Metabolic alterations in carcinoma ex pleomorphic adenoma development of lacrimal glands

MicroRNA copy number alterations in the malignant transformation of pleomorphic adenoma to carcinoma ex pleomorphic adenoma

“…It is essential to emphasize that a significant number of CNA in miRNA genes identified in this study are linked to the metabolic changes that occur in neoplastic cells as they adapt to the tumor microenvironment, thereby facilitating tumor progression 96 . Metabolic reprogramming, a well‐recognized hallmark of cancer, 97 has been extensively explored in these tumors, and our results are consistent with previous studies from our group 8,9,98,99 . The Warburg effect, also recognized as aerobic glycolysis, is a distinctive feature of cancer metabolism.…”

“…96 Metabolic reprogramming, a well-recognized hallmark of cancer, 97 has been extensively explored in these tumors, and our results are consistent with previous studies from our group. 8,9,98,99 The Warburg effect, also recognized as aerobic glycolysis, is a distinctive feature of cancer metabolism. Several studies suggest that miRNAs may play a role in governing the Warburg effect by influencing oncogenes or tumor suppressors like cMyc, HIF-1, and P53.…”

Malignant phenotype acquisition in pleomorphic adenoma: An exclusive proteins analysis

“…Our recent systematic review based on the discovery proteomics provided evidence of proteins related to metabolic events in PA (de Lima-Souza,Scarini, Lavareze, Emerick, dos Santos, et al, 2022). Although some studies already have investigated metabolic shifts in the PA and CXPA (deLima-Souza, Rodrigues, et al, 2022;Díaz et al, 2019; do Prado et al, 2011;Scarini et al, 2020), the results of this work highlighted a novel panel of proteins related to metabolic changes in the PA-CXPA transition.…”

Interdisziplinäre Therapie der Erkrankungen der Orbita

“…In diesem Bereich wird u. a. das PLAG1 Oncoprotein kodiert [342]. Tumorzellen von pleomorphen Adenomen exprimieren HIF-1α (Hypoxie-induzierter-Faktor), einem Transkriptions-und Hypoxie induzierbaren Faktor, der u. a. Signalwege zur Sauerstoffversorgung der Zellen und die Expres sion von Vascular endothelial growth Factor exprimiert, was als Unterscheidungsmerkmal zu adenoidzystischen Karzinomen und zum Karzinom ex pleomorphen Adenom herangezogen werden kann [343,344]. Sonographisch zeigt sich eine gut abgrenzbare echoarme Raumforderung, die häufig polyzyklisch begrenzt ist, mit dorsaler Schallverstärkung.…”