antimicrobial and antitumor activities of 1,2,4-triazoles/polypyrrole chitosan core shell nanoparticles

Antimicrobial and antitumor activities of 1,2,4-triazoles/polypyrrole chitosan core shell nanoparticles

Pharmacologically potentials of hydrazonone containing compounds: a promising scaffold

A Facile, Mechanochemical, Solvent-, and Catalyst-Free Synthesis of Functionalized 4-Thiazolidinones

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