Metabolic and Cardiovascular Effects of Switching Thiazides to Amlodipine in Hypertensive Patients With and Without Type 2 Diabetes (the Diuretics and Diabetes Control Study)

Buscemi, Silvio; Buscemi, Carola; Borzì, Antonio Maria; Cosentino, Loretta; Rosafio, Giuseppe; Randazzo, Claudia; Colomba, Daniela; Raimondo, Domenico Di; Pluchinotta, Francesca R; Parrinello, Gaspare

doi:10.1089/met.2019.0099

Cited by 6 publications

(5 citation statements)

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“…[ 23 ] Endothelial dysfunction is an early marker for atherosclerosis in patients with malignancies and several studies demonstrated the effects of medications on improving this function. [ 24 25 ] Captopril is an ACE-I placed on the endothelium to affect angiotensin II and bradykinin activity and NO synthesis. [ 26 ] ACE-I had two activity including inhibition of Ang II formation and bradykinin breakdown and the effects of ACE-I on endothelial function is maybe due to these two mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Comparative evaluation of captopril, spironolactone, and carvedilol effect on endothelial function in breast cancer women undergoing chemotherapy

Tayebi,

Hashemi Jazi,

Teimouri-Jervekani

et al. 2023

Adv Biomed Res

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Background: Breast cancer is the most prevalent malignancy in females which needs chemotherapy treatment. Studies demonstrated that anti-cancer agents used for chemotherapy in cancer patient causes endothelium dysfunction. Several researches showed the efficacy of angiotensin-converting enzyme inhibitors, Carvedilol and Spironolactone on improving endothelial function. This study aimed to evaluate the effect of the combination of Spironolactone, Carvedilol, and Captopril on endothelial function in breast cancer patients. Materials and Methods: This study is a prospective Randomized Clinical Trial in breast cancer patients who underwent chemotherapy. Patients were divided into two groups who received the combination of Captopril, Spironolactone, and Carvedilol or standard regimen for 3 months during chemotherapy. Before and after intervention, ejection fraction (EF), E/A ratio and e’ and flow-mediated dilation (FMD) properties were calculated and then compared. Results: Fifty-eight patients with a mean age of 47.57 ± 9.46 years were evaluated. The mean FMD after the intervention is statistically different in case and controls (<0.001). E/A ratio and e’ are not statistically different between groups after intervention. The mean EF was not statistically different between the two groups after intervention. Conclusion: Prescribing combination of Carvedilol, Spironolactone, and Captopril in breast cancer patients undergoing chemotherapy can improve endothelial function and may have beneficial effects on diastolic function.

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Section: Discussionmentioning

confidence: 99%

Comparative evaluation of captopril, spironolactone, and carvedilol effect on endothelial function in breast cancer women undergoing chemotherapy

Tayebi,

Hashemi Jazi,

Teimouri-Jervekani

et al. 2023

Adv Biomed Res

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“…The most frequently studied CCBs are the dihydropyridines. In one study, amlodipine decreased sU levels by 1.1 mg/dL (from a mean AE SD of 6.1AE1.1 mg/dL to 5.0AE1.4 mg/dL) after 6 weeks of treatment, 12 and in another study, from 8.1 mg/dL to 7.3 mg/dL after 9 weeks (60 days) of treatment (P<.001). 13 Nitrendipine treatment for 6 weeks decreased sU levels from 7.6 to 5.8 mg/dL (vs placebo; P<.001).…”

Section: Lowering and Raising Serum Urate Levelsmentioning

confidence: 92%

Lowering and Raising Serum Urate Levels: Off-Label Effects of Commonly Used Medications

Leung

Yip

Pillinger

et al. 2022

Mayo Clinic Proceedings

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“…Результати останніх мета-аналізів довели, що гіперактивація РААС викликає розвиток ІР і зниження синтезу інсуліну, а фармакологічна блокада РААС покращує секрецію інсуліну та індекс HOMA-IR у пацієнтів з порушенням толерантності до глюкози або ЦД-2 . Наприклад, застосування БРА кандесартану 8 мг на добу протягом 3 місяців посилює першу фазу секреції інсуліну у пацієнтів з АГ та предіабетом, що зменшує постпрандіальну гіперглікемію і HbA1C [1, [40][41][42][43] . Прийом валсартану протягом 6 місяців покращує як першу, так і другу фазу секреції інсуліну, значно зменшує ІР у пацієнтів з АГ та порушенням толерантності до глюкози [34] .…”

Section: блокатори раасunclassified

“…В дослідженні CAPP частота розвитку ЦД-2 була нижча на 30% при застосуванні каптоприлу, в порівнянні з β-блокаторами і тіазидними діуретиками . В дослідженні SOLVD еналаприл знизив частоту розвитку ЦД-2 на 32% у пацієнтів без порушення толерантності до глюкози і на 42% у пацієнтів із порушенням толерантності до глюкози натщесерце протягом 3 років спостереження пацієнтів з асимптомною дисфункцією лівого шлуночка [43] . В дослідженні ANBP еналаприл знизив ризик виникнення ЦД-2 на 33% в порівнянні гідрохлортіазидом .…”

Section: блокатори раасunclassified

Insulin resistance and cardiovascular diseases: focus on common in pathogenesis and treatment.

Zhuravlyova,

Rohachova,

Sokolnikova

et al. 2023

Shidnoevr. z. vnutr. simejnoi med.

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The prevalence of cardiovascular disease and type 2 diabetes has increased dramatically worldwide over the past 30 years. These diseases have become a worldwide epidemic and the main cause of disability and premature death. The reasons for these negative trends are the wide distribution of improper nutrition, sedentary lifestyle, smoking, lack of sleep, which lead to the development of insulin resistance. Insulin resistance underlies the development of multiple metabolic disorders: hyperinsulinemia, hyperglycemia, proatherogenic dyslipidemia, and inflammation, which lead to cardiovascular disease and type 2 diabetes. With this in mind, scientists and medical professionals should focus on the development and implementation of effective methods for the prevention and treatment of insulin resistance. An important tasks are the implementation of a healthy lifestyle, namely proper nutrition and regular physical activity, the use of pharmacological drugs that improve cardiovascular risk factors. However, there remains a need for further research and improvement of these treatment methods, as well as the development of new methods of prevention and treatment of cardiovascular diseases and type 2 diabetes.

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Metabolic and Cardiovascular Effects of Switching Thiazides to Amlodipine in Hypertensive Patients With and Without Type 2 Diabetes (the Diuretics and Diabetes Control Study)

Cited by 6 publications

References 50 publications

Comparative evaluation of captopril, spironolactone, and carvedilol effect on endothelial function in breast cancer women undergoing chemotherapy

Comparative evaluation of captopril, spironolactone, and carvedilol effect on endothelial function in breast cancer women undergoing chemotherapy

Lowering and Raising Serum Urate Levels: Off-Label Effects of Commonly Used Medications

Insulin resistance and cardiovascular diseases: focus on common in pathogenesis and treatment.

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