Metabolic alterations in the peritumoral brain in cases of meningiomas: 1H-MRS study

Chernov, Mikhail; Nakaya, Kotaro; Kasuya, Hidetoshi; Kato, Koichi; Ono, Yuko; Yoshida, Shigetoshi; Nakamura, Ryoichi; Suzuki, Takashi; Muragakı, Yoshihiro; Iseki, Hiroshi; Kubo, Osami; Hori, Tomokatsu; Takakura, Kintomo

doi:10.1016/j.jns.2009.05.015

Cited by 12 publications

(4 citation statements)

References 30 publications

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“…Because creatine concentrations in the brain are considered stable, relative to other metabolites, metabolite-to-creatine estimated concentration ratios are used as evaluation methods in many studies. 5,[12][13][14] However, although this could not be evaluated statistically, our MRS results suggested that each age group (young, adult, and geriatric) in the study had higher creatine concentrations (as estimated via MRS) in the cerebellum than in the supratentorial region. This result is similar to those in previous reports 17,34,44 describing MRS results in children, adults, and the elderly.…”

Section: Discussionmentioning

confidence: 68%

“…8,9,11 Metabolite concentrations can be estimated through measurement of MRS signal intensity where absolute quantitation cannot be performed. In some MRS studies, [12][13][14] metabolite ratios (eg, N-acetyl asparate-to-creatine, choline-to-creatine, and N-acetyl asparate-to-choline ratios) have been used to investigate metabolic changes in human brain tissue under various conditions. For example, the N-acetyl aspartate-to-choline ratio is considered an indicator of neuronal activity because N-acetyl aspartate is specific to neurons and choline is regarded as a marker of cellular density.…”

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confidence: 99%

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Regional variations and age-related changes detected with magnetic resonance spectroscopy in the brain of healthy dogs

Ono¹,

Kitagawa²,

Ito³

et al. 2014

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Section: Discussionmentioning

confidence: 68%

mentioning

confidence: 99%

Regional variations and age-related changes detected with magnetic resonance spectroscopy in the brain of healthy dogs

Ono¹,

Kitagawa²,

Ito³

et al. 2014

ajvr

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“…In the brain tumor state, the peak NAA was significantly reduced, and the degree of reduction was closely related to the degree of neuronal destruction. However, in fact, low NAA peaks are seen in 1H-MRS in patients with metastases and meningiomas, probably due to tumor marginal voxel effect or tumor invasion of normal brain tissue [ 18 ]. In addition, the Cho peak was distributed at 3.22 × 10 −6 , which is an important indicator of glial proliferation, cell metabolism, and myelin formation.…”

Section: Discussionmentioning

confidence: 99%

Hydrogen Proton Magnetic Resonance Spectroscopy (MRS) in Differential Diagnosis of Intracranial Tumors: A Systematic Review

Wang

Chen

Dai

2022

Contrast Media & Molecular Imaging

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Meningioma, glioma, and metastases are the most common intracranial tumors in clinical practice. In order to improve the prognosis of patients, timely diagnosis and early treatment are crucial. Hydrogen proton magnetic resonance spectroscopy (1H-MRS) imaging can noninvasively display the biochemical information of tissues in vivo and has been applied to identify and diagnose intracranial tumors. We want to comprehensively evaluate 1H-MRS identify and diagnose intracranial tumors by meta-analysis. Some databases such as PubMed and Cochrane Library were used to systematically search articles that were about identifying and diagnosing intracranial tumors with 1H-MRS. Then, weighted mean difference (WMD) was used as an effect size to conduct meta-analysis. There are altogether nine articles, including 533 patients. Results of meta-analysis: The Cho/Cr and Cho/NAA ratios in the LGG group were significantly lower than those in the HGG group (WMD = −0.69, 95% CI (−0.92, −0.45), P < 0.001 , WMD = −0.76, 95% CI (−1.03, −0.48), P < 0.001 ). The Cho/Cr ratio of tumor and peritumor in the HGG group was significantly different from that in the metastasis group (0.68, 95% CI (−1.27, 2.62), P < 0.001 , WMD = 0.94, 95% CI (0.41, 1.47), P < 0.001 ). There was no significant difference in the tumor and peritumor NAA/Cr ratio between the HGG group and metastasis group (WMD = −0.64, 95% CI (−1.63, 0.34), P = 0.31 , WMD = −0.22, 95% CI (−0.59, 0.15), P = 0.24 ). 1H-MRS can provide metabolic information of different intracranial tumors and can effectively diagnose and differentiate glioma and metastasis. 1H-MRS can also provide a reliable basis for the classification of glioma, and has certain clinical application value.

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“…In our experiences, the MRS data can provide unique information that when combined with BOLD and DTI has implications for defining tumor type and grade, directing biopsy or surgical resection. To review the findings of this study and relative literatures (1,3,4,(6)(7)(8)(15)(16)(17)(18)19,28,31,38), typical changes of various metabolites among different types of lesions were summarized in Table II. The value of proton MRS for predicting tumor malignancy which was known as an important branch of clinical application has been reported in several prior clinical studies (5,(12)(13)(14)19,22,27). Similar to our results, the ratio of Cho/Cr and Cho/NAA in high grade gliomas were found significantly higher than in low grade gliomas, and lipid peak was usually defined in high grade gliomas, which was strongly associated with the presence and amount of necrosis in glioma.…”

Section: Shang H Et Al: Preoperative Assessment Of Glioma Using F-mrimentioning

confidence: 99%

Preoperative assessment using multimodal functional magnetic resonance imaging techniques in patients with brain gliomas

Shang

Zhao²,

Zhang³

2011

Turkish Neurosurgery

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AIm:To evaluate the value of magnetic resonance spectroscopy (MRS), blood oxygen level-dependent imaging (BOLD) and diffusion tensor imaging (DTI) for preoperative assessment in patients with brain gliomas. mATeRIAL and meTHods: Twenty-three consecutive glioma patients underwent MRS, BOLD and DTI before operation. The characteristics of images were analysed according to histopathological results. ResuLTs:There is significant elevation of the choline (Cho) /creatine (Cr) ratio, Cho peak and depression of the N-acetylaspartate (NAA) peak in gliomas. Elevation of the Cho/Cr, Cho/NAA ratio and the presence of a lipids peak, were consistent with high-grade malignancy. A motor activation scan was achieved by using a motor task paradigm in 20 patients. Deformation and displacement of the motor activations was found in 5 cases. The margin of tumor and peritumoural white matter tracts were identified using apparent diffusion coefficient (ADC) and fractional anisotropy (FA) maps. Three patterns of white matter tracts alteration were identified: displacement, infiltration, and disruption. In all 23 patients, the tumors were completely resected in 6 patients, subtotal resected in 8 patients, partial resected in 9 patients. No secondary neurological deficit was occurred in all patients after operation. CoNCLusIoN:The combination of MRS, BOLD, and DTI techniques allows appropriate presurgical planning of brain gliomas.KeywoRds: Glioma, Operation, Functional magnetic resonance imaging ÖZ AmAÇ: Beyin gliomlu hastalarda preoperatif değerlendirme için manyetik rezonans spektroskopisi (MRS), kan oksijen seviyesine bağımlı görüntüleme (BOLD) ve difüzyon tensor görüntülemenin (DTI) önemini değerlendirmek. yÖNTem ve GeReÇLeR: Arka arkaya 23 gliom hastasında ameliyat öncesinde MRS, BOLD ve DTI yapıldı. Görüntülerin özellikleri histopatolojik sonuçlara göre değerlendirildi.BuLGuLAR: Gliomlarda kolin (Cho) /kreatin (Cr) oranı ve Cho tepe değerinde önemli artış varken N-asetilaspartat (NAA) tepe değerinde azalma görülür. Cho/Cr ve Cho/NAA oranı artışı ve bir lipid tepe değerinin varlığı yüksek dereceli malignansi ile tutarlıydı. Bir motor görev paradigması kullanılarak 20 hastada bir motor aktivasyon taraması yapıldı. Beş vakada motor aktivasyonlarda deformasyon ve displasman bulundu. Peritümöral beyaz madde kanalları ve tümör kenarı görünür difüzyon katsayısı (ADC) ve fraksiyonel anisotropi (FA) haritaları kullanılarak tanımlandı. Üç beyaz madde kanalı değişme paterni tanımlandı: displasman, infiltrasyon ve bozulma. Bu 23 hasta içinde 6 hastada tamamen tümör rezeksiyonu yapıldı, 8 hastada subtotal rezeksiyon yapıldı ve 9 hastada kısmi rezeksiyon yapıldı. Ameliyattan sonra hiçbir hastada ikincil nörolojik defisit görülmedi. soNuÇ: MRS, BOLD ve DTI tekniklerinin kombinasyonu beyin gliomlarında cerrahi öncesi uygun planlamayı mümkün kılar.

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Metabolic alterations in the peritumoral brain in cases of meningiomas: 1H-MRS study

Cited by 12 publications

References 30 publications

Regional variations and age-related changes detected with magnetic resonance spectroscopy in the brain of healthy dogs

Regional variations and age-related changes detected with magnetic resonance spectroscopy in the brain of healthy dogs

Hydrogen Proton Magnetic Resonance Spectroscopy (MRS) in Differential Diagnosis of Intracranial Tumors: A Systematic Review

Preoperative assessment using multimodal functional magnetic resonance imaging techniques in patients with brain gliomas

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